Search Results - "Siano, Álvaro"

Inhibition of Human Cholinesterases and in vitro β‐Amyloid Aggregation by Rationally Designed Peptides by Sanchis, Ivan, Spinelli, Roque, Dias, José, Brazzolotto, Xavier, Rietmann, Álvaro, Aimaretti, Florencia, Siano, Álvaro S.

“…The multifactorial nature of Alzheimer's disease (AD) is now widely recognized, which has increased the interest in compounds that can address more than one…”
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Toxicity Evaluation of Anti‐cholinesterasic Amphibian Extracts by MTT and an Optimized Artemia salina Test by Spinelli, Roque, Rietmann, Álvaro, Sanchis, Iván, Goicoechea, Héctor, Siano, Álvaro

“…The amphibian skin is an important source of bioactive compounds. Recently, our workgroup reported the bioactivity of new extracts from the Hylidae,…”
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Functional Autoreactive Anti-β2 Adrenergic Antibodies May Contribute to Insulin Resistance Profile in Patients with Chronic Chagas Disease by Rodeles, Luz María, Vicco, Miguel Hernán, Siano, Álvaro, Fuchs, Leonardo Andrés, Peverengo, Luz María, Sanchez Puch, Silvia, Cymeryng, Cora Beatriz, Marcipar, Iván Sergio, Arias, Pablo

“…Potential activation of β2 adrenergic receptors (β2AR) by specific autoreactive antibodies (Abs) that arise during the host reaction to , could contribute to…”
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Disruption of Saccharomyces cerevisiae by Plantaricin 149 and investigation of its mechanism of action with biomembrane model systems by Lopes, José Luiz S., Nobre, Thatyane M., Siano, Álvaro, Humpola, Verónica, Bossolan, Nelma R.S., Zaniquelli, Maria. E.D., Tonarelli, Georgina, Beltramini, Leila M.

“…The action of a synthetic antimicrobial peptide analog of Plantaricin 149 (Pln149a) against Saccharomyces cerevisiae and its interaction with biomembrane model…”
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Rational design and synthesis of modified natural peptides from Boana pulchella (anura) as acetylcholinesterase inhibitors and antioxidants by Sanchis, Ivan, Spinelli, Roque, Aschemacher, Nicolas, Siano, Alvaro Sebastían

“…The use of acetylcholinesterase (AChE) inhibitors, antioxidants or multitarget compounds are among the main strategies against Alzheimer’s disease (AD)…”
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Development of an electrochemical sensor using carbon nanotubes and hydrophobic natural deep eutectic solvents for the detection of α-glucosidase activity in extracts of autochthonous medicinal plants by Aschemacher, Nicolás A., Teglia, Carla M., Siano, Álvaro S., Gutierrez, Fabiana A., Goicoechea, Héctor C.

“…The present work describes for the first time the use of a hydrophobic natural deep eutectic solvent (H-NADES) as a dispersant for carboxylated nanotubes for…”
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Highly sensitive and selective electrochemical sensor for simultaneous determination of gallic acid, theophylline and caffeine using poly(l-proline) decorated carbon nanotubes in biological and food samples by Aschemacher, Nicolás A., Gegenschatz, Sofía A., Teglia, Carla M., Siano, Álvaro S., Gutierrez, Fabiana A., Goicoechea, Héctor C.

“…In this work, a novel, simple and reproducible poly(l-proline)/functionalized multi-walled carbon nanotube composite on glassy carbon electrode…”
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Natural multi-target modulators of pathological pathways in Alzheimer's disease isolated from the Rhinella arenarum skin by Spinelli, Roque, Rietmann, Álvaro, Sanchis, Ivan, Siano, Álvaro Sebastián

“…The skin of anuran amphibians is a rich source of compounds with great medicinal potential. Alzheimer's disease (AD) is a complex disease associated with…”
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Removal of enrofloxacin using Eichhornia crassipes in microcosm wetlands by Teglia, Carla M., Hadad, Hernán R., Uberti-Manassero, Nora, Siano, Álvaro S., Repetti, María R., Goicoechea, Héctor C., Culzoni, María J., Maine, María A.

“…The global consumption of antibiotics leads to their possible occurrence in the environment. In this context, nature-based solutions (NBS) can be used to…”
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Development of low-cost cage-like particles to formulate veterinary vaccines by Lupi, Giuliana A., Santiago Valtierra, Florencia X., Cabrera, Gabriel, Spinelli, Roque, Siano, Álvaro S., González, Verónica, Osuna, Antonio, Oresti, Gerardo M., Marcipar, Iván

“…Low-cost adjuvants are urgently needed for the development of veterinary vaccines able to trigger strong immune responses. In this work, we describe a method…”
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Amphibian skin extracts as source of bioactive multi-target agents against different pathways of Alzheimer's disease by Spinelli, Roque, Aimaretti, Florencia María, López, Javier Alejandro, Siano, Alvaro Sebastián

“…Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin…”
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Acetylcholinesterase inhibitory activity of a naturally occurring peptide isolated from Boana pulchella (Anura: Hylidae) and its analogs by Sanchis, Ivan, Spinelli, Roque, Aschemacher, Nicolas, Humpola, Ma. Veronica, Siano, Alvaro

“…Alzheimer’s disease (AD), the most common form of dementia, is a growing problem worldwide, with 10 million incident cases registered every year. The complex…”
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Cytotoxic and antiproliferative activities of amphibian (anuran) skin extracts on human acute monocytic leukemia cells by Spinelli, Roque, Barrero Guevara, Laura Andrea, López, Javier Alejandro, Camargo, Carolina Muñoz, Groot de Restrepo, Helena, Siano, Alvaro Sebastián

“…The use of preparations derived from frog skins for curative purposes antedates research history and is perpetuated in current medicine. The skins of anuran's…”
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Trichogin GA IV Alignment and Oligomerization in Phospholipid Bilayers by Salnikov, Evgeniy S., De Zotti, Marta, Bobone, Sara, Mazzuca, Claudia, Raya, Jesus, Siano, Alvaro S., Peggion, Cristina, Toniolo, Claudio, Stella, Lorenzo, Bechinger, Burkhard

“…Trichogin GA IV is a short peptaibol with antimicrobial activity. This uncharged, but amphipathic, sequence is aligned at the membrane interface and undergoes…”
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Natural Multi‐Target Inhibitors of Cholinesterases and Monoamine Oxidase Enzymes with Antioxidant Potential from Skin Extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae) by Spinelli, Roque, Sanchis, Ivan, Aimaretti, Florencia M., Attademo, Andres M., Portela, Madelon, Humpola, Maria V., Tonarelli, Georgina G., Siano, Alvaro S.

“…Alzheimer's disease (AD) is the most common cause of dementia, characterized by loss of selective neuronal and normal brain functions. Every year, ten million…”
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A Peptide-Based Trap for Metal Ions Studied by Electron Paramagnetic Resonance by Syryamina, Victoria N., Siano, Alvaro S., Formaggio, Fernando, De Zotti, Marta

“…Peptide-based materials provide a versatile platform for sensing and ion sequestration since peptides are endowed with stimuli-responsive properties. The…”
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Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides by Siano, Alvaro, Humpola, Maria Veronica, de Oliveira, Eliandre, Albericio, Fernando, Simonetta, Arturo C, Lajmanovich, Rafael, Tonarelli, Georgina G

“…Amphibians´ skin produces a diverse array of antimicrobial peptides that play a crucial role as the first line of defense against microbial invasion. Despite…”
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Front Cover: Inhibition of Human Cholinesterases and in vitro β‐Amyloid Aggregation by Rationally Designed Peptides (ChemMedChem 12/2023) by Sanchis, Ivan, Spinelli, Roque, Dias, José, Brazzolotto, Xavier, Rietmann, Álvaro, Aimaretti, Florencia, Siano, Álvaro S.

“…The Front Cover shows the aromatic interactions between the indole side‐chain of peptide W3 and the peripheral aromatic site of acetylcholinesterase. W3…”
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Rational Design of Antiangiogenic Helical Oligopeptides Targeting the Vascular Endothelial Growth Factor Receptors by Zanella, Simone, Bocchinfuso, Gianfranco, De Zotti, Marta, Arosio, Daniela, Marino, Franca, Raniolo, Stefano, Pignataro, Luca, Sacco, Giovanni, Palleschi, Antonio, Siano, Alvaro S, Piarulli, Umberto, Belvisi, Laura, Formaggio, Fernando, Gennari, Cesare, Stella, Lorenzo

“…Tumor angiogenesis, essential for cancer development, is regulated mainly by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs), which…”
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D- and N-Methyl Amino Acids for Modulating the Therapeutic Properties of Antimicrobial Peptides and Lipopeptides by Humpola, Maria Veronica, Spinelli, Roque, Erben, Melina, Perdomo, Virginia, Tonarelli, Georgina Guadalupe, Albericio, Fernando, Siano, Alvaro Sebastian

“…Here we designed and synthesized analogs of two antimicrobial peptides, namely C10:0-A2, a lipopeptide, and TA4, a cationic α-helical amphipathic peptide, and…”
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