Search Results - "Shykind, Benjamin M"

Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice by Bashkirova, Elizaveta V, Klimpert, Nell, Monahan, Kevin, Campbell, Christine E, Osinski, Jason, Tan, Longzhi, Schieren, Ira, Pourmorady, Ariel, Stecky, Beka, Barnea, Gilad, Xie, Xiaoliang Sunney, Abdus-Saboor, Ishmail, Shykind, Benjamin M, Marlin, Bianca J, Gronostajski, Richard M, Fleischmann, Alexander, Lomvardas, Stavros

“…Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles…”
Get full text

An Expression Refinement Process Ensures Singular Odorant Receptor Gene Choice by Abdus-Saboor, Ishmail, Al Nufal, Mohammed J., Agha, Maha V., Ruinart de Brimont, Marion, Fleischmann, Alexander, Shykind, Benjamin M.

“…Odorant receptor (OR) gene choice in mammals is a paradigmatic example of monogenic and monoallelic transcriptional selection, in which each olfactory sensory…”
Get full text

Gene Switching and the Stability of Odorant Receptor Gene Choice by Shykind, Benjamin M, Rohani, S.Christy, O'Donnell, Sean, Nemes, Adriana, Mendelsohn, Monica, Sun, Yonghua, Axel, Richard, Barnea, Gilad

“…Individual olfactory sensory neurons express only a single odorant receptor from a large family of genes, and this singularity is an essential feature in…”
Get full text

Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results by Sevigny, Jeffrey, Uspenskaya, Olga, Heckman, Laura Dean, Wong, Li Chin, Hatch, Daniel A., Tewari, Ambika, Vandenberghe, Rik, Irwin, David J., Saracino, Dario, Le Ber, Isabelle, Ahmed, Rebekah, Rohrer, Jonathan D., Boxer, Adam L., Boland, Sebastian, Sheehan, Patricia, Brandes, Alissa, Burstein, Suzanne R., Shykind, Benjamin M., Kamalakaran, Sitharthan, Daniels, Carter W., David Litwack, E., Mahoney, Erin, Velaga, Jenny, McNamara, Ilan, Sondergaard, Patricia, Sajjad, Syed A., Kobayashi, Yvonne M., Abeliovich, Asa, Hefti, Franz

“…GRN mutations cause progranulin haploinsufficiency, which eventually leads to frontotemporal dementia (FTD-GRN). PR006 is an investigational gene therapy…”
Get full text

Regulation of odorant receptors: one allele at a time by Shykind, Benjamin M

“…The odorant receptors (ORs) make up the largest gene family in mammals. Each olfactory sensory neuron chooses just one OR from the more than 1000 possibilities…”
Get full text

Olfactory deficits cause anxiety-like behaviors in mice by Glinka, Meredith E, Samuels, Benjamin A, Diodato, Assunta, Teillon, Jérémie, Feng Mei, Dan, Shykind, Benjamin M, Hen, René, Fleischmann, Alexander

“…Anxiety disorders are characterized by persistent fear in the absence of immediate threat and represent the most common psychiatric diseases, with an estimated…”
Get full text

Mice with a “Monoclonal Nose”: Perturbations in an Olfactory Map Impair Odor Discrimination by Fleischmann, Alexander, Shykind, Benjamin M., Sosulski, Dara L., Franks, Kevin M., Glinka, Meredith E., Mei, Dan Feng, Sun, Yonghua, Kirkland, Jennifer, Mendelsohn, Monica, Albers, Mark W., Axel, Richard

“…We have altered the neural representation of odors in the brain by generating a mouse with a “monoclonal nose” in which greater than 95% of the sensory neurons…”
Get full text

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels by Young, Janet M, Shykind, Benjamin M, Lane, Robert P, Tonnes-Priddy, Lori, Ross, Joseph A, Walker, Megan, Williams, Eleanor M, Trask, Barbara J

“…The olfactory receptor gene family is one of the largest in the mammalian genome. Previous computational analyses have identified approximately 1,500 mouse…”
Get full text

Regulation of odorant receptors: one allele at a time by Shykind, Benjamin M.

Get full text

Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice by Bashkirova, Elizaveta V, Klimpert, Nell, Monahan, Kevin, Campbell, Christine E, Osinski, Jason, Tan, Longzhi, Schieren, Ira, Pourmorady, Ariel, Stecky, Beka, Barnea, Gilad, Xie, Xiaoliang Sunney, Abdus-Saboor, Ishmail, Shykind, Benjamin M, Marlin, Bianca J, Gronostajski, Richard M, Fleischmann, Alexander, Lomvardas, Stavros

“…Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles…”
Get full text

A Negative Cofactor Containing Dr1/p19 Modulates Transcription with TFIIA in a Promoter-specific Fashion by Kim, Jaesang, Parvin, Jeffrey D., Shykind, Benjamin M., Sharp, Phillip A.

“…An activity that modulated the relative levels of transcription from the adenovirus major late promoter (MLP), and the immunoglobulin heavy chain µ promoter…”
Get full text

Regulation of odorant receptors : one allele at a time: Epigenetics by SHYKIND, Benjamin M

Get full text

Activation of the TFIID-TFIIA complex with HMG-2 by Shykind, B M, Kim, J, Sharp, P A

“…The nonhistone chromosomal protein HMG-2 was identified as a factor necessary for activation in a defined transcription reaction in vitro containing RNA…”
Get full text

Topoisomerase I enhances TFIID-TFIIA complex assembly during activation of transcription by Shykind, B M, Kim, J, Stewart, L, Champoux, J J, Sharp, P A

“…The mechanism of coactivation by DNA topoisomerase I (topo I) was examined in a highly defined in vitro transcription system containing Pol II and purified…”
Get full text

Multiple sets of basal factors initiate transcription by RNA polymerase II by PARVIN, J. D, SHYKIND, B. M, MEYERS, R. E, JAESANG KIM, SHARP, P. A

“…The minimal requirements for transcription initiation from supercoiled templates were determined for the two major forms of TATA-binding factors found in cell…”
Get full text