Search Results - "Shumilin, Igor A"

Structural and functional insight into the universal stress protein family by Tkaczuk, Karolina L., A. Shumilin, Igor, Chruszcz, Maksymilian, Evdokimova, Elena, Savchenko, Alexei, Minor, Wladek

“…We present the crystal structures of two universal stress proteins (USP) from Archaeoglobus fulgidus and Nitrosomonas europaea in both apo‐ and ligand‐bound…”
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Identification of Unknown Protein Function Using Metabolite Cocktail Screening by Shumilin, Igor A., Cymborowski, Marcin, Chertihin, Olga, Jha, Kula N., Herr, John C., Lesley, Scott A., Joachimiak, Andrzej, Minor, Wladek

“…Proteins of unknown function comprise a significant fraction of sequenced genomes. Defining the roles of these proteins is vital to understanding cellular…”
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Disulfide Bond Oxidoreductase DsbA2 of Legionella pneumophila Exhibits Protein Disulfide Isomerase Activity by Kpadeh, Zegbeh Z, Jameson-Lee, Max, Yeh, Anthony J, Chertihin, Olga, Shumilin, Igor A, Dey, Rafik, Day, Shandra R, Hoffman, Paul S

“…The extracytoplasmic assembly of the Dot/Icm type IVb secretion system (T4SS) of Legionella pneumophila is dependent on correct disulfide bond (DSB) formation…”
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A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1 by Mussakhmetov, Arman, Shumilin, Igor A., Nugmanova, Raushan, Shabalin, Ivan G., Baizhumanov, Timur, Toibazar, Daulet, Khassenov, Bekbolat, Minor, Wladek, Utepbergenov, Darkhan

“…Mutations in the human protein DJ-1 cause early onset of Parkinson's disease. A reactive cysteine residue (Cys106) of DJ-1 is crucial for its protective…”
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The High-Resolution Structure of 3-Deoxy-d-arabino-heptulosonate-7-phosphate Synthase Reveals a Twist in the Plane of Bound Phosphoenolpyruvate by Shumilin, Igor A, Bauerle, Ronald, Kretsinger, Robert H

“…3-Deoxy-d-arabino-heptulosonate-7-phosphate synthase (DAHPS), the first enzyme of the aromatic biosynthetic pathway in microorganisms and plants, catalyzes the…”
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Corrigendum to “A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1” [Biochem. Biophys. Res. Commun. 504 (1) (2018 Sep 26) 328–333] by Mussakhmetov, Arman, Shumilin, Igor A., Nugmanova, Raushan, Shabalin, Ivan G., Baizhumanov, Timur, Toibazar, Daulet, Khassenov, Bekbolat, Minor, Wladek, Utepbergenov, Darkhan

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Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae by Hou, Jing, Zheng, Heping, Chruszcz, Maksymilian, Zimmerman, Matthew D, Shumilin, Igor A, Osinski, Tomasz, Demas, Matt, Grimshaw, Sarah, Minor, Wladek

“…β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital…”
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The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects by Raddum, Aase M., Hollås, Hanne, Shumilin, Igor A., Henklein, Petra, Kretsinger, Robert, Fossen, Torgils, Vedeler, Anni

“…The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents…”
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Characterization of the Gating Brake in the I-II Loop of Cav3.2 T-type Ca2+ Channels by Arias-Olguín, Imilla I., Vitko, Iuliia, Fortuna, Michal, Baumgart, Joel P., Sokolova, Svetlana, Shumilin, Igor A., Van Deusen, Amy, Soriano-García, Manuel, Gomora, Juan C., Perez-Reyes, Edward

“…Mutations in the I-II loop of Cav3.2 channels were discovered in patients with childhood absence epilepsy. All of these mutations increased the surface…”
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Substrate Specificity of Mammalian N-Terminal α-Amino Methyltransferase NRMT by Petkowski, Janusz J, Schaner Tooley, Christine E, Anderson, Lissa C, Shumilin, Igor A, Balsbaugh, Jeremy L, Shabanowitz, Jeffrey, Hunt, Donald F, Minor, Wladek, Macara, Ian G

“…N-Terminal methylation of free α-amino groups is a post-translational modification of proteins that was first described 30 years ago but has been studied very…”
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Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2 by Shetty, Jagathpala, Sinville, Rondedrick, Shumilin, Igor A., Minor, Wladek, Zhang, Jianhai, Hawkinson, Jon E., Georg, Gunda I., Flickinger, Charles J., Herr, John C.

“…The testis-specific serine/threonine kinase 2 (TSSK2) has been proposed as a candidate male contraceptive target. Development of a selective inhibitor for this…”
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Biochemical and Structural Characterization of Apolipoprotein A-I Binding Protein, a Novel Phosphoprotein with a Potential Role in Sperm Capacitation by Jha, Kula N, Shumilin, Igor A, Digilio, Laura C, Chertihin, Olga, Zheng, Heping, Schmitz, Gerd, Visconti, Pablo E, Flickinger, Charles J, Minor, Wladek, Herr, John C

“…The physiological changes that sperm undergo in the female reproductive tract rendering them fertilization-competent constitute the phenomenon of capacitation…”
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Edc3 function in yeast and mammals is modulated by interaction with NAD-related compounds by Walters, Robert W, Shumilin, Igor A, Yoon, Je-Hyun, Minor, Wladek, Parker, Roy

“…The control of mRNA translation and degradation is mediated in part by a set of proteins that can inhibit translation and promote decapping, as well as…”
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Structure and characterization of the 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Aeropyrum pernix by Zhou, Lily, Wu, Jing, Vijayalakshmi, J., Shumilin, Igor A., Bauerle, Ronald, Kretsinger, Robert H., Woodard, Ronald W.

“…[Display omitted] ▸ We investigate the DAH7P synthase from Aeropyrum pernix, a primitive archaebacterium. ▸ We present the biochemical characterization and…”
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Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric regulation by Shumilin, Igor A, Bauerle, Ronald, Wu, Jing, Woodard, Ronald W, Kretsinger, Robert H

“…3-Deoxy-d-arabino-heptulosonate-7-phosphate synthase (DAHPS) catalyzes the first reaction of the aromatic biosynthetic pathway in bacteria, fungi, and plants,…”
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Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus by Luo, Hai-Bin, Knapik, Aleksandra A., Petkowski, Janusz J., Demas, Matthew, Shumilin, Igor A., Zheng, Heping, Chruszcz, Maksymilian, Minor, Wladek

“…Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of a myriad of insidious and intractable infections in humans, especially in patients with…”
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Crystal structure of phenylalanine-regulated 3-deoxy- D- arabino-heptulosonate-7-phosphate synthase from Escherichia coli by Shumilin, Igor A, Kretsinger, Robert H, Bauerle, Ronald H

“…Background: In microorganisms and plants the first step in the common pathway leading to the biosynthesis of aromatic compounds is the stereospecific…”
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The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of α + β fold by Wang, Shuren, Kirillova, Olga, Chruszcz, Maksymilian, Gront, Dominik, Zimmerman, Matthew D., Cymborowski, Marcin T., Shumilin, Igor A., Skarina, Tatiana, Gorodichtchenskaia, Elena, Savchenko, Alexei, Edwards, Aled M., Minor, Wladek

“…The structure of AF2331, a 11‐kDa orphan protein of unknown function from Archaeoglobus fulgidus, was solved by Se‐Met MAD to 2.4 Å resolution. The structure…”
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Allosteric Inhibition of 3-Deoxy- d- arabino-heptulosonate-7-phosphate Synthase Alters the Coordination of Both Substrates by Shumilin, Igor A., Zhao, Chang, Bauerle, Ronald, Kretsinger, Robert H.

“…3-Deoxy- d- arabino-heptulosonate-7-phosphate synthase (DAHPS), the first enzyme of the aromatic biosynthetic pathway in microorganisms and plants, catalyzes…”
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An extremely SAD case: structure of a putative redox-enzyme maturation protein from Archaeoglobus fulgidus at 3.4 Å resolution by Kirillova, Olga, Chruszcz, Maksymilian, Shumilin, Igor A., Skarina, Tatiana, Cymborowski, Marcin, Gorodichtchenskaia, Elena, Edwards, Aled, Savchenko, Alexei, Minor, Wladek

“…This paper describes the crystal structure of AF0173, a putative redox‐enzyme maturation protein (REMP) from Archaeoglobus fulgidus. The REMPs serve as…”
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