Search Results - "Shungo Adachi"

Non-destructive and efficient method for obtaining miRNA information in cells by artificial extracellular vesicles by Maeda, Fumio, Adachi, Shungo, Natsume, Tohru

“…In recent years, research has explored the use of microRNA (miRNA) analysis in extracellular vesicles (EVs) as a minimally invasive strategy for the diagnosis…”
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Nuclear RNA export factor variant initiates piRNA‐guided co‐transcriptional silencing by Murano, Kensaku, Iwasaki, Yuka W, Ishizu, Hirotsugu, Mashiko, Akane, Shibuya, Aoi, Kondo, Shu, Adachi, Shungo, Suzuki, Saori, Saito, Kuniaki, Natsume, Tohru, Siomi, Mikiko C, Siomi, Haruhiko

“…The PIWI‐interacting RNA (piRNA) pathway preserves genomic integrity by repressing transposable elements (TEs) in animal germ cells. Among PIWI‐clade proteins…”
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RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease by Kato, Kazuki, Okazaki, Sae, Schmitt-Ulms, Cian, Jiang, Kaiyi, Zhou, Wenyuan, Ishikawa, Junichiro, Isayama, Yukari, Adachi, Shungo, Nishizawa, Tomohiro, Makarova, Kira S, Koonin, Eugene V, Abudayyeh, Omar O, Gootenberg, Jonathan S, Nishimasu, Hiroshi

“…The type III-E CRISPR-Cas7-11 effector binds a CRISPR RNA (crRNA) and the putative protease Csx29 and catalyzes crRNA-guided RNA cleavage. We report…”
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The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function by Yamaguchi, Tomokazu, Suzuki, Takashi, Sato, Teruki, Takahashi, Akinori, Watanabe, Hiroyuki, Kadowaki, Ayumi, Natsui, Miyuki, Inagaki, Hideaki, Arakawa, Satoko, Nakaoka, Shinji, Koizumi, Yukio, Seki, Shinsuke, Adachi, Shungo, Fukao, Akira, Fujiwara, Toshinobu, Natsume, Tohru, Kimura, Akinori, Komatsu, Masaaki, Shimizu, Shigeomi, Ito, Hiroshi, Suzuki, Yutaka, Penninger, Josef M, Yamamoto, Tadashi, Imai, Yumiko, Kuba, Keiji

“…Shortening and removal of the polyadenylate [poly(A)] tail of mRNA, a process called deadenylation, is a key step in mRNA decay that is mediated through the…”
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Plasma proteomics and lipidomics facilitate elucidation of the link between Alzheimer's disease development and vessel wall fragility by Tokuoka, Suzumi M., Hamano, Fumie, Kobayashi, Ayako, Adachi, Shungo, Andou, Tomohiro, Natsume, Tohru, Oda, Yoshiya

“…Proximity Extension Assay (PEA) and mass spectrometry (MS) methodologies were utilized for the proteomic and lipidomic characterization of plasma specimens…”
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LARP1 specifically recognizes the 3′ terminus of poly(A) mRNA by Aoki, Kazuma, Adachi, Shungo, Homoto, Masae, Kusano, Hideo, Koike, Katsuyuki, Natsume, Tohru

“…•We purified specific RNPs by immunoprecipitation using a FLAG-tagged antisense LNA.•We identified the components of RNPs using an ultrasensitive mass…”
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Sense-overlapping lncRNA as a decoy of translational repressor protein for dimorphic gene expression by Perez, Christelle Alexa Garcia, Adachi, Shungo, Nong, Quang Dang, Adhitama, Nikko, Matsuura, Tomoaki, Natsume, Toru, Wada, Tadashi, Kato, Yasuhiko, Watanabe, Hajime

“…Long noncoding RNAs (lncRNAs) are vastly transcribed and extensively studied but lncRNAs overlapping with the sense orientation of mRNA have been poorly…”
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CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner by Mohamed, Haytham Mohamed Aly, Takahashi, Akinori, Nishijima, Saori, Adachi, Shungo, Murai, Iori, Okamura, Hitoshi, Yamamoto, Tadashi

“…Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in…”
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Novel approach for reconstruction of the three-dimensional biliary system in decellularized liver scaffold using hepatocyte progenitors by Hirukawa, Kazuya, Yagi, Hiroshi, Kuroda, Kohei, Watanabe, Masafumi, Nishi, Kotaro, Nagata, Shogo, Abe, Yuta, Kitago, Minoru, Adachi, Shungo, Sudo, Ryo, Kitagawa, Yuko

“…Reconstruction of the biliary system is indispensable for the regeneration of transplantable liver grafts. Here, we report the establishment of the first…”
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Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development by Suzuki, Toru, Adachi, Shungo, Kikuguchi, Chisato, Shibata, Shinsuke, Nishijima, Saori, Kawamoto, Yurie, Iizuka, Yusuke, Koseki, Haruhiko, Okano, Hideyuki, Natsume, Tohru, Yamamoto, Tadashi

“…Transcripts of ( ), , and ( ) genes are highly expressed in mouse fetal liver, but decrease drastically during maturation. While transcriptional regulation of…”
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Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity by Takahashi, Akinori, Adachi, Shungo, Morita, Masahiro, Tokumasu, Miho, Natsume, Tohru, Suzuki, Toru, Yamamoto, Tadashi

“…Uncoupling protein 1 (Ucp1) contributes to thermogenesis, and its expression is regulated at the transcriptional level. Here, we show that Ucp1 expression is…”
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Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics by Kato, Akihisa, Adachi, Shungo, Kawano, Shuichi, Takeshima, Kousuke, Watanabe, Mizuki, Kitazume, Shinobu, Sato, Ryota, Kusano, Hideo, Koyanagi, Naoto, Maruzuru, Yuhei, Arii, Jun, Hatta, Tomohisa, Natsume, Tohru, Kawaguchi, Yasushi

“…Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic…”
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CELF1 represses Doublesex1 expression via its 5’ UTR in the crustacean Daphnia magna by Tirta, Yusrifar Kharisma, Adachi, Shungo, Perez, Christelle Alexa Garcia, Adhitama, Nikko, Nong, Quang Dang, Natsume, Toru, Kato, Yasuhiko, Watanabe, Hajime

“…In sex determination of the crustacean Daphnia magna , male-specific expression of DM-domain transcription factor Doublesex1 (Dsx1) orchestrates the male…”
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ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway by Adachi, Shungo, Homoto, Masae, Tanaka, Rikou, Hioki, Yusaku, Murakami, Hiroshi, Suga, Hiroaki, Matsumoto, Masaki, Nakayama, Keiichi I, Hatta, Tomohisa, Iemura, Shun-ichiro, Natsume, Tohru

“…Low-density lipoprotein receptor (LDLR) mRNA is unstable, but is stabilized upon extracellular signal-regulated kinase (ERK) activation, possibly through the…”
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A Novel Approach to Orthotopic Hepatocyte Transplantation Engineered With Liver Hydrogel for Fibrotic Livers, Enhancing Cell-Cell Interaction and Angiogenesis by Udagawa, Daisuke, Nagata, Shogo, Yagi, Hiroshi, Nishi, Kotaro, Morisaku, Toshinori, Adachi, Shungo, Nakano, Yutaka, Tanaka, Masayuki, Hori, Shutaro, Hasegawa, Yasushi, Abe, Yuta, Kitago, Minoru, Kitagawa, Yuko

“…Hepatocyte transplantation (HCT) is a potential bridging therapy or an alternative to liver transplantation. Conventionally, single-cell hepatocytes are…”
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Transplantation of bioengineered liver capable of extended function in a preclinical liver failure model by Higashi, Hisanobu, Yagi, Hiroshi, Kuroda, Kohei, Tajima, Kazuki, Kojima, Hideaki, Nishi, Kotaro, Morisaku, Toshinori, Hirukawa, Kazuya, Fukuda, Kazumasa, Matsubara, Kentaro, Kitago, Minoru, Shinoda, Masahiro, Obara, Hideaki, Adachi, Shungo, Nishimura, Kumiko, Natsume, Tohru, Tomi, Masatoshi, Soto‐Gutierrez, Alejandro, Kitagawa, Yuko

“…Unlimited organ availability would represent a paradigm shift in transplantation. Long‐term in vivo engraftment and function of scaled‐up bioengineered liver…”
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Simulating dual-arm robot motions to avoid collision by rigid body dynamics for laboratory bench work by Ueno, Yutaka, Miyata, Natsuki, Yamanobe, Natsuki, Adachi, Shungo, Mitsuyama, Totai

“…Purpose To develop a method by which a dual-arm robot can simulate collision avoidance while replicating motions of a laboratory biologist. Methods Using a…”
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Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 1 by Maeda, Fumio, Kato, Akihisa, Takeshima, Kosuke, Shibazaki, Misato, Sato, Ryota, Shibata, Takuma, Miyake, Kensuke, Kozuka-Hata, Hiroko, Oyama, Masaaki, Shimizu, Eigo, Imoto, Seiya, Miyano, Satoru, Adachi, Shungo, Natsume, Tohru, Takeuchi, Koh, Maruzuru, Yuhei, Koyanagi, Naoto, Jun, Arii, Yasushi, Kawaguchi

“…This study developed a system consisting of two rounds of screening cellular proteins involved in the nuclear egress of herpes simplex virus 1 (HSV-1). Using…”
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CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability by Inoue, Takeshi, Morita, Masahiro, Hijikata, Atsushi, Fukuda-Yuzawa, Yoko, Adachi, Shungo, Isono, Kyoichi, Ikawa, Tomokatsu, Kawamoto, Hiroshi, Koseki, Haruhiko, Natsume, Tohru, Fukao, Taro, Ohara, Osamu, Yamamoto, Tadashi, Kurosaki, Tomohiro

“…The CCR4-NOT deadenylase complex plays crucial roles in mRNA decay and translational repression induced by poly(A) tail shortening. Although the in vitro…”
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m6A modification of HSATIII lncRNAs regulates temperature‐dependent splicing by Ninomiya, Kensuke, Iwakiri, Junichi, Aly, Mahmoud Khamis, Sakaguchi, Yuriko, Adachi, Shungo, Natsume, Tohru, Terai, Goro, Asai, Kiyoshi, Suzuki, Tsutomu, Hirose, Tetsuro

“…Nuclear stress bodies (nSBs) are nuclear membraneless organelles formed around stress‐inducible HSATIII architectural long noncoding RNAs (lncRNAs). nSBs…”
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