Search Results - "Shyy, John Y J"

Epigenetic Regulation: A New Frontier for Biomedical Engineers by Chen, Zhen, Li, Shuai, Subramaniam, Shankar, Shyy, John Y.-J, Chien, Shu

“…Gene expression in mammalian cells depends on the epigenetic status of the chromatin, including DNA methylation, histone modifications, promoter-enhancer…”
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Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation by Miller, Yury I, Shyy, John Y.-J

“…Oxidized low-density lipoprotein (OxLDL), which contains hundreds of different oxidized lipid molecules, is a hallmark of hyperlipidemia and atherosclerosis…”
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AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice by Li, Yu, Xu, Shanqin, Mihaylova, Maria M., Zheng, Bin, Hou, Xiuyun, Jiang, Bingbing, Park, Ogyi, Luo, Zhijun, Lefai, Etienne, Shyy, John Y.-J., Gao, Bin, Wierzbicki, Michel, Verbeuren, Tony J., Shaw, Reuben J., Cohen, Richard A., Zang, Mengwei

“…AMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid metabolic disorders in type 1 and type 2 diabetes. Here we demonstrate…”
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miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease by He, Ming, Chen, Zhen, Martin, Marcy, Zhang, Jin, Sangwung, Panjamaporn, Woo, Brian, Tremoulet, Adriana H, Shimizu, Chisato, Jain, Mukesh K, Burns, Jane C, Shyy, John Y.-J

“…RATIONALE:Endothelial–mesenchymal transition (EndoMT) is implicated in myofibroblast-like cell–mediated damage to the coronary arterial wall in acute Kawasaki…”
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AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension by Zhang, Jiao, Dong, Jianjie, Martin, Marcy, He, Ming, Gongol, Brendan, Marin, Traci L, Chen, Lili, Shi, Xinxing, Yin, Yanjun, Shang, Fenqing, Wu, Yan, Huang, Hsi-Yuan, Zhang, Jin, Zhang, Yu, Kang, Jian, Moya, Esteban A, Huang, Hsien-Da, Powell, Frank L, Chen, Zhen, Thistlethwaite, Patricia A, Yuan, Zu-Yi, Shyy, John Y-J

“…Endothelial dysfunction plays an integral role in pulmonary hypertension (PH). AMPK (AMP-activated protein kinase) and ACE2 (angiotensin-converting enzyme 2)…”
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MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension by Shen, Hui, Zhang, Jiao, Wang, Chen, Jain, Pritesh P., Xiong, Mingmei, Shi, Xinxing, Lei, Yuyang, Chen, Shanshan, Yin, Qian, Thistlethwaite, Patricia A., Wang, Jian, Gong, Kaizheng, Yuan, Zu-Yi, Yuan, Jason X.-J., Shyy, John Y.-J.

“…BACKGROUND:Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II, a potent vasoconstrictor, to angiotensin-(1–7) and is also a membrane protein that…”
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Systems biology analysis of longitudinal functional response of endothelial cells to shear stress by Ajami, Nassim E., Gupta, Shakti, Maurya, Mano R., Nguyen, Phu, Li, Julie Yi-Shuan, Shyy, John Y.-J., Chen, Zhen, Chien, Shu, Subramaniam, Shankar

“…Blood flow and vascular shear stress patterns play a significant role in inducing and modulating physiological responses of endothelial cells (ECs). Pulsatile…”
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Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility by Li, Zhao, Martin, Marcy, Zhang, Jin, Huang, Hsi-Yuan, Bai, Liang, Zhang, Jiao, Kang, Jian, He, Ming, Li, Jie, Maurya, Mano R, Gupta, Shakti, Zhou, Guangjin, Sangwung, Panjamaporn, Xu, Yong-Jiang, Lei, Ting, Huang, Hsien-Da, Jain, Mohit, Jain, Mukesh K, Subramaniam, Shankar, Shyy, John Y.-J

“…BACKGROUND:Atherosclerosis is a multifaceted inflammatory disease involving cells in the vascular wall (eg, endothelial cells [ECs]), as well as circulating…”
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Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications by He, Ming, Huang, Tse-Shun, Li, Shuai, Hong, Hsiao-Chin, Chen, Zhen, Martin, Marcy, Zhou, Xin, Huang, Hsi-Yuan, Su, Shu-Han, Zhang, Jiao, Wang, Wei-Ting, Kang, Jian, Huang, Hsien-Da, Zhang, Jin, Chien, Shu, Shyy, John Y.-J

“…OBJECTIVE—The topographical distribution of atherosclerosis in vasculature underscores the importance of shear stress in regulating endothelium. With a systems…”
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miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4 by CHEN, Hsin-Yi, LIN, Yu-Min, SHYY, John Y.-J, LIANG, Jin-Tung, CHEN, Ruey-Hwa, CHUNG, Hsiang-Ching, LANG, Yaw-Dong, LIN, Ching-Jung, HUANG, John, WANG, Wei-Chi, LIN, Feng-Mao, ZHEN CHEN, HUANG, Hsien-Da

“…Metastasis is the major cause of poor prognosis in colorectal cancer (CRC), and increasing evidence supports the contribution of miRNAs to cancer progression…”
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Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a by WEI WU, HAN XIAO, LI, Yi-Shuan, SHU CHIEN, GARCIA-CARDENA, Guillermo, SHYY, John Y.-J, LAGUNA-FERNANDEZ, Andres, VILLARREAL, Guadalupe, WANG, Kuei-Chun, GEARY, Greg G, YUZHI ZHANG, WANG, Wei-Chi, HUANG, Hsien-Da, JING ZHOU

“…Upregulated by atheroprotective flow, the transcription factor Krüppel-like factor 2 (KLF2) is crucial for maintaining endothelial function. MicroRNAs (miRNAs)…”
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Mechanosensitive microRNAs—role in endothelial responses to shear stress and redox state by Marin, Traci, Gongol, Brendan, Chen, Zhen, Woo, Brian, Subramaniam, Shankar, Chien, Shu, Shyy, John Y.-J.

“…Endothelial functions are highly regulated by imposed shear stress in vivo. The characteristics of shear stress determine mechanotransduction events that…”
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Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension by Wang, Xiao-Jian, Lian, Tian-Yu, Jiang, Xin, Liu, Shao-Fei, Li, Su-Qi, Jiang, Rong, Wu, Wen-Hui, Ye, Jue, Cheng, Chun-Yan, Du, Yao, Xu, Xi-Qi, Wu, Yan, Peng, Fu-Hua, Sun, Kai, Mao, Yi-Min, Yu, Huan, Liang, Chen, Shyy, John Y-J, Zhang, Shu-Yang, Zhang, Xue, Jing, Zhi-Cheng

“…Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease with high heritability. Although several predisposing genes have been linked to IPAH, the…”
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MicroRNA-21 targets peroxisome proliferators-activated receptor-α in an autoregulatory loop to modulate flow-induced endothelial inflammation by Zhou, Jing, Wang, Kuei-Chun, Wu, Wei, Subramaniam, Shankar, Shyy, John Y.-J., Chiu, Jeng-Jiann, Li, Julie Y.-S., Chien, Shu

“…Adhesion of circulating monocytes to vascular endothelial cells (ECs) is a critical event leading to vascular inflammation and, hence, development of…”
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Halofuginone, a promising drug for treatment of pulmonary hypertension by Jain, Pritesh P., Zhao, Tengteng, Xiong, Mingmei, Song, Shanshan, Lai, Ning, Zheng, Qiuyu, Chen, Jiyuan, Carr, Shane G., Babicheva, Aleksandra, Izadi, Amin, Rodriguez, Marisela, Rahimi, Shamin, Balistrieri, Francesca, Rahimi, Shayan, Simonson, Tatum, Valdez‐Jasso, Daniela, Thistlethwaite, Patricia A., Shyy, John Y.‐J., Wang, Jian, Makino, Ayako, Yuan, Jason X.‐J.

“…Background and Purpose Halofuginone is a febrifugine derivative originally isolated from Chinese traditional herb Chang Shan that exhibits anti‐hypertrophic,…”
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Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization by Bai, Liang, Li, Zhao, Li, Qianwei, Guan, Hua, Zhao, Sihai, Liu, Ruihan, Wang, Rong, Zhang, Jin, Jia, Yuzhi, Fan, Jianglin, Wang, Nanping, Reddy, Janardan K, Shyy, John Y.-J, Liu, Enqi

“…OBJECTIVE—MED1 (mediator 1) interacts with transcription factors to regulate transcriptional machinery. The role of MED1 in macrophage biology and the relevant…”
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Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing by Wang, Yingxiao, Shyy, John Y-J, Chien, Shu

“…Fluorescence proteins (FPs) have been widely used for live-cell imaging in the past decade. This review summarizes the recent advances in FP development and…”
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Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children by Kim, Jihoon, Shimizu, Chisato, He, Ming, Wang, Hao, Hoffman, Hal M, Tremoulet, Adriana H, Shyy, John Y-J, Burns, Jane C

“…Although Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) share some clinical manifestations, their cardiovascular outcomes are…”
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MicroRNA-92a Mediates Endothelial Dysfunction in CKD by Shang, Fenqing, Wang, Shen-Chih, Hsu, Chien-Yi, Miao, Yifei, Martin, Marcy, Yin, Yanjun, Wu, Chih-Cheng, Wang, Yun-Ting, Wu, Gaihong, Chien, Shu, Huang, Hsien-Da, Tarng, Der-Cherng, Shiu, Yan-Ting, Cheung, Alfred K, Huang, Po-Hsun, Chen, Zhen, Shyy, John Y-J

“…CKD is an independent risk factor for cardiovascular disease (CVD). The accumulation of uremic toxins in CKD induces oxidative stress and endothelial…”
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Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility by Xiao, Han, Lu, Min, Lin, Ting Yang, Chen, Zhen, Chen, Gang, Wang, Wei-Chi, Marin, Traci, Shentu, Tzu-pin, Wen, Liang, Gongol, Brendan, Sun, Wei, Liang, Xiao, Chen, Ju, Huang, Hsien-Da, Pedra, Joao H.F, Johnson, David A, Shyy, John Y-J

“…BACKGROUND—The molecular basis for the focal nature of atherosclerotic lesions is poorly understood. Here, we explored whether disturbed flow patterns activate…”
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