Axonal rearrangement without reexpression of a growth associated marker: evidence from the compression of the retinotectal system in adult goldfish

Growing axons express a number of proteins associated with axonal growth which are thought to be critical for regeneration and sprouting. Whether these proteins are expressed during injury-induced axonal remodeling is tested in this paper. The posterior half of the adult goldfish tectum was removed...

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Bibliographic Details
Published in:	Restorative neurology and neuroscience Vol. 25; no. 5-6; p. 535
Main Authors:	Si, Keyuan, Miotke, Jill A, Meyer, Ronald L, Wang, Ziren
Format:	Journal Article
Language:	English
Published:	Netherlands 2007
Subjects:	Animals Axons - physiology GAP-43 Protein - metabolism Goldfish Nerve Fibers - metabolism Nerve Fibers - physiology Nerve Regeneration - physiology Optic Nerve Injuries - metabolism Optic Nerve Injuries - pathology Optic Nerve Injuries - physiopathology Retina - metabolism Retina - pathology Serine - metabolism Time Factors Visual Pathways - physiopathology
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Summary:	Growing axons express a number of proteins associated with axonal growth which are thought to be critical for regeneration and sprouting. Whether these proteins are expressed during injury-induced axonal remodeling is tested in this paper. The posterior half of the adult goldfish tectum was removed leaving the anterior half intact. This causes optic fibers from nasal retina, which project to posterior tectum, to displace temporal fibers from the anterior remnant and form a compressed retinotopic projection of the entire retina onto the anterior tectum. Immunohistochemistry using an antibody shown here to recognize growing and regenerating fibers in goldfish was used to monitor optic fibers. As expected, surgery induced reactivity in the axotomized nasal axons peaking at 1 month which returned to normal at 2 months when compression was completed. Unexpectedly, axons from temporal retina showed no detectable reactivity even though they were induced to grow anteriorly by the invading nasal fibers. Extensive axonal remodeling and synaptic rearrangement can occur without reentering the growth state associated with axonal growth and regeneration.
ISSN:	0922-6028