Search Results - "Shur, D."

Estrogen, Efferent Ductules, and the Epididymis by Joseph, Avenel, Shur, Barry D, Hess, Rex A

“…Estrogen's presence in the male reproductive system has been known for over 60 years, but its potential function in the epididymis remains an important area of…”
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Identification of Mouse Sperm SED1, a Bimotif EGF Repeat and Discoidin-Domain Protein Involved in Sperm-Egg Binding by Ensslin, Michael A, Shur, Barry D

“…We report the identification of SED1, a protein required for mouse sperm binding to the egg zona pellucida. SED1 is homologous to a small group of secreted…”
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Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium by Bu, Heng-Fu, Zuo, Xiu-Li, Wang, Xiao, Ensslin, Michael A, Koti, Vjola, Hsueh, Wei, Raymond, Adam S, Shur, Barry D, Tan, Xiao-Di

“…Milk fat globule-EGF factor 8 (MFG-E8)/lactadherin participates in several cell surface-mediated regulatory events. Although its mRNA is present in the gut,…”
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Mouse oviduct-specific glycoprotein is an egg-associated ZP3-independent sperm-adhesion ligand by Lyng, Robert, Shur, Barry D

“…Mouse sperm-egg binding requires a multiplicity of receptor-ligand interactions, including an oviduct-derived, high molecular weight, wheat germ agglutinin…”
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The EGF Repeat and Discoidin Domain Protein, SED1/MFG-E8, Is Required for Mammary Gland Branching Morphogenesis by Ensslin, Michael A., Shur, Barry D.

“…SED1, also known as MFG-E8, is a secreted protein composed of two EGF repeats (the second of which contains an RGD motif) and two discoidin/Factor V/VIII C…”
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Identifying Complete Responders Following Chemotherapy-only Neoadjuvant Treatment for Rectal Cancer: Role of MRI by Santiago, Inês, Shur, Joshua D

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novel role for SED1 (MFG-E8) in maintaining the integrity of the epididymal epithelium by Raymond, Adam S, Shur, Barry D

“…The epididymis is a highly convoluted tubule that connects the testis with the vas deferens, and in which mammalian sperm acquire the ability to fertilize…”
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Reassessing the role of protein-carbohydrate complementarity during sperm-egg interactions in the mouse by Shur, Barry D

“…Despite years of intense study by many investigators, it may appear that we have made little progress towards a molecular understanding of mammalian sperm…”
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Cell adhesion and fertilization: Steps in oocyte transport, sperm-zona pellucida interactions, and sperm-egg fusion by TALBOT, Prudence, SHUR, Barry D, MYLES, Diana G

“…Fertilization in mammals requires the successful completion of many steps, starting with the transport of gametes in the reproductive tract and ending with…”
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Core fucosylation is required for midline patterning during zebrafish development by Seth, Anandita, Machingo, Quentin J., Fritz, Andreas, Shur, Barry D.

“…Complex carbohydrates represent one of the most polymorphic classes of macromolecules, but their functions during embryonic development remain poorly defined…”
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Radiomics in Oncology: A Practical Guide by Shur, Joshua D., Doran, Simon J., Kumar, Santosh, ap Dafydd, Derfel, Downey, Kate, O’Connor, James P. B., Papanikolaou, Nikolaos, Messiou, Christina, Koh, Dow-Mu, Orton, Matthew R.

“…Radiomics refers to the extraction of mineable data from medical imaging and has been applied within oncology to improve diagnosis, prognostication, and…”
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Loss of SED1/MFG-E8 results in altered luminal physiology in the epididymis by Raymond, Adam S., Elder, Brooke, Ensslin, Michael, Shur, Barry D.

“…SED1/MFG‐E8, herein referred to as SED1, is a bimotif adhesive protein with ascribed functions in a range of cell–cell interactions, including sperm‐egg…”
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Characterization of a novel ZP3-independent sperm-binding ligand that facilitates sperm adhesion to the egg coat by Rodeheffer, Carey, Shur, Barry D

“…During mammalian fertilization, sperm adhere to the extracellular coat of the egg, or zona pellucida, in a species-specific manner. In mouse, evidence suggests…”
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The mouse gamete adhesin, SED1, is expressed on the surface of acrosome-intact human sperm by Copland, Susannah D., M.D, Murphy, Ana A., M.D, Shur, Barry D., Ph.D

“…Objective To determine whether SED1, a protein secreted by the mouse epididymis that coats sperm and participates in sperm adhesion to the zona pellucida, is…”
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SED1 function during mammalian sperm–egg adhesion by Shur, Barry D, Ensslin, Michael A, Rodeheffer, Carey

“…A prerequisite for successful fertilization is the species-specific binding of sperm to the extracellular coat of the egg. Gamete binding triggers the release…”
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SED1/MFG-E8: A Bi-Motif protein that orchestrates diverse cellular interactions by Raymond, Adam, Ensslin, Michael A., Shur, Barry D.

“…MFG‐E8 was initially identified as a principle component of the Milk Fat Globule, a membrane‐encased collection of proteins and triglycerides that bud from the…”
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Sperm from β1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly by Lu, Qingxian, Shur, Barry D.

“…ABSTRACT A variety of sperm surface components have been suggested to mediate gamete recognition by binding to glycoside ligands on the egg coat glycoprotein…”
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Epididymal Hypo-Osmolality Induces Abnormal Sperm Morphology and Function in the Estrogen Receptor Alpha Knockout Mouse1 by Joseph, Avenel, Shur, Barry D, Ko, CheMyong, Chambon, Pierre, Hess, Rex A

“…Estrogen receptor-alpha (ESR1) is highly expressed in the efferent ductules of all species studied as well as in the epididymal epithelium in mice and other…”
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Activation of a G Protein Complex by Aggregation of β-1,4- Galactosyltransferase on the Surface of Sperm by Gong, Xiaohai, Dubois, Daniel H., Miller, David J., Shur, Barry D.

“…Fertilization is initiated by the species-specific binding of sperm to the extracellular coat of the egg. One sperm receptor for the mouse egg is…”
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Absence of Estrogen Receptor Alpha Leads to Physiological Alterations in the Mouse Epididymis and Consequent Defects in Sperm Function1 by Joseph, Avenel, Hess, Rex A, Schaeffer, David J, Ko, CheMyong, Hudgin-Spivey, Susan, Chambon, Pierre, Shur, Barry D

“…Male mice deficient in ESR1 (ERalpha) (Esr1KO mice) are infertile, and sperm recovered from the cauda epididymis exhibit reduced motility and fail to fertilize…”
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