Search Results - "Shuttleworth, J"

Orai3 – the ‘exceptional’ Orai? by Shuttleworth, Trevor J.

“…The field of agonist‐activated Ca2+ entry in non‐excitable cells underwent a revolution some 5 years ago with the discovery of the Orai proteins as the…”
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OMFS: My favourite instrument by Shuttleworth, J.

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COSMOS: the COsmic-ray Soil Moisture Observing System by Zreda, M, Shuttleworth, W. J, Zeng, X, Zweck, C, Desilets, D, Franz, T, Rosolem, R

“…The newly-developed cosmic-ray method for measuring area-average soil moisture at the hectometer horizontal scale is being implemented in the COsmic-ray Soil…”
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Exploring the specificity of the PI3K family inhibitor LY294002 by Gharbi, Severine I, Zvelebil, Marketa J, Shuttleworth, Stephen J, Hancox, Tim, Saghir, Nahid, Timms, John F, Waterfield, Michael D

“…The PI3Ks (phosphatidylinositol 3-kinases) regulate cellular signalling networks that are involved in processes linked to the survival, growth, proliferation,…”
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Arachidonic acid, ARC channels, and Orai proteins by Shuttleworth, Trevor J

“…Abstract A critical role for arachidonic acid in the regulation of calcium entry during agonist activation of calcium signals has become increasingly apparent…”
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The COsmic-ray Soil Moisture Interaction Code (COSMIC) for use in data assimilation by Shuttleworth, J, Rosolem, R, Zreda, M, Franz, T

“…Soil moisture status in land surface models (LSMs) can be updated by assimilating cosmic-ray neutron intensity measured in air above the surface. This requires…”
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Orai1 subunit stoichiometry of the mammalian CRAC channel pore by Mignen, Olivier, Thompson, Jill L., Shuttleworth, Trevor J.

“…Agonist-activated Ca 2+ entry plays a critical role in Ca 2+ signalling in non-excitable cells. One mode of such entry is activated as a consequence of the…”
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STIM and Orai proteins and the non-capacitative ARC channels by Shuttleworth, Trevor J

“…The ARC channel is a small conductance, highly Ca²⁺-selective ion channel whose activation is specifically dependent on low concentrations of arachidonic acid…”
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Predictive factors of hospital stay in patients with odontogenic maxillofacial infections: the role of C-reactive protein by Stathopoulos, P, Igoumenakis, D, Shuttleworth, J, Smith, W, Ameerally, P

“…Abstract To investigate whether clinical or laboratory variables on admission of patients with odontogenic infections are associated with a severe clinical…”
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Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors by Shuttleworth, S J, Silva, F A, Cecil, A R L, Tomassi, C D, Hill, T J, Raynaud, F I, Clarke, P A, Workman, P

“…The phosphoinositide 3-kinases (PI3Ks) constitute an important family of lipid kinase enzymes that control a range of cellular processes through their…”
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Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels by Mignen, Olivier, Thompson, Jill L., Shuttleworth, Trevor J.

“…Agonist-activated Ca 2+ signals in non-excitable cells are profoundly influenced by calcium entry via both store-operated and store-independent conductances…”
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The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits by Mignen, Olivier, Thompson, Jill L., Shuttleworth, Trevor J.

“…The activation of Ca 2+ entry is a critical component of agonist-induced cytosolic Ca 2+ signals in non-excitable cells. Although a variety of different…”
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STIM1 regulates Ca2+ entry via arachidonate-regulated Ca2+-selective (ARC) channels without store depletion or translocation to the plasma membrane by Mignen, Olivier, Thompson, Jill L., Shuttleworth, Trevor J.

“…Recent studies have indicated a critical role for STIM (stromal interacting molecule) proteins in the regulation of the store-operated mode of…”
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Translating aboveground cosmic-ray neutron intensity to high-frequency soil moisture profiles at sub-kilometer scale by Rosolem, R, Hoar, T, Arellano, A, Anderson, J. L, Shuttleworth, W. J, Zeng, X, Franz, T. E

“…Above-ground cosmic-ray neutron measurements provide an opportunity to infer soil moisture at the sub-kilometer scale. Initial efforts to assimilate those…”
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NHS dentistry: The social media challenge by Shuttleworth, J., Smith, W.

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Selective activation of distinct Orai channels by STIM1 by Shuttleworth, Trevor J

“…Graphical abstract…”
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Comment on "Technical Note: On the Matt–Shuttleworth approach to estimate crop water requirements" by Lhomme et al. (2014) by Shuttleworth, W. J

“…It is clear from Lhomme et al. (2014) that aspects of the explanation of the Matt–Shuttleworth approach can generate confusion. Presumably this is because the…”
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Characterization, Cryopreservation, and Ablation of Spermatogonial Stem Cells in Adult Rhesus Macaques by Hermann, Brian P., Sukhwani, Meena, Lin, Chih‐Cheng, Sheng, Yi, Tomko, Jamie, Rodriguez, Mario, Shuttleworth, Jennifer J., McFarland, David, Hobbs, Robin M., Pandolfi, Pier Paolo, Schatten, Gerald P., Orwig, Kyle E.

“…Spermatogonial stem cells (SSCs) are at the foundation of mammalian spermatogenesis. Whereas rare Asingle spermatogonia comprise the rodent SSC pool, primate…”
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Creation of the WATCH Forcing Data and Its Use to Assess Global and Regional Reference Crop Evaporation over Land during the Twentieth Century by Weedon, G. P., Gomes, S., Viterbo, P., Shuttleworth, W. J., Blyth, E., Österle, H., Adam, J. C., Bellouin, N., Boucher, O., Best, M.

“…The Water and Global Change (WATCH) project evaluation of the terrestrial water cycle involves using land surface models and general hydrological models to…”
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I ARC, a Novel Arachidonate-regulated, Noncapacitative Ca2+ Entry Channel by Mignen, Olivier, Shuttleworth, Trevor J.

“…Along with the inositol trisphosphate-induced release of stored Ca 2+ , a receptor-enhanced entry of Ca 2+ is a critical component of intracellular Ca 2+…”
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