Search Results - "Shuster, Diana"

Framework for the Design of Cannabis-Mediated Phase I Drug-Drug Interaction Studies by Shuster, Diana L, Pastino, Gina, Cerneus, Dirk

“…Cannabis has become legal in much of the United States similar to many other countries, for either recreational or medical use. The use of cannabis products is…”
Get more information

Clinical Pharmacokinetics of Ombitasvir by Badri, Prajakta S., Shuster, Diana L., Dutta, Sandeep, Menon, Rajeev M.

“…Ombitasvir is a potent, nonstructural protein 5A inhibitor of the hepatitis C virus (HCV) that is used in combination with other direct-acting antivirals for…”
Get full text

Drug–Drug Interactions Between the Anti-Hepatitis C Virus 3D Regimen of Ombitasvir, Paritaprevir/Ritonavir, and Dasabuvir and Eight Commonly Used Medications in Healthy Volunteers by Polepally, Akshanth R., King, Jennifer R., Ding, Bifeng, Shuster, Diana L., Dumas, Emily O., Khatri, Amit, Chiu, Yi-Lin, Podsadecki, Thomas J., Menon, Rajeev M.

“…Background and Aims The three direct-acting antiviral regimen of ombitasvir/paritaprevir/ritonavir and dasabuvir (3D regimen) is approved for treatment of…”
Get full text

Variability in Expression of CYP3A5 in Human Fetal Liver by Vyhlidal, Carrie A, Pearce, Robin E, Gaedigk, Roger, Calamia, Justina C, Shuster, Diana L, Thummel, Kenneth E, Leeder, J Steven

“…Members of the cytochrome P450 3A (CYP3A) subfamily of drug metabolizing enzymes exhibit developmental changes in expression in human liver characterized by a…”
Get full text

Identification of CYP3A7 for glyburide metabolism in human fetal livers by Shuster, Diana L., Risler, Linda J., Prasad, Bhagwat, Calamia, Justina C., Voellinger, Jenna L., Kelly, Edward J., Unadkat, Jashvant D., Hebert, Mary F., Shen, Danny D., Thummel, Kenneth E., Mao, Qingcheng

“…Glyburide is commonly prescribed for the treatment of gestational diabetes mellitus; however, fetal exposure to glyburide is not well understood and may have…”
Get full text

Effects of chronic kidney disease stage 4, end-stage renal disease, or dialysis on the plasma concentrations of ombitasvir, paritaprevir, ritonavir, and dasabuvir in patients with chronic HCV infection: pharmacokinetic analysis of the phase 3 RUBY-I and RUBY-II trials by Shuster, Diana L., Menon, Rajeev M., Ding, Bifeng, Khatri, Amit, Li, Hong, Cohen, Eric, Jewett, Melissa, Cohen, Daniel E., Zha, Jiuhong

“…Purpose To characterize the pharmacokinetics of ombitasvir, paritaprevir, ritonavir, dasabuvir, and ribavirin in hepatitis C virus (HCV)-infected patients with…”
Get full text

Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus by Shuster, Diana L., Shireman, Laura M., Ma, Xiaosu, Shen, Danny D., Flood Nichols, Shannon K., Ahmed, Mahmoud S., Clark, Shannon, Caritis, Steve, Venkataramanan, Raman, Haas, David M., Quinney, Sara K., Haneline, Laura S., Tita, Alan T., Manuck, Tracy A., Thummel, Kenneth E., Brown, Linda Morris, Ren, Zhaoxia, Brown, Zane, Easterling, Thomas R., Hebert, Mary F.

“…In gestational diabetes mellitus (GDM), women are unable to compensate for the increased insulin resistance during pregnancy. Data are limited regarding the…”
Get full text

Identification of Proline Residues in or near the Transmembrane Helices of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) That Are Important for Transport Activity and Substrate Specificity by Ni, Zhanglin, Bikadi, Zsolt, Shuster, Diana L, Zhao, Chunsheng, Rosenberg, Mark F, Mao, Qingcheng

“…The human breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance and mediates the active efflux of drugs and xenobiotics. BCRP contains one…”
Get full text

Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus by Shuster, Diana L., Shireman, Laura M., Ma, Xiaosu, Shen, Danny D., Flood Nichols, Shannon K., Ahmed, Mahmoud S., Clark, Shannon, Caritis, Steve, Venkataramanan, Raman, Haas, David M., Quinney, Sara K., Haneline, Laura S., Tita, Alan T., Manuck, Tracy A., Thummel, Kenneth E., Morris Brown, Linda, Ren, Zhaoxia, Brown, Zane, Easterling, Thomas R., Hebert, Mary F.

“…Gestational diabetes mellitus is a condition similar to type 2 diabetes mellitus (T2DM) in that patients are unable to compensate for the degree of insulin…”
Get full text

Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice by Shuster, Diana L, Bammler, Theo K, Beyer, Richard P, Macdonald, James W, Tsai, Jesse M, Farin, Frederico M, Hebert, Mary F, Thummel, Kenneth E, Mao, Qingcheng

“…Pregnancy-induced changes in drug pharmacokinetics can be explained by changes in expression of drug-metabolizing enzymes and transporters and/or normal…”
Get full text

Clinical pharmacology and tolerability of REC‐994, a redox‐cycling nitroxide compound, in randomized phase 1 dose‐finding studies by Alfa, Ron, Considine, Timothy, Virani, Shafique, Pfeiffer, Matt, Donato, Anthony, Dickerson, Daniel, Shuster, Diana, Ellis, Joel, Rushton, Kristen, Wei, Helen, Gibson, Christopher

“…Cerebral cavernous malformation (CCM) has variable clinical symptoms, including potentially fatal hemorrhagic stroke. Treatment options are very limited,…”
Get full text

Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation by Tatipalli, Manasa, Siripuram, Vijay Kumar, Long, Tao, Shuster, Diana, Bernstein, Galina, Martineau, Pierre, Cook, Kim A., Cristofoletti, Rodrigo, Schmidt, Stephan, Vozmediano, Valvanera

“…Quantitative pharmacology brings important advantages in the design and conduct of pediatric clinical trials. Herein, we demonstrate the application of a…”
Get full text

Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age by Shuster, Diana L, Risler, Linda J, Liang, Chao-Kang J, Rice, Kenneth M, Shen, Danny D, Hebert, Mary F, Thummel, Kenneth E, Mao, Qingcheng

“…Gestational diabetes mellitus is a major complication of human pregnancy. The oral clearance (CL) of glyburide, an oral antidiabetic drug, increases 2-fold in…”
Get more information

Ombitasvir/Paritaprevir/Ritonavir With or Without Dasabuvir and With or Without Ribavirin for Adolescents With HCV Genotype 1 or 4 by Leung, Daniel H., Wirth, Stefan, Yao, Betty B., Viani, Rolando M., Gonzalez‐Peralta, Regino P., Jonas, Maureen M., Lobritto, Steven J., Narkewicz, Michael R., Sokal, Etienne, Fortuny, Clàudia, Hsu, Evelyn K., Del Valle‐Segarra, Antonio, Zha, Jiuhong, Larsen, Lois, Liu, Li, Shuster, Diana L., Cohen, Daniel E., Rosenthal, Philip

“…In adults, treatment of hepatitis C virus (HCV) infection with ombitasvir (OBV)/paritaprevir (PTV)/ritonavir (r) with or without dasabuvir (DSV) and ±ribavirin…”
Get full text

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir With or Without Ribavirin in Patients With Kidney Disease by Bernstein, David E, Tran, Albert, Martin, Paul, Kowdley, Kris V, Bourliere, Marc, Sulkowski, Mark S, Pockros, Paul J, Renjifo, Boris, Wang, Deli, Shuster, Diana L, Cohen, Daniel E, Jacobson, Ira M

“…Patients with hepatitis C virus (HCV) infection and chronic kidney disease (CKD) are a high-priority population for treatment. We performed a pooled efficacy…”
Get full text

Gestational Age-Dependent Changes in Gene Expression of Metabolic Enzymes and Transporters in Pregnant Mice by Shuster, Diana L., Bammler, Theo K., Beyer, Richard P., MacDonald, James W., Tsai, Jesse M., Farin, Frederico M., Hebert, Mary F., Thummel, Kenneth E., Mao, Qingcheng

Get full text

Efflux transporters in drug disposition during pregnancy by Chen, Xin, Gao, Chunying, Han, Lyrialle W, Heidelberger, Sibylle, Liao, Michael Z, Neradugomma, Naveen K, Ni, Zhanglin, Shuster, Diana L, Wang, Honggang, Zhang, Yi, Zhou, Lin

“…Evidence-based dose selection of drugs in pregnant women has been lacking due to challenges in studying maternal-fetal pharmacokinetics. Hence, many drugs are…”
Get full text

Pharmacodynamics of metformin in pregnant women with gestational diabetes mellitus and non-pregnant women with type 2 diabetes mellitus by Shuster, Diana L., Shireman, Laura M., Ma, Xiaosu, Shen, Danny D., Flood Nichols, Shannon K., Ahmed, Mahmoud S., Clark, Shannon, Caritis, Steve, Venkataramanan, Raman, Haas, David M., Quinney, Sara K., Haneline, Laura S., Tita, Alan T., Manuck, Tracy A., Thummel, Kenneth E., Brown, Linda Morris, Ren, Zhaoxia, Brown, Zane, Easterling, Thomas R., Hebert, Mary F.

“…Gestational diabetes mellitus is a condition similar to type 2 diabetes mellitus (T2DM) in that patients are unable to compensate for the degree of insulin…”
Get full text

Gestational age‐dependent maternal‐fetal glyburide disposition in pregnant mice (1141.5) by Shuster, Diana, Risler, Linda, Liang, Jason, Rice, Kenneth, Shen, Danny, Hebert, Mary, Thummel, Kenneth, Mao, Qingcheng

“…Glyburide (Gly) is routinely used to treat hyperglycemia during pregnancy. Our objective was to determine if maternal‐fetal disposition of Gly and metabolites…”
Get full text

Identification of Proline Residues In or Near the Transmembrane Helices of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) Important for Transport Activity and Substrate Specificity by Ni, Zhanglin, Bikadi, Zsolt, Shuster, Diana L., Zhao, Chunsheng, Rosenberg, Mark F., Mao, Qingcheng

“…The human breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance and mediates the active efflux of drugs and xenobiotics. BCRP contains one…”
Get full text