Search Results - "Sibanda, B"

Leveraging nurse practitioner capacities to achieve global health for all: COVID‐19 and beyond by Rosa, W.E., Fitzgerald, M., Davis, S., Farley, J.E., Khanyola, J., Kwong, J., Moreland, P.J., Rogers, M., Sibanda, B., Turale, S.

“…Aim To argue that nurse practitioners have been under‐utilized generally in the current global health environment, creating barriers to achieving universal…”
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Achieving selectivity in space and time with DNA double-strand-break response and repair: molecular stages and scaffolds come with strings attached by Liang, S., Esswein, S. R., Ochi, T., Wu, Q., Ascher, D. B., Chirgadze, D., Sibanda, B. L., Blundell, T. L.

“…When double-strand breaks (DSBs) in DNA remain unrepaired, catastrophic loss of genes occurs, leading to translocations, mutations and carcinogenesis. If a…”
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Crystal structure of an Xrcc4-DNA ligase IV complex by Pellegrini, Luca, Sibanda, Bancinyane L, Critchlow, Susan E, Begun, Jake, Pei, Xue Y, Jackson, Stephen P, Blundell, Tom L

“…A complex of two proteins, Xrcc4 and DNA ligase IV, plays a fundamental role in DNA non-homologous end joining (NHEJ), a cellular function required for…”
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Knowledge-based prediction of protein structures and the design of novel molecules by Blundell, T. L, Sibanda, B. L, Sternberg, M. J. E, Thornton, J. M

“…Prediction of the tertiary structures of proteins may be carried out using a knowledge-based approach. This depends on identification of analogies in secondary…”
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Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering by Sibanda, B L, Blundell, T L, Thornton, J M

“…A systematic classification of beta-hairpin structures which takes into account the polypeptide chain length and hydrogen bonding between the two antiparallel…”
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β -Hairpin families in globular proteins by Sibanda, B. L, Thornton, J. M

“…Beta-hairpins, one of the simplest supersecondary structures, are widespread in globular proteins, and have often been suggested as possible sites for…”
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Community-based TB testing as an essential part of TB recovery plans in the COVID-19 era by Zokufa, N., Lebelo, K., Hacking, D., Tabo, L., Runeyi, P., Malabi, N., Sibanda, S. B., Cassidy, T., Makanda, G., Norman, B., Khuzani, S., Furin, J., Jonker, C., Nkasana, B., Scott, V., Pfaff, C.

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Protein-protein interactions in receptor activation and intracellular signalling by Blundell, T L, Burke, D F, Chirgadze, D, Dhanaraj, V, Hyvönen, M, Innis, C A, Parisini, E, Pellegrini, L, Sayed, M, Sibanda, B L

“…We review here signalling complexes that we have defined using X-ray analysis in our laboratory. They include growth factors and their receptors: nerve growth…”
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Whose language is it anyway? Students’ sense of belonging and role of English for Higher Education in the multilingual, South African context by Joubert, M., Sibanda, B.

“…The current decolonial commitments in Higher Education necessitate a need to deepen our understanding of the relationship between English as a Medium of…”
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Prevalence and Risk Factors of Emergency Department Presentations with Methamphetamine Intoxication or Dependence: A Systematic Review and Meta-analysis by Sibanda, Njabulo Churchill, Kornhaber, Rachel, Hunt, Glenn E., Morley, Kirsten, Cleary, Michelle

“…Background: Methamphetamine intoxication presentations to emergency departments (EDs) including trauma centres, general EDs and psychiatric emergency services…”
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Structure of an Xrcc4–DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode by Doré, Andrew S., Furnham, Nicholas, Davies, Owen R., Sibanda, Bancinyane L., Chirgadze, Dimitri Y., Jackson, Stephen P., Pellegrini, Luca, Blundell, Tom L.

“…DNA ligase IV catalyses the final ligation step in the non-homologous end-joining (NHEJ) DNA repair pathway and requires interaction of the ligase with the…”
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X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins by Dhanaraj, V, Dealwis, C. G, Frazao, C, Badasso, M, Sibanda, B. L, Tickle, I. J, Cooper, J. B, Driessen, H. P. C, Newman, M, Aguilar, C, Wood, S. P, Blundell, T. L, Hobart, P. M, Geoghegan, K. F, Ammirati, M. J, Danley, D. E, O'Connor, B. A, Hoover, D. J

“…X-ray analyses have defined the three-dimensional structures of crystals of mouse and human renins complexed with peptide inhibitors at resolutions of 1.9 and…”
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Causes of loss to follow-up from drug-resistant TB treatment in Khayelitsha, South Africa by Memani, B., Beko, B., Dumile, N., Mohr-Holland, E., Daniels, J., Sibanda, B., Damse, Z., Scott, V., von der Heyden, E., Pfaff, C., Reuter, A., Furin, J.

“…Patients initiated on drug-resistant TB(DR-TB) treatment in 2019 in Khayelitsha, South Africa, with a loss to follow-up outcome were evaluated to better…”
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Accommodating sequence changes in beta-hairpins in proteins by Sibanda, B L, Thornton, J M

“…A systematic study of homologous beta-hairpins in proteins of known structure reveals how insertions and deletions (herein known as indels) in the sequence are…”
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Conformation of beta hairpins in protein structures: classification and diversity in homologous structures by Sibanda, B L, Thornton, J M

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Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self-processing by Albert, Armando, Dhanaraj, Venugopal, Genschel, Ulrich, Khan, Ghalib, Ramjee, Manoj K, Pulido, Rosaline, Sibanda, B. Lynn, Delft, Frank von, Witty, Michael, Blundell, Tom L, Smith, Alison G, Abell, Chris

“…The structure of L-aspartate-alpha-decarboxylase from E. coli has been determined at 2.2 A resolution. The enzyme is a tetramer with pseudofour-fold rotational…”
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High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes by Foundling, S. I, Cooper, J, Watson, F. E, Cleasby, A, Pearl, L. H, Sibanda, B. L, Hemmings, A, Wood, S. P, Blundell, T. L, Valler, M. J, Norey, C. G, Kay, J, Boger, J, Dunn, B. M, Leckie, B. J, Jone, D. M, Atrash, B, Hallett, A, Szelke, M

“…Inhibitors of the conversion of angiotensinogen to the vasoconstrictor angiotensin II have considerable value as antihypertensive agents. For example,…”
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Analysis, design and modification of loop regions in proteins by Thornton, J M, Sibanda, B L, Edwards, M S, Barlow, D J

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Computer graphics modelling of human renin: Specificity, catalytic activity and intron-exon junctions by Sibanda, Bancinyane L., Blundell, Tom, Hobart, Peter M., Fogliano, M., Bindra, Jasjit S., Dominy, Beryl W., Chirgwin, John M.

“…A model has been constructed using computer graphics for human renin based on the sequence derived from that of the gene and the 3-dimensional structure…”
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Differential effects of drugs upon hematopoiesis can be assessed in long-term bone marrow cultures established on nylon screens by Naughton, B A, Sibanda, B, Azar, L, San Roman, J

“…Hematotoxicity is associated with exposure to chemotherapeutic drugs and numerous other agents. Most measurements of the hematopoietic effects of prospective…”
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