Search Results - "Shuvaev, Andrey N"

Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1 by Shuvaev, Anton N., Belozor, Olga S., Mozhei, Oleg, Yakovleva, Dariya A., Potapenko, Ilya V., Shuvaev, Andrey N., Smolnikova, Marina V., Salmin, Vladimir V., Salmina, Alla B., Hirai, Hirokazu, Teschemacher, Anja G., Kasparov, Sergey

“…Bergmann glia (BG) are highly specialized radial astrocytes of the cerebellar cortex, which play a key role in the uptake of synaptic glutamate via the…”
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Protective Effect of Memantine on Bergmann Glia and Purkinje Cells Morphology in Optogenetic Model of Neurodegeneration in Mice by Shuvaev, Anton N., Belozor, Olga S., Mozhei, Oleg I., Khilazheva, Elena D., Shuvaev, Andrey N., Fritsler, Yana V., Kasparov, S.

“…Spinocerebellar ataxias are a family of fatal inherited diseases affecting the brain. Although specific mutated proteins are different, they may have a common…”
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Memantine suppresses the excitotoxicity but fails to rescue the ataxic phenotype in SCA1 model mice by Belozor, Olga S., Vasilev, Alex, Mileiko, Alexandra G., Mosina, Lyudmila D., Mikhailov, Ilya G., Ox, Darius A., Boitsova, Elizaveta B., Shuvaev, Andrey N., Teschemacher, Anja G., Kasparov, Sergey, Shuvaev, Anton N.

“…Spinocerebellar ataxia type 1 (SCA1) is a debilitating neurodegenerative disorder of the cerebellum and brainstem. Memantine has been proposed as a potential…”
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Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1 by Shuvaev, Anton N., Belozor, Olga S., Mozhei, Oleg I., Shuvaev, Andrey N., Fritsler, Yana V., Khilazheva, Elena D., Mosyagina, Angelina I., Hirai, Hirokazu, Teschemacher, Anja G., Kasparov, Sergey

“…Spinocerebellar ataxia type 1 (SCA1) is an intractable progressive neurodegenerative disease that leads to a range of movement and motor defects and is…”
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Memantine Disrupts Motor Coordination through Anxiety-like Behavior in CD1 Mice by Shuvaev, Anton N, Belozor, Olga S, Mozhei, Oleg I, Mileiko, Aleksandra G, Mosina, Ludmila D, Laletina, Irina V, Mikhailov, Ilia G, Fritsler, Yana V, Shuvaev, Andrey N, Teschemacher, Anja G, Kasparov, Sergey

“…Memantine is an FDA approved drug for the treatment of Alzheimer's disease. It reduces neurodegeneration in the hippocampus and cerebral cortex through the…”
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Extracellular S100β Disrupts Bergman Glia Morphology and Synaptic Transmission in Cerebellar Purkinje Cells by Belozor, Olga S, Yakovleva, Dariya A, Potapenko, Ilya V, Shuvaev, Andrey N, Smolnikova, Marina V, Vasilev, Alex, Pozhilenkova, Elena A, Shuvaev, Anton N

“…Astrogliosis is a pathological process that affects the density, morphology, and function of astrocytes. It is a common feature of brain trauma, autoimmune…”
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NMDA receptor antagonists as potential therapy in cerebellar degenerative disorders by Belozor, Olga S., Shuvaev, Andrey N., Fritsler, Yana V., Shuvaev, Anton N.

“…Cerebellar degeneration remains a poorly studied topic. Excitotoxicity, i.e. neuronal damage and death due to excess activation of postsynaptic…”
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3,5-Dimethyladamantan-1-amine Restores Short-term Synaptic Plasticity by Changing Function of Excitatory Amino Acid Transporters in Mouse Model of Spinocerebellar Ataxia Type 1 by Belozor, Olga S., Vasilev, Alex A., Mileiko, Alexandra G., Mosina, Liudmila D., Mikhailov, Ilya G., Shuvaev, Andrey N., Shuvaev, Anton N.

“…Introduction. Memantine is an agent that used for treatment of Alzheimer's type dementia. Memantine considerably reduces the effects of neurodegeneration, may…”
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The effect of reactive Bergmann glia on short-term synaptic plasticity in cerebellar neurodegenerative models, caused by chronic activation of ChR2 and expression of the mutant ataxin-1 by Аnton N. Shuvaev, Оlga S. Belozor, Oleg I. Mozjei, Daria A. Yakovleva, Аndrey N. Shuvaev, Marina V. Smolnikova, Еlena A. Pozhilenkova, S. . Каsparov, Vladimir V. Salmin, Аlla B. Salmina

“…Introduction. Synaptic plasticity is impaired in the early stages of a neurodegenerative process but is potentially reversible. The study of mechanisms…”
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