Search Results - "Shuttleworth, Lindsay K"

Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3K δ by Allen, Rodger A, Brookings, Daniel C, Powell, Mark J, Delgado, Jean, Shuttleworth, Lindsay K, Merriman, Mark, Fahy, Ian J, Tewari, Roohi, Silva, John P, Healy, Louise J, Davies, Gareth C G, Twomey, Breda, Cutler, Rona M, Kotian, Apoorva, Crosby, Andrea, McCluskey, Gillian, Watt, Gillian F, Payne, Andrew

“…Phosphoinositide 3-kinases (PI3K) are key signaling enzymes regulating cellular survival, development, and function. Expression of the PI3K isoform is largely…”
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Human immunoglobulin E flexes between acutely bent and extended conformations by Drinkwater, Nyssa, Cossins, Benjamin P, Keeble, Anthony H, Wright, Michael, Cain, Katharine, Hailu, Hanna, Oxbrow, Amanda, Delgado, Jean, Shuttleworth, Lindsay K, Kao, Michael W-P, McDonnell, James M, Beavil, Andrew J, Henry, Alistair J, Sutton, Brian J

“…IgE molecules associate with the FcɛRIα receptor in an acutely bent conformation where the Cɛ2 domains fold over the Cɛ3-Cɛ4 domains. A new study demonstrates…”
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