Search Results - "Shuttleworth, C. C."

Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial by Carlson, Andrew P, Abbas, Mohammad, Alunday, Robert L, Qeadan, Fares, Shuttleworth, C William

“…Retrospective clinical data and case studies support a therapeutic effect of ketamine in suppression of spreading depolarization (SD) following brain injury…”
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Zinc: new clues to diverse roles in brain ischemia by Shuttleworth, C. William, Weiss, John H

“…Cerebral ischemia is a leading cause of morbidity and mortality, reflecting the extraordinary sensitivity of the brain to a brief loss of blood flow. A…”
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Ketamine reduces deleterious consequences of spreading depolarizations by Reinhart, Katelyn M., Shuttleworth, C. William

“…Recent work has implicated spreading depolarization (SD) as a key contributor the progression of acute brain injuries, however development of interventions…”
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Spreading depolarization may represent a novel mechanism for delayed fluctuating neurological deficit after chronic subdural hematoma evacuation by Mohammad, Laila M, Abbas, Mohammad, Shuttleworth, C William, Ahmadian, Rosstin, Bhat, Annapoorna, Hill, Deirdre A, Carlson, Andrew P

“…Most patients with chronic subdural hematoma (cSDH) recover after surgical evacuation with a straightforward course. There is a subset of patients who develop…”
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Action Potentials Are Critical for the Propagation of Focally Elicited Spreading Depolarizations by Suryavanshi, Pratyush, Reinhart, Katelyn M, Shuttleworth, C William, Brennan, K C

“…Spreading depolarizations (SDs) of gray matter occur in the brain in different pathologic conditions, and cause varying degrees of tissue damage depending on…”
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Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons by Aiba, Isamu, Shuttleworth, C. William

“…Key points •  Spreading depolarization (SD) is a profound neuronal and glial depolarization implicated in the progression of acute brain injury. •  In…”
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Spreading Depolarization Induces a Transient Potentiation of Excitatory Synaptic Transmission by Weisend, Jordan E., Carlson, Andrew P., Shuttleworth, C. William

“…•Synaptic potentiation after spreading depolarization is robust in CA1 hippocampus.•Saturated after single SD and resolved after ∼3 h.•Not confounded by…”
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Editorial. What causes excitotoxicity after concussion? by Carlson, Andrew P, Shuttleworth, C William

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Adenovirus remains widespread in squirrels on Anglesey by Shuttleworth, CM, Everest, DJ, McQueen, A

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Characterization of inhibitory GABA-A receptor activation during spreading depolarization in brain slice by Aiba, Isamu, Shuttleworth, C William

“…Spreading depolarization (SD) is a slowly propagating wave of near complete depolarizations of neurons and glia. Previous studies have reported large GABA…”
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Evidence that adenosine contributes to Leao’s spreading depression in vivo by Lindquist, Britta E, Shuttleworth, C William

“…Leao’s spreading depression of cortical activity is a propagating silencing of neuronal activity resulting from spreading depolarization (SD). We evaluated the…”
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Neural stem/progenitor cells display a low requirement for oxidative metabolism independent of hypoxia inducible factor‐1alpha expression by Candelario, Kate M., Shuttleworth, C. William, Cunningham, Lee Anna

“…Neural stem/progenitor cells (NSPCs) are multipotent cells within the embryonic and adult brain that give rise to both neuronal and glial cell lineages…”
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Cerebral Autoregulation Correlation With Outcomes and Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage by Owen, Bryce, Vangala, Adarsh, Fritch, Chanju, Alsarah, Ali A., Jones, Tom, Davis, Herbert, Shuttleworth, C. William, Carlson, Andrew P.

“…Delayed cerebral ischemia remains one of the principal therapeutic targets after aneurysmal subarachnoid hemorrhage. While large vessel vasospasm may…”
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Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices by Lindquist, B.E, Shuttleworth, C.W

“…Highlights ► We examined suppression of synaptic potentials following spreading depolarization (SD). ► Initial inhibition was explained by a short period of…”
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Vascular endothelial growth factor can signal through platelet-derived growth factor receptors by Ball, Stephen G, Shuttleworth, C. Adrian, Kielty, Cay M

“…Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow-derived human adult…”
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Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group by Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren KL, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, KC, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew IR, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn MJM, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, Hartings, Jed A

“…Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic…”
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Terminal spreading depolarizations causing electrocortical silencing prior to clinical brain death: case report by Carlson, Andrew P, Shuttleworth, C William, Major, Sebastian, Lemale, Coline L, Dreier, Jens P, Hartings, Jed A

“…The authors report on a 57-year-old woman in whom progression to brain death occurred on day 9 after aneurysmal subarachnoid hemorrhage without evidence of…”
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Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury? by Seidel, Jessica L., Escartin, Carole, Ayata, Cenk, Bonvento, Gilles, Shuttleworth, C. William

“…Spreading depolarizations (SDs) are coordinated waves of synchronous depolarization, involving large numbers of neurons and astrocytes as they spread slowly…”
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Ketamine improves neuronal recovery following spreading depolarization in peri‐infarct tissues by Reinhart, Katelyn M., Morton, Russell A., Brennan, K. C., Carlson, Andrew P., Shuttleworth, C. William

“…Spreading depolarization (SD) has emerged as an important contributor to the enlargement of acute brain injuries. We previously showed that the…”
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The Ruptured Aneurysm Patient's Disability Correlation with Autoregulatory Measures, Spreading Depolarization, and Vasospasm by Fritch, Chanju, Owen, Bryce, Shuttleworth, C. William, Carlson, Andrew P

“…INTRODUCTION Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease associated with disability following patient's hospital course. Traditionally,…”
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