Search Results - "Shymko, R M"

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor by Ish-Shalom, D, Christoffersen, C T, Vorwerk, P, Sacerdoti-Sierra, N, Shymko, R M, Naor, D, De Meyts, P

“…Insulin has traditionally been considered as a hormone essential for metabolic regulation, while the insulin-like growth factors (IGF-I and IGF-II) are…”
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Role of the time factor in signaling specificity: Application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases by De Meyts, Pierre, Christoffersen, Claus T., Ursø, Birgitte, Wallach, Brenda, Grønskov, Karen, Yakushiji, Fumiatsu, Shymko, Ronald M.

“…The signal transduction pathways activated by hormones, growth factors, and cytokines show an extraordinary degree of cross-talk and redundancy. This review…”
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Biological effects of human growth hormone in rat adipocyte precursor cells and newly differentiated adipocytes in primary culture by Wabitsch, Martin, Heinze, Eberhard, Hauner, Hans, Shymko, Ronald M., Teller, Walter M., De Meyts, Pierre, Ilondo, Mapoko M.

“…The effects of human growth hormone (hGH) on proliferation and differentiation of primary adipocyte precursor cells isolated from rat epididymal fat pads were…”
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Identification of a ligand-binding region of the human insulin receptor encoded by the second exon of the gene by De Meyts, P, Gu, J L, Shymko, R M, Kaplan, B E, Bell, G I, Whittaker, J

“…Structure-function studies of the insulin molecule indicate that an insulin B chain domain comprising residues 22-26 is involved both in binding to the insulin…”
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Circadian gating of S phase in human ovarian cancer by KLEVECZ, R. R, SHYMKO, R. M, BLUMENFELD, D, BRALY, P. S

“…Cell proliferation in 30 patients with ovarian cancer was analyzed using flow cytometry to determine changes in the percentage of cells in S phase. By this…”
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Tissue population configuration as a modifier of organ dose response by Archambeau, J O, Shymko, R M

“…Organ tissue populations exist in different spatial configurations. There are the idealized "volume" configuration (bone marrow), the "monolayer" (skin basal…”
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Mutation of arginine 86 to proline in the insulin receptor alpha subunit causes lack of transport of the receptor to the plasma membrane, loss of binding affinity and a constitutively activated tyrosine kinase in transfected cells by Grønskov, K, Vissing, H, Shymko, R M, Tornqvist, H, De Meyts, P

“…We have investigated the role of Ser 85 and Arg 86 of the human insulin receptor (HIR) in insulin binding and tyrosine kinase activity by mutational analysis…”
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Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes by Ilondo, M M, Damholt, A B, Cunningham, B A, Wells, J A, De Meyts, P, Shymko, R M

“…Binding of GH to its cell surface receptors is thought to result in the formation of a complex comprised of one molecule of hormone per two molecules of…”
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Cellular and geometric control of tissue growth and mitotic instability by Shymko, R M

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Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor by Christoffersen, C T, Bornfeldt, K E, Rotella, C M, Gonzales, N, Vissing, H, Shymko, R M, ten Hoeve, J, Groffen, J, Heisterkamp, N, De Meyts, P

“…Insulin and insulin-like growth factor-I (IGF-I) share a spectrum of metabolic and growth-promoting effects, mediated through homologous receptors that belong…”
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Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding by Shymko, R M, Dumont, E, De Meyts, P, Dumont, J E

“…Mitogenic signalling through the insulin receptor is enhanced compared with metabolic signalling for insulin analogues having slower dissociation kinetics than…”
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Quasi-exponential generation time distributions from a limit cycle oscillator by Klevecz, R R, Shymko, R M

“…In spite of the apparently random behaviour and the often exponential distribution of generation times expressed in cell populations, there is evidence for…”
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Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways by Shymko, R M, De Meyts, P, Thomas, R

“…We present a method for logical analysis of signal-transduction networks, focusing on metabolic and mitogenic signalling by the insulin receptor, with specific…”
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Field size dependence of radiation sensitivity and dose fractionation response in skin by Shymko, R M, Hauser, D L, Archambeau, J O

“…Four sets of data from the literature were analyzed to assess the effects of field size on dose tolerance and dose fraction size dependence in irradiated skin…”
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Mechanism of insulin and IGF-I receptor activation and signal transduction specificity. Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling by De Meyts, P, Ursø, B, Christoffersen, C T, Shymko, R M

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Lack of correlation between basal cell survival and gross response in irradiated swine skin by Shymko, R M, Hauser, D L, Archambeau, J O

“…The relationship between basal cell survival and gross response in irradiated swine skin was tested by comparing dose survival curves derived from time-dose…”
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Biosensor Measurement of the Binding of Insulin-like Growth Factors I and II and Their Analogues to the Insulin-like Growth Factor-binding Protein-3 by Heding, A, Gill, R, Ogawa, Y, De Meyts, P, Shymko, R M

“…Most insulin-like growth factor (IGF) molecules in the circulation are found in a 150-kDa complex containing IGF-binding protein-3 (IGFBP-3) and an acid-labile…”
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Low clonogenic fraction need not imply survival/healing correlation by Shymko, R M, Archambeau, J O

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Mitotic delay following inhibition by 5'-fluorodeoxyuridine of S-phase in Physarum is not due to delay in termination of S-phase by Kauffman, S A, Shymko, R M

“…It has been known for several years that inhibition by 5'-fluorodeoxyuridine (FdUrd) of DNA synthesis in plasmodia of Physarum polycephalum delays subsequent…”
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The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction by De Meyts, P, Wallach, B, Christoffersen, C T, Ursø, B, Grønskov, K, Latus, L J, Yakushiji, F, Ilondo, M M, Shymko, R M

“…The nonclassical binding kinetics of IGF-I and insulin to their respective receptors, suggestive of negative cooperativity, can be readily explained by our…”
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