Search Results - "Shuvaev, Anton N"

Blood-Brain Barrier and Neurovascular Unit In Vitro Models for Studying Mitochondria-Driven Molecular Mechanisms of Neurodegeneration by Salmina, Alla B, Kharitonova, Ekaterina V, Gorina, Yana V, Teplyashina, Elena A, Malinovskaya, Natalia A, Khilazheva, Elena D, Mosyagina, Angelina I, Morgun, Andrey V, Shuvaev, Anton N, Salmin, Vladimir V, Lopatina, Olga L, Komleva, Yulia K

“…Pathophysiology of chronic neurodegeneration is mainly based on complex mechanisms related to aberrant signal transduction, excitation/inhibition imbalance,…”
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Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1 by Shuvaev, Anton N., Belozor, Olga S., Mozhei, Oleg, Yakovleva, Dariya A., Potapenko, Ilya V., Shuvaev, Andrey N., Smolnikova, Marina V., Salmin, Vladimir V., Salmina, Alla B., Hirai, Hirokazu, Teschemacher, Anja G., Kasparov, Sergey

“…Bergmann glia (BG) are highly specialized radial astrocytes of the cerebellar cortex, which play a key role in the uptake of synaptic glutamate via the…”
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NLRP3 Inflammasome Blocking as a Potential Treatment of Central Insulin Resistance in Early-Stage Alzheimer's Disease by Komleva, Yulia K, Potapenko, Ilia V, Lopatina, Olga L, Gorina, Yana V, Chernykh, Anatoly, Khilazheva, Elena D, Salmina, Alla B, Shuvaev, Anton N

“…Alzheimer's disease (AD) is a devastating neurodegenerative disorder. In recent years, attention of researchers has increasingly been focused on studying the…”
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Plasticity of Adipose Tissue-Derived Stem Cells and Regulation of Angiogenesis by Panina, Yulia A, Yakimov, Anton S, Komleva, Yulia K, Morgun, Andrey V, Lopatina, Olga L, Malinovskaya, Natalia A, Shuvaev, Anton N, Salmin, Vladimir V, Taranushenko, Tatiana E, Salmina, Alla B

“…Adipose tissue is recognized as an important organ with metabolic, regulatory, and plastic roles. Adipose tissue-derived stem cells (ASCs) with self-renewal…”
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Protective Effect of Memantine on Bergmann Glia and Purkinje Cells Morphology in Optogenetic Model of Neurodegeneration in Mice by Shuvaev, Anton N., Belozor, Olga S., Mozhei, Oleg I., Khilazheva, Elena D., Shuvaev, Andrey N., Fritsler, Yana V., Kasparov, S.

“…Spinocerebellar ataxias are a family of fatal inherited diseases affecting the brain. Although specific mutated proteins are different, they may have a common…”
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Memantine suppresses the excitotoxicity but fails to rescue the ataxic phenotype in SCA1 model mice by Belozor, Olga S., Vasilev, Alex, Mileiko, Alexandra G., Mosina, Lyudmila D., Mikhailov, Ilya G., Ox, Darius A., Boitsova, Elizaveta B., Shuvaev, Andrey N., Teschemacher, Anja G., Kasparov, Sergey, Shuvaev, Anton N.

“…Spinocerebellar ataxia type 1 (SCA1) is a debilitating neurodegenerative disorder of the cerebellum and brainstem. Memantine has been proposed as a potential…”
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Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells by Takahashi, Nobutaka, Shuvaev, Anton N., Konno, Ayumu, Matsuzaki, Yasunori, Watanave, Masashi, Hirai, Hirokazu

“…Cerebellar Purkinje cells (PCs) express two members of the classical protein kinase C (cPKC) subfamily, namely, PKCα and PKCγ. Previous studies on PKCγ…”
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Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling by Malinovskaya, Natalia A, Komleva, Yulia K, Salmin, Vladimir V, Morgun, Andrey V, Shuvaev, Anton N, Panina, Yulia A, Boitsova, Elizaveta B, Salmina, Alla B

“…Currently, there is a considerable interest to the assessment of blood-brain barrier (BBB) development as a part of cerebral angiogenesis developmental…”
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Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1 by Shuvaev, Anton N., Belozor, Olga S., Mozhei, Oleg I., Shuvaev, Andrey N., Fritsler, Yana V., Khilazheva, Elena D., Mosyagina, Angelina I., Hirai, Hirokazu, Teschemacher, Anja G., Kasparov, Sergey

“…Spinocerebellar ataxia type 1 (SCA1) is an intractable progressive neurodegenerative disease that leads to a range of movement and motor defects and is…”
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Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice by Shuvaev, Anton N., Hosoi, Nobutake, Sato, Yamato, Yanagihara, Dai, Hirai, Hirokazu

“…Key points Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disease caused by a gene defect, leading to movement disorder such as…”
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Memantine Disrupts Motor Coordination through Anxiety-like Behavior in CD1 Mice by Shuvaev, Anton N, Belozor, Olga S, Mozhei, Oleg I, Mileiko, Aleksandra G, Mosina, Ludmila D, Laletina, Irina V, Mikhailov, Ilia G, Fritsler, Yana V, Shuvaev, Andrey N, Teschemacher, Anja G, Kasparov, Sergey

“…Memantine is an FDA approved drug for the treatment of Alzheimer's disease. It reduces neurodegeneration in the hippocampus and cerebral cortex through the…”
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Current advances in cell electrophysiology: applications for the analysis of intercellular communications within the neurovascular unit by Shuvaev, Anton N, Salmin, Vladimir V, Kuvacheva, Natalia V, Pozhilenkova, Elena A, Morgun, Andrey V, Lopatina, Olga L, Salmina, Alla B, Illarioshkin, Sergey N

“…Patch clamp is a golden standard for studying (patho)physiological processes affecting membranes of excitable cells. This method is rather labor-intensive and…”
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Extracellular S100β Disrupts Bergman Glia Morphology and Synaptic Transmission in Cerebellar Purkinje Cells by Belozor, Olga S, Yakovleva, Dariya A, Potapenko, Ilya V, Shuvaev, Andrey N, Smolnikova, Marina V, Vasilev, Alex, Pozhilenkova, Elena A, Shuvaev, Anton N

“…Astrogliosis is a pathological process that affects the density, morphology, and function of astrocytes. It is a common feature of brain trauma, autoimmune…”
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Buckwheat-enriched diet alleviates bisphenol A mediated oxidative stress via modulation of sirtuin 1 and antioxidant status in experimental rats by Pande, Shubhra, Ranjan, Rajeev, Ryazanova, Maria, Shuvaev, Anton N., Salmina, Alla B., Kratasyuk, Valentina A.

“…•Dietary buckwheat countered bisphenol-A (BPA) induced oxidative stress in rats.•Buckwheat enhanced sirtuin1 levels without affecting body weight.•BPA did not…”
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Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo by Shuvaev, Anton N, Horiuchi, Hajime, Seki, Takahiro, Goenawan, Hanna, Irie, Tomohiko, Iizuka, Akira, Sakai, Norio, Hirai, Hirokazu

“…Cerebellar Purkinje cells (PCs) express a large amount of the γ isoform of protein kinase C (PKCγ) and a modest level of PKCα. The PKCγ is involved in the…”
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NLRP3 deficiency-induced hippocampal dysfunction and anxiety-like behavior in mice by Komleva, Yulia K., Lopatina, Olga L., Gorina, Iana V., Shuvaev, Anton N., Chernykh, Anatoly, Potapenko, Ilia V., Salmina, Alla B.

“…•Deletion of NLRP3 inflammasome cause anxiety-like behavior in mice.•NLRP3 knockout mice exhibit abnormal behavior in the fear-conditioning test.•The adult…”
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Mesenchymal Stem Cells Ameliorate Cerebellar Pathology in a Mouse Model of Spinocerebellar Ataxia Type 1 by Matsuura, Serina, Shuvaev, Anton N., Iizuka, Akira, Nakamura, Kazuhiro, Hirai, Hirokazu

“…Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disorder caused by the expansion of a polyglutamine tract in the ataxin-1 protein. To…”
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Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells by Konno, Ayumu, Shuvaev, Anton N., Miyake, Noriko, Miyake, Koichi, Iizuka, Akira, Matsuura, Serina, Huda, Fathul, Nakamura, Kazuhiro, Yanagi, Shigeru, Shimada, Takashi, Hirai, Hirokazu

“…Spinocerebellar ataxia type 3 (SCA3) is caused by the abnormal expansion of CAG repeats within the ataxin-3 gene. Previously, we generated transgenic mice…”
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Blood–Brain Barrier Breakdown in Stress and Neurodegeneration: Biochemical Mechanisms and New Models for Translational Research by Salmina, Alla B., Komleva, Yuliya K., Malinovskaya, Nataliya A., Morgun, Andrey V., Teplyashina, Elena A., Lopatina, Olga L., Gorina, Yana V., Kharitonova, Ekaterina V., Khilazheva, Elena D., Shuvaev, Anton N.

“…Blood-brain barrier (BBB) is a structural and functional element of the neurovascular unit (NVU), which includes cells of neuronal, glial, and endothelial…”
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Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein by Takahashi, Hideyuki, Adachi, Naoko, Shirafuji, Toshihiko, Danno, Sally, Ueyama, Takehiko, Vendruscolo, Michele, Shuvaev, Anton N, Sugimoto, Takuya, Seki, Takahiro, Hamada, Daizo, Irie, Kazuhiro, Hirai, Hirokazu, Sakai, Norio, Saito, Naoaki

“…Amyloid assemblies are associated with a wide range of human disorders, including Alzheimer's and Parkinson's diseases. Here, we identify protein kinase C…”
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