Search Results - "Shuttleworth, C. William"

Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial by Carlson, Andrew P, Abbas, Mohammad, Alunday, Robert L, Qeadan, Fares, Shuttleworth, C William

“…Retrospective clinical data and case studies support a therapeutic effect of ketamine in suppression of spreading depolarization (SD) following brain injury…”
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Zinc: new clues to diverse roles in brain ischemia by Shuttleworth, C. William, Weiss, John H

“…Cerebral ischemia is a leading cause of morbidity and mortality, reflecting the extraordinary sensitivity of the brain to a brief loss of blood flow. A…”
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Spreading depolarization may represent a novel mechanism for delayed fluctuating neurological deficit after chronic subdural hematoma evacuation by Mohammad, Laila M, Abbas, Mohammad, Shuttleworth, C William, Ahmadian, Rosstin, Bhat, Annapoorna, Hill, Deirdre A, Carlson, Andrew P

“…Most patients with chronic subdural hematoma (cSDH) recover after surgical evacuation with a straightforward course. There is a subset of patients who develop…”
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Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons by Aiba, Isamu, Shuttleworth, C. William

“…Key points •  Spreading depolarization (SD) is a profound neuronal and glial depolarization implicated in the progression of acute brain injury. •  In…”
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Action Potentials Are Critical for the Propagation of Focally Elicited Spreading Depolarizations by Suryavanshi, Pratyush, Reinhart, Katelyn M, Shuttleworth, C William, Brennan, K C

“…Spreading depolarizations (SDs) of gray matter occur in the brain in different pathologic conditions, and cause varying degrees of tissue damage depending on…”
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Neural stem/progenitor cells display a low requirement for oxidative metabolism independent of hypoxia inducible factor‐1alpha expression by Candelario, Kate M., Shuttleworth, C. William, Cunningham, Lee Anna

“…Neural stem/progenitor cells (NSPCs) are multipotent cells within the embryonic and adult brain that give rise to both neuronal and glial cell lineages…”
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Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury? by Seidel, Jessica L., Escartin, Carole, Ayata, Cenk, Bonvento, Gilles, Shuttleworth, C. William

“…Spreading depolarizations (SDs) are coordinated waves of synchronous depolarization, involving large numbers of neurons and astrocytes as they spread slowly…”
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Synaptic Zn2+ contributes to deleterious consequences of spreading depolarizations by Bennett, Michael C., Reinhart, Katelyn M., Weisend, Jordan E., Morton, Russell A., Carlson, Andrew P., Shuttleworth, C. William

“…Spreading depolarizations (SDs) are profound waves of neuroglial depolarization that can propagate repetitively through injured brain. Recent clinical work has…”
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Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation by Shuttleworth, C. William

“…Synaptic stimulation in brain slices is accompanied by changes in tissue autofluorescence, which are a consequence of changes in tissue metabolism…”
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Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations by Hartings, Jed A, Li, Chunyan, Hinzman, Jason M, Shuttleworth, C William, Ernst, Griffin L, Dreier, Jens P, Wilson, J Adam, Andaluz, Norberto, Foreman, Brandon, Carlson, Andrew P

“…Spreading depolarizations cause cortical electrical potential changes over a wide spectral range that includes slow potentials approaching the direct current…”
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Characterization of inhibitory GABA-A receptor activation during spreading depolarization in brain slice by Aiba, Isamu, Shuttleworth, C William

“…Spreading depolarization (SD) is a slowly propagating wave of near complete depolarizations of neurons and glia. Previous studies have reported large GABA…”
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Effect of Locally Delivered Nimodipine Microparticles on Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage by Carlson, Andrew P., Alchbli, Amal, Hänggi, Daniel, Macdonald, R. Loch, Shuttleworth, C. William

“…Background Recurrent spreading depolarizations (SDs) occur in patients after aneurysmal subarachnoid hemorrhage (aSAH), resulting in metabolic stress to brain…”
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Intracellular Zn2+ Accumulation Contributes to Synaptic Failure, Mitochondrial Depolarization, and Cell Death in an Acute Slice Oxygen-Glucose Deprivation Model of Ischemia by Medvedeva, Yuliya V, Lin, Bin, Shuttleworth, C. William, Weiss, John H

“…Despite considerable evidence for contributions of both Zn(2+) and Ca(2+) in ischemic brain damage, the relative importance of each cation to very early events…”
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Cortical spreading depression occurs during elective neurosurgical procedures by Carlson, Andrew P, Shuttleworth, C William, Mead, Brittany, Burlbaw, Brittany, Krasberg, Mark, Yonas, Howard

“…OBJECTIVE Cortical spreading depression (CSD) has been observed with relatively high frequency in the period following human brain injury, including traumatic…”
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Repetitive spreading depolarization induces gene expression changes related to synaptic plasticity and neuroprotective pathways by Dell'Orco, Michela, Weisend, Jordan E, Perrone-Bizzozero, Nora I, Carlson, Andrew P, Morton, Russell A, Linsenbardt, David N, Shuttleworth, C William

“…Spreading depolarization (SD) is a slowly propagating wave of profound depolarization that sweeps through cortical tissue. While much emphasis has been placed…”
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What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient? by Helbok, Raimund, Hartings, Jed A., Schiefecker, Alois, Balança, Baptiste, Jewel, Sharon, Foreman, Brandon, Ercole, Ari, Balu, Ramani, Ayata, Cenk, Ngwenya, Laura, Rosenthal, Eric, Boutelle, Martyn G., Farkas, Eszter, Dreier, Jens P., Fabricius, Martin, Shuttleworth, C. William, Carlson, Andrew

“…The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the…”
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Which Spreading Depolarizations Are Deleterious To Brain Tissue? by Shuttleworth, C. William, Andrew, R. David, Akbari, Yama, Ayata, Cenk, Balu, Ramani, Brennan, K. C., Boutelle, Martyn, Carlson, Andrew P., Dreier, Jens P., Fabricius, Martin, Farkas, Eszter, Foreman, Brandon, Helbok, Raimund, Henninger, Nils, Jewell, Sharon L., Jones, Stephen C., Kirov, Sergei A., Lindquist, Britta E., Maciel, Carolina B., Okonkwo, David, Reinhart, Katelyn M., Robertson, R. Meldrum, Rosenthal, Eric S., Watanabe, Tomas, Hartings, Jed A.

“…Spreading depolarizations (SDs) are profound disruptions of cellular homeostasis that slowly propagate through gray matter and present an extraordinary…”
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Transcranial direct current stimulation modulates working memory and prefrontal-insula connectivity after mild-moderate traumatic brain injury by Quinn, Davin K, Story-Remer, Jacqueline, Brandt, Emma, Fratzke, Violet, Rieger, Rebecca, Wilson, John Kevin, Gill, Darbi, Mertens, Nickolas, Hunter, Michael, Upston, Joel, Jones, Thomas R, Richardson, Jessica D, Myers, Orrin, Arciniegas, David B, Campbell, Richard, Clark, Vincent P, Yeo, Ronald A, Shuttleworth, C William, Mayer, Andrew R

“…Persistent posttraumatic symptoms (PPS) may manifest after a mild-moderate traumatic brain injury (mmTBI) even when standard brain imaging appears normal…”
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Hypoxia limits inhibitory effects of Zn2+ on spreading depolarizations by Aiba, Isamu, Shuttleworth, C William

“…Spreading depolarizations (SDs) are coordinated depolarizations of brain tissue that have been well-characterized in animal models and more recently implicated…”
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Brain Tsunamis in Human High-Grade Glioma: Preliminary Observations by Colpitts, Kayli, Desai, Masoom J, Kogan, Michael, Shuttleworth, C William, Carlson, Andrew P

“…Gliomas make up nearly 40% of all central nervous system tumors, with over 50% of those being high-grade gliomas. Emerging data suggests that…”
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