Search Results - "Sibaev, A."

G protein‐coupled estrogen receptor and estrogen receptor ligands regulate colonic motility and visceral pain by Zielińska, M., Fichna, J., Bashashati, M., Habibi, S., Sibaev, A., Timmermans, J.‐P., Storr, M.

“…Background Diarrhea‐predominant irritable bowel syndrome (IBS‐D) is a functional gastrointestinal (GI) disorder, which occurs more frequently in women than…”
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Novel orally available salvinorin A analog PR-38 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome by Sałaga, M, Polepally, P R, Sobczak, M, Grzywacz, D, Kamysz, W, Sibaev, A, Storr, M, Do Rego, J C, Zjawiony, J K, Fichna, J

“…The opioid and cannabinoid systems play a crucial role in multiple physiological processes in the central nervous system and in the periphery. Selective opioid…”
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The cannabinoid‐1 receptor inverse agonist taranabant reduces abdominal pain and increases intestinal transit in mice by Fichna, J., Sibaev, A., Sałaga, M., Sobczak, M., Storr, M.

“…Background Constipation‐predominant irritable bowel syndrome (IBS‐C) is a common functional gastrointestinal (GI) disorder with abdominal pain and decreased…”
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Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis by MASSA, F, SIBAEV, A, MARSICANO, G, BLAUDZUN, H, STORR, M, LUTZ, B

“…In the human colon, vanilloid receptor TRPV1 is overexpressed both in afferent nerve terminals and in epithelial cells during inflammation. In the past years,…”
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Targeting fatty acid amide hydrolase and transient receptor potential vanilloid‐1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N‐arachidonoyl‐serotonin (AA‐5‐HT) by Bashashati, M., Fichna, J., Piscitelli, F., Capasso, R., Izzo, A. A., Sibaev, A., Timmermans, J.‐P., Cenac, N., Vergnolle, N., Di Marzo, V., Storr, M.

“…Background Endocannabinoid anandamide (AEA) inhibits intestinal motility and visceral pain, but it may also be proalgesic through transient receptor potential…”
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FABP4 blocker attenuates colonic hypomotility and modulates white adipose tissue‐derived hormone levels in mouse models mimicking constipation‐predominant IBS by Mosińska, P., Jacenik, D., Sałaga, M., Wasilewski, A., Cygankiewicz, A., Sibaev, A., Mokrowiecka, A., Małecka‐Panas, E., Pintelon, I., Storr, M., Timmermans, J. P., Krajewska, W. M., Fichna, J.

“…Background The role of fatty acid binding protein 4 (FABP4) in lower gastrointestinal (GI) motility is unknown. We aimed to verify the effect of inhibition of…”
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Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon by Storr, M, Sibaev, A, Marsicano, G, Lutz, B, Schusdziarra, V, Timmermans, J-P, Allescher, H D

“…The effects of cannabinoid receptor agonists and antagonists on smooth muscle resting membrane potentials and on membrane potentials following electrical…”
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Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex by Yuece, B., Sibaev, A., Broedl, U. C., Marsicano, G., Göke, B., Lutz, B., Allescher, H. D., Storr, M.

“…Cannabinoid‐1 (CB1) receptor activation affects gastrointestinal propulsion in vivo. It was our aim to further characterize the involved myenteric mechanisms…”
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Cannabinoid 1 receptors modulate intestinal sensory and motor function in rat by Yüce, B., Kemmer, M., Qian, G., Müller, M., Sibaev, A., Li, Y., Kreis, M. E., Storr, M.

“…Background  Cannabinoid receptors are involved in visceral pain perception and control of intestinal motility in vivo. The underlying mechanisms are not well…”
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Intestinal Afferent Nerve Sensitivity is Increased During the Initial Development of Postoperative Ileus in Mice by Mueller, M. H., Karpitschka, M., Xue, B., Kasparek, M. S., Sibaev, A., Glatzle, J., Kreis, M. E.

“…Introduction Neuronal reflex inhibition of gastrointestinal motility is a key mechanism in the development of postoperative ileus (POI). The aim of our study…”
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Mast cells and the cyclooxygenase pathway mediate colonic afferent nerve sensitization in a murine colitis model by Xue, B, Müller, M.H, Li, J, Pesch, T, Kasparek, M.S, Sibaev, A, Hausmann, M, Rogler, G, Kreis, M.E

“…Abstract Introduction Intestinal inflammation alters colonic afferent nerve sensitivity which may contribute to patients' perception of abdominal discomfort…”
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Afferent nerve sensitivity is decreased by an iNOS‐dependent mechanism during indomethacin‐induced inflammation in the murine jejunum in vitro by Xue, B., Hausmann, M., Müller, M. H., Pesch, T., Karpitschka, M., Kasparek, M. S., Hu, W. C., Sibaev, A., Rogler, G., Kreis, M. E.

“…Evidence exists that visceral afferent sensitivity is subject to regulatory mechanisms. We hypothesized that afferent sensitivity is decreased in the small…”
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CB1 and TRPV1 receptors mediate protective effects on colonic electrophysiological properties in mice by SIBAEV, A, MASSA, F, YUCE, B, MARSICANO, G, LEHR, H. A, LUTZ, B, GÖKE, B, ALLESCHER, H. D, STORR, M

“…CB1 and TRPV1 receptors modulate enteric neurotransmission and colonic inflammation. This study investigates early electrophysiological changes in distal colon…”
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Assessment of the efficacy and safety of the phytopharmacon STW 5 versus metoclopramide in functional dyspepsia--a retrolective cohort study by Raedsch, R, Hanisch, J, Bock, P, Sibaev, A, Vinson, B, Gundermann, K-J

“…The objective of this study was to assess the efficacy and safety of the phytopharmacon STW 5 versus metoclopramide in functional dyspepsia. A retrolective,…”
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STW 5 (Iberogast ®) and its individual herbal components modulate intestinal electrophysiology of mice by Sibaev, A., Yuece, B., Kelber, O., Weiser, D., Schirra, J., Göke, B., Allescher, H.D., Storr, M.

“…STW 5 (Iberogast ®), a phytomedicine consisting of a fixed combination of nine individual plant extracts, is widely used in the treatment of dyspepsia and…”
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Melatonin reduces non-adrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro by Storr, M., Koppitz, P., Sibaev, A., Saur, D., Kurjak, M., Franck, H., Schusdziarra, V., Allescher, H.-D.

“…The aim of the present study was to investigate the effects of melatonin on non‐adrenergic, non‐cholinergic (NANC) relaxant neurotransmission in the…”
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A novel herbal preparation desensitizes mesenteric afferents to bradykinin in the rat small intestine by Mueller, M. H., Gong, Q., Kelber, O., Kasparek, M. S., Sibaev, A., Mansmann, U., Yuce, B., Li, Y. Y., Storr, M., Kreis, M. E.

“…Herbal preparations are evolving as promising agents for the treatment of functional gastrointestinal disorders which are considered to be secondary to…”
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Herbal extracts modulate the amplitude and frequency of slow waves in circular smooth muscle of mouse small intestine by Storr, M, Sibaev, A, Weiser, D, Kelber, O, Schirra, J, Goke, B, Allescher, H D

“…Herbal preparations like STW 5 (Iberogast) are widely used drugs in the treatment of dyspepsia and motility-related disorders of the gastrointestinal tract…”
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The endogenous cannabinoid system protects against colonic inflammation by Massa, Federico, Marsicano, Giovanni, Hermann, Heike, Cannich, Astrid, Monory, Krisztina, Cravatt, Benjamin F, Ferri, Gian-Luca, Sibaev, Andrei, Storr, Martin, Lutz, Beat

“…Excessive inflammatory responses can emerge as a potential danger for organisms' health. Physiological balance between pro- and anti-inflammatory processes…”
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447 Micturition is controlled by neuronal cannabinoid receptor type 1 – a urodynamic evaluation of a CB1 knockout mouse model by Fullhase, C, Campeau, L, Sibaev, A, Storr, M, Gratzke, C, Stief, C, Hedlund, P, Andersson, K.E

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