Search Results - "Shyh‐Chang, Ng"

Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review by Li, Chun‐wei, Yu, Kang, Shyh‐Chang, Ng, Jiang, Zongmin, Liu, Taoyan, Ma, Shilin, Luo, Lanfang, Guang, Lu, Liang, Kun, Ma, Wenwu, Miao, Hefan, Cao, Wenhua, Liu, Ruirui, Jiang, Ling‐juan, Yu, Song‐lin, Li, Chao, Liu, Hui‐jun, Xu, Long‐yu, Liu, Rong‐ji, Zhang, Xin‐yuan, Liu, Gao‐shan

“…Age‐associated obesity and muscle atrophy (sarcopenia) are intimately connected and are reciprocally regulated by adipose tissue and skeletal muscle…”
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Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types by Loh, Kyle M., Chen, Angela, Koh, Pang Wei, Deng, Tianda Z., Sinha, Rahul, Tsai, Jonathan M., Barkal, Amira A., Shen, Kimberle Y., Jain, Rajan, Morganti, Rachel M., Shyh-Chang, Ng, Fernhoff, Nathaniel B., George, Benson M., Wernig, Gerlinde, Salomon, Rachel E.A., Chen, Zhenghao, Vogel, Hannes, Epstein, Jonathan A., Kundaje, Anshul, Talbot, William S., Beachy, Philip A., Ang, Lay Teng, Weissman, Irving L.

“…Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive…”
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The Metabaging Cycle by Ma, Shilin, Shyh‐Chang, Ng

“…Degenerating or senescent myocytes will also secrete a variety of pro-inflammatory factors and chemokines, activating and recruiting a variety of inflammatory…”
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Chromatin‐modifying drugs and metabolites in cell fate control by Yao, Ziyue, Chen, Yu, Cao, Wenhua, Shyh‐Chang, Ng

“…For multicellular organisms, it is essential to produce a variety of specialized cells to perform a dazzling panoply of functions. Chromatin plays a vital role…”
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An RNA methylation code to regulate protein translation and cell fate by Song, Dan, Shyh‐Chang, Ng

“…32 In epidermal stem cells, NSUN2-mediated m5C protects tRNA from cleavage into non-coding 5′tRNA fragments, thereby affecting global protein synthesis…”
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Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression by Zhang, Wen Cai, Chin, Tan Min, Yang, Henry, Nga, Min En, Lunny, Declan Patrick, Lim, Edwin Kok Hao, Sun, Li Li, Pang, Yin Huei, Leow, Yi Ning, Malusay, Shanneen Rossellini Y, Lim, Priscilla Xin Hui, Lee, Jeravan Zili, Tan, Benedict Jian Wei, Shyh-Chang, Ng, Lim, Elaine Hsuen, Lim, Wan Teck, Tan, Daniel Shao Weng, Tan, Eng Huat, Tai, Bee Choo, Soo, Ross Andrew, Tam, Wai Leong, Lim, Bing

“…The tumour-initiating cell (TIC) model accounts for phenotypic and functional heterogeneity among tumour cells. MicroRNAs (miRNAs) are regulatory molecules…”
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The Lin28/let-7 Axis Regulates Glucose Metabolism by Zhu, Hao, Shyh-Chang, Ng, Segrè, Ayellet V., Shinoda, Gen, Shah, Samar P., Einhorn, William S., Takeuchi, Ayumu, Engreitz, Jesse M., Hagan, John P., Kharas, Michael G., Urbach, Achia, Thornton, James E., Triboulet, Robinson, Gregory, Richard I., Altshuler, David, Daley, George Q.

“…The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/ b promote malignancy by inhibiting…”
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Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis by Wu, Jun, Song, Dingyun, Li, Zhongwen, Guo, Baojie, Xiao, Yani, Liu, Wenjing, Liang, Lingmin, Feng, Chunjing, Gao, Tingting, Chen, Yanxia, Li, Ying, Wang, Zai, Wen, Jianyan, Yang, Shengnan, Liu, Peipei, Wang, Lei, Wang, Yukai, Peng, Liang, Stacey, Glyn Nigel, Hu, Zheng, Feng, Guihai, Li, Wei, Huo, Yan, Jin, Ronghua, Shyh-Chang, Ng, Zhou, Qi, Wang, Liu, Hu, Baoyang, Dai, Huaping, Hao, Jie

“…Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders, including COVID-19. However, there are still no effective…”
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Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis by Zhang, Wen Cai, Shyh-Chang, Ng, Yang, He, Rai, Amit, Umashankar, Shivshankar, Ma, Siming, Soh, Boon Seng, Sun, Li Li, Tai, Bee Choo, Nga, Min En, Bhakoo, Kishore Kumar, Jayapal, Senthil Raja, Nichane, Massimo, Yu, Qiang, Ahmed, Dokeu A., Tan, Christie, Sing, Wong Poo, Tam, John, Thirugananam, Agasthian, Noghabi, Monireh Soroush, Huei Pang, Yin, Ang, Haw Siang, Mitchell, Wayne, Robson, Paul, Kaldis, Philipp, Soo, Ross Andrew, Swarup, Sanjay, Lim, Elaine Hsuen, Lim, Bing

“…Identification of the factors critical to the tumor-initiating cell (TIC) state may open new avenues in cancer therapy. Here we show that the metabolic enzyme…”
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Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention by Li, Chun‐wei, Yu, Kang, Shyh‐Chang, Ng, Li, Guo‐xun, Jiang, Ling‐juan, Yu, Song‐lin, Xu, Long‐yu, Liu, Rong‐ji, Guo, Zi‐jian, Xie, Hai‐yan, Li, Rong‐rong, Ying, Jie, Li, Kang, Li, Dong‐jing

“…Background Ageing, chronic diseases, prolonged inactivity, and inadequate nutrition pose a severe threat to skeletal muscle health and function. To date,…”
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Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies by Daley, George Q, Zhu, Hao, Shah, Samar, Shyh-Chang, Ng, Shinoda, Gen, Einhorn, William S, Viswanathan, Srinivas R, Takeuchi, Ayumu, Grasemann, Corinna, Rinn, John L, Lopez, Mary F, Hirschhorn, Joel N, Palmert, Mark R

“…Recently, genome-wide association studies have implicated the human LIN28B locus in regulating height and the timing of menarche. LIN28B and its homolog LIN28A…”
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HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer by Xu, Chang, Ooi, Wen Fong, Qamra, Aditi, Tan, Jing, Chua, Benjamin Yan-Jiang, Ho, Shamaine Wei Ting, Das, Kakoli, Adam Isa, Zul Fazreen, Li, Zhimei, Yao, Xiaosai, Yan, Tingdong, Xing, Manjie, Huang, Kie Kyon, Lin, Joyce Suling, Nandi, Tannistha, Tay, Su Ting, Lee, Ming Hui, Tan, Angie Lay Keng, Ong, Xuewen, Ashktorab, Hassan, Smoot, Duane, Li, Shang, Ng, Shyh-Chang, Teh, Bin Tean, Tan, Patrick

“…Gastric cancer (GC) is a leading cause of cancer mortality. Previous studies have shown that is specifically overexpressed in GC and functionally required for…”
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Observations that suggest a contribution of altered dermal papilla mitochondrial function to androgenetic alopecia by Chew, Elaine G. Y., Lim, Tze Chiun, Leong, Meng Fatt, Liu, Xingliang, Sia, Yee Yen, Leong, See Ting, Yan‐Jiang, Benjamin C., Stoecklin, Celine, Borhan, Rosa, Heilmann‐Heimbach, Stefanie, Nöthen, Markus M., Viasnoff, Virgile, Shyh‐Chang, Ng, Wan, Andrew C. A., Philpott, Michael P., Hillmer, Axel M.

“…Androgenetic alopecia (AGA) is a prevalent hair loss condition in males that develops due to the influence of androgens and genetic predisposition. With the…”
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Machine learning‐based phenotypic screening for postmitotic growth inducers uncover vitamin D3 metabolites as small molecule ribosome agonists by Jiang, Zongmin, Zhang, Liping, Yao, Ziyue, Cao, Wenhua, Ma, Shilin, Chen, Yu, Guang, Lu, Zheng, Zipeng, Li, Chunwei, Yu, Kang, Shyh‐Chang, Ng

“…Objectives To restore tissue growth without increasing the risk for cancer during aging, there is a need to identify small molecule drugs that can increase…”
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Fetal Deficiency of Lin28 Programs Life‐Long Aberrations in Growth and Glucose Metabolism by Shinoda, Gen, Shyh‐Chang, Ng, Soysa, T. Yvanka de, Zhu, Hao, Seligson, Marc T., Shah, Samar P., Abo‐Sido, Nora, Yabuuchi, Akiko, Hagan, John P., Gregory, Richard I., Asara, John M., Cantley, Lewis C., Moss, Eric G., Daley, George Q.

“…LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over‐expression of Lin28a…”
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Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor by Liu, Zunpeng, Li, Wei, Geng, Lingling, Sun, Liang, Wang, Qiaoran, Yu, Yang, Yan, Pengze, Liang, Chuqian, Ren, Jie, Song, Moshi, Zhao, Qian, Lei, Jinghui, Cai, Yusheng, Li, Jiaming, Yan, Kaowen, Wu, Zeming, Chu, Qun, Li, Jingyi, Wang, Si, Li, Chunyi, Han, Jing-Dong J., Hernandez-Benitez, Reyna, Shyh-Chang, Ng, Belmonte, Juan Carlos Izpisua, Zhang, Weiqi, Qu, Jing, Liu, Guang-Hui

“…Regenerative capacity declines throughout evolution and with age. In this study, we asked whether metabolic programs underlying regenerative capability might…”
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The metabolic programming of stem cells by Shyh-Chang, Ng, Ng, Huck-Hui

“…Advances in metabolomics have deepened our understanding of the roles that specific modes of metabolism play in programming stem cell fates. Here, we review…”
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Precise let-7 expression levels balance organ regeneration against tumor suppression by Wu, Linwei, Nguyen, Liem H, Zhou, Kejin, de Soysa, T Yvanka, Li, Lin, Miller, Jason B, Tian, Jianmin, Locker, Joseph, Zhang, Shuyuan, Shinoda, Gen, Seligson, Marc T, Zeitels, Lauren R, Acharya, Asha, Wang, Sam C, Mendell, Joshua T, He, Xiaoshun, Nishino, Jinsuke, Morrison, Sean J, Siegwart, Daniel J, Daley, George Q, Shyh-Chang, Ng, Zhu, Hao

“…The in vivo roles for even the most intensely studied microRNAs remain poorly defined. Here, analysis of mouse models revealed that let-7, a large and ancient…”
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Muscle Injuries Induce a Prostacyclin‐PPARγ/PGC1a‐FAO Spike That Boosts Regeneration by Luo, Lanfang, Chua, Yan‐Jiang Benjamin, Liu, Taoyan, Liang, Kun, Chua, Min‐Wen Jason, Ma, Wenwu, Goh, Jun‐Wei, Wang, Yuefan, Su, Jiali, Ho, Ying Swan, Li, Chun‐Wei, Liu, Ke Hui, Teh, Bin Tean, Yu, Kang, Shyh‐Chang, Ng

“…It is well‐known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise and acute injury are…”
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Lin28: Primal Regulator of Growth and Metabolism in Stem Cells by Shyh-Chang, Ng, Daley, George Q.

“…In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors that define stemness in several tissue lineages. Lin28 proteins…”
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