Search Results - "Sia, Sin Fun"

Phosphoantigen-Expanded Human γδ T Cells Display Potent Cytotoxicity against Monocyte-Derived Macrophages Infected with Human and Avian Influenza Viruses by Qin, Gang, Mao, Huawei, Zheng, Jian, Sia, Sin Fun, Liu, Yinping, Chan, Ping-Lung, Lam, Kwok-Tai, Peiris, J. S. Malik, Lau, Yu-Lung, Tu, Wenwei

“…BackgroundInfluenza virus is a cause of substantial annual morbidity and mortality worldwide. The potential emergence of a new pandemic strain (eg, avian…”
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Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells by Law, Helen K.W., Cheung, Chung Yan, Ng, Hoi Yee, Sia, Sin Fun, Chan, Yuk On, Luk, Winsie, Nicholls, John M., Peiris, J. S. Malik, Lau, Yu Lung

“…Lymphopenia and increasing viral load in the first 10 days of severe acute respiratory syndrome (SARS) suggested immune evasion by SARS-coronavirus (CoV). In…”
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Influenza Virus Directly Infects Human Natural Killer Cells and Induces Cell Apoptosis by Mao, Huawei, Tu, Wenwei, Qin, Gang, Law, Helen Ka Wai, Sia, Sin Fun, Chan, Ping-Lung, Liu, Yinping, Lam, Kwok-Tai, Zheng, Jian, Peiris, Malik, Lau, Yu-Lung

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Cytokine Responses in Severe Acute Respiratory Syndrome Coronavirus-Infected Macrophages In Vitro: Possible Relevance to Pathogenesis by CHEUNG, Chung Y, POON, Leo L. M, PEIRIS, Joseph S. M, NG, Iris H. Y, LUK, Winsie, SIA, Sin-Fun, WU, Mavis H. S, CHAN, Kwok-Hung, YUEN, Kwok-Yung, GORDON, Siamon, YI GUAN

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Pathogenesis and transmission of SARS-CoV-2 in golden hamsters by Sia, Sin Fun, Yan, Li-Meng, Chin, Alex W. H., Fung, Kevin, Choy, Ka-Tim, Wong, Alvina Y. L., Kaewpreedee, Prathanporn, Perera, Ranawaka A. P. M., Poon, Leo L. M., Nicholls, John M., Peiris, Malik, Yen, Hui-Ling

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus with high nucleotide identity to SARS-CoV and to SARS-related coronaviruses…”
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Amino Acid Substitutions in Polymerase Basic Protein 2 Gene Contribute to the Pathogenicity of the Novel A/H7N9 Influenza Virus in Mammalian Hosts by Mok, Chris Ka Pun, Lee, Horace Hok Yeung, Lestra, Maxime, Nicholls, John Malcolm, Chan, Michael Chi Wai, Sia, Sin Fun, Zhu, Huachen, Poon, Leo Lit Man, Guan, Yi, Peiris, Joseph Sriyal Malik

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Generation and characterization of influenza A viruses with altered polymerase fidelity by Cheung, Peter P. H., Watson, Simon J., Choy, Ka-Tim, Fun Sia, Sin, Wong, Diana D. Y., Poon, Leo L. M., Kellam, Paul, Guan, Yi, Malik Peiris, J.S., Yen, Hui-Ling

“…Genetic diversity of influenza A viruses (IAV) acquired through the error-prone RNA-dependent RNA polymerase (RdRP) or through genetic reassortment enables…”
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Pathogenicity of the novel A/H7N9 influenza virus in mice by Mok, Chris Ka Pun, Lee, Horace Hok Yeung, Chan, Michael Chi Wai, Sia, Sin Fun, Lestra, Maxime, Nicholls, John Malcolm, Zhu, Huachen, Guan, Yi, Peiris, Joseph Malik Sriyal

“…A novel avian-origin influenza A/H7N9 virus infecting humans was first identified in March 2013 and, as of 30 May 2013, has caused 132 human infections leading…”
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Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters by Su, Wen, Sia, Sin Fun, Schmitz, Aaron J, Bricker, Traci L, Starr, Tyler N, Greaney, Allison J, Turner, Jackson S, Mohammed, Bassem M, Liu, Zhuoming, Choy, Ka Tim, Darling, Tamarand L, Joshi, Astha, Cheng, Ka Man, Wong, Alvina Y. L, Harastani, Houda H, Nicholls, John M, Whelan, Sean P. J, Bloom, Jesse D, Yen, Hui-Ling, Ellebedy, Ali H, Boon, Adrianus C. M

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited…”
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Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis by Mok, Chris Ka Pun, Yen, Hui Ling, Yu, May Yan Mei, Yuen, Kit Man, Sia, Sin Fun, Chan, Michael Chi Wai, Qin, Gang, Tu, Wen Wei, Peiris, Joseph Sriyal Malik

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The R292K Mutation That Confers Resistance to Neuraminidase Inhibitors Leads to Competitive Fitness Loss of A/Shanghai/1/2013 (H7N9) Influenza Virus in Ferrets by Yen, Hui-Ling, Zhou, Jie, Choy, Ka-Tim, Sia, Sin Fun, Teng, Ooiean, Ng, Iris H., Fang, Vicky J., Hu, Yunwen, Wang, Wei, Cowling, Benjamin J., Nicholls, John M., Guan, Yi, Peiris, Joseph Sriyal Malik

“…Background. Neuraminidase (NA) inhibitors are the only licensed therapeutic option for human zoonotic H7N9 infections. An NA-R292K mutation that confers…”
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Limited onward transmission potential of reassortment genotypes from chickens co-infected with H9N2 and H7N9 avian influenza viruses by Su, Wen, Sia, Sin Fun, Choy, Ka-Tim, Ji, Yue, Chen, Dongdong, Lau, Eric Ho Yin, Fu, Guanghua, Huang, Yu, Liu, Jinhua, Peiris, Malik, Pu, Juan, Yen, Hui-Ling

“…The segmented genome of influenza A virus has conferred significant evolutionary advantages to this virus through genetic reassortment, a mechanism that…”
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Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice by Leung, Y H Connie, Nicholls, John M, Ho, Chuk Kwan, Sia, Sin Fun, Mok, Chris K P, Valkenburg, Sophie A, Cheung, Peter, Hui, Kenrie P Y, Chan, Renee W Y, Guan, Y, Akira, S, Peiris, J S Malik

“…Toll-like receptors (TLRs) play an important role in innate immunity to virus infections. We investigated the role of TLR3 in the pathogenesis of H5N1 and…”
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Comparable Fitness and Transmissibility between Oseltamivir-Resistant Pandemic 2009 and Seasonal H1N1 Influenza Viruses with the H275Y Neuraminidase Mutation by WONG, Diana D. Y, CHOY, Ka-Tim, CHAN, Renee W. Y, SIN FUN SIA, CHIU, Hsin-Ping, CHEUNG, Peter P. H, CHAN, Michael C. W, MALIK PEIRIS, J. S, YEN, Hui-Ling

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Experimental challenge of chicken vaccinated with commercially available H5 vaccines reveals loss of protection to some highly pathogenic avian influenza H5N1 strains circulating in Hong Kong/China by Connie Leung, Y.H, Luk, Geraldine, Sia, Sin-Fun, Wu, Yu-On, Ho, Chuk-Kwan, Chow, Kai-Chi, Tang, Shing-Chun, Guan, Yi, Malik Peiris, J.S

“…Highlights • HPAI H5N1 viruses undergo antigenic changes. • These antigenic changes may lead to loss of protection against poultry vaccines. • The needs to…”
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Avian influenza virus directly infects human natural killer cells and inhibits cell activity by Mao, Huawei, Liu, Yinping, Sia, Sin Fun, Peiris, J. S. Malik, Lau, Yu-Lung, Tu, Wenwei

“…Natural killer （NK） cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying…”
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Identifying the species-origin of faecal droppings used for avian influenza virus surveillance in wild-birds by Cheung, Peter P, Leung, Y.H. Connie, Chow, Chun-Kin, Ng, Chi-Fung, Tsang, Chun-Lok, Wu, Yu-On, Ma, Siu-Kit, Sia, Sin-Fun, Guan, Yi, Peiris, J.S.M

“…Abstract Background Avian influenza virus (AIV) surveillance in birds is important for public health. Faecal droppings from wild-birds are more readily…”
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Transmission of SARS-CoV-2 delta variant (AY.127) from pet hamsters to humans, leading to onward human-to-human transmission: a case study by Yen, Hui-Ling, Sit, Thomas H C, Brackman, Christopher J, Chuk, Shirley S Y, Gu, Haogao, Tam, Karina W S, Law, Pierra Y T, Leung, Gabriel M, Peiris, Malik, Poon, Leo L M, Cheng, Samuel M S, Chang, Lydia D J, Krishnan, Pavithra, Ng, Daisy Y M, Liu, Gigi Y Z, Hui, Mani M Y, Ho, Sin Ying, Su, Wen, Sia, Sin Fun, Choy, Ka-Tim, Cheuk, Sammi S Y, Lau, Sylvia P N, Tang, Amy W Y, Koo, Joe C T, Yung, Louise

“…Transmission of SARS-CoV-2 from humans to other mammals, including pet animals, has been reported. However, with the exception of farmed mink, there is no…”
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Defining the sizes of airborne particles that mediate influenza transmission in ferrets by Zhou, Jie, Wei, Jianjian, Choy, Ka-Tim, Sia, Sin Fun, Rowlands, Dewi K., Yu, Dan, Wu, Chung-Yi, Lindsley, William G., Cowling, Benjamin J., McDevitt, James, Peiris, Malik, Li, Yuguo, Yen, Hui-Ling

“…Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance…”
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A(H1N1)pdm09 Influenza Viruses Replicating in Ferret Upper or Lower Respiratory Tract Differed in Onward Transmission Potential by Air by Xie, Chenyi, Su, Wen, Sia, Sin Fun, Choy, Ka-Tim, Morrell, Steven, Zhou, Jie, Peiris, Malik, Bloom, Jesse D, Yen, Hui-Ling

“…Abstract Background A(H1N1)pdm09 influenza viruses replicate efficiently in respiratory epithelia and are transmitted via respiratory droplets and aerosols…”
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