Search Results - "Shumate, Margaret L."

Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes by Ahmed, Tamer A, Buzzelli, Mark D, Lang, Charles H, Capen, John B, Shumate, Margaret L, Navaratnarajah, Maithili, Nagarajan, Murali, Cooney, Robert N

“…During systemic inflammation, the liver becomes unresponsive to growth hormone (GH), resulting in decreased plasma insulin-like growth factor-I (IGF-I) with…”
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Skeletal muscle catabolism in trinitrobenzene sulfonic acid–induced murine colitis by Puleo, Frances, Meirelles, Katia, Navaratnarajah, Maithili, Fitzpatrick, Leo, Shumate, Margaret L, Cooney, Robert N, Lang, Charles H

“…Abstract The present study determined whether the muscle atrophy produced by colitis is associated with altered rates of muscle protein synthesis or…”
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Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling by Yumet, Gladys, Shumate, Margaret L, Bryant, D Patrick, Lang, Charles H, Cooney, Robert N

“…OBJECTIVE:During sepsis, a two- to four-fold increase in circulating growth hormone (GH) is seen with 40–50% reductions in plasma insulin-like growth factor…”
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Nuclear Factor-κB Mediates the Inhibitory Effects of Tumor Necrosis Factor-α on Growth Hormone-Inducible Gene Expression in Liver by Buzzelli, Mark D, Nagarajan, Murali, Radtka, John F, Shumate, Margaret L, Navaratnarajah, Maithili, Lang, Charles H, Cooney, Robert N

“…TNF inhibits serine protease inhibitor 2.1 (Spi 2.1) and IGF-I gene expression by GH in CWSV-1 hepatocytes. The current study describes construction of a…”
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Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes by Shumate, Margaret L, Yumet, Gladys, Ahmed, Tamer A, Cooney, Robert N

“…Sepsis results in hepatic "growth hormone (GH) resistance" with reductions in plasma IGF-I despite a two- to fourfold increase in circulating GH. In this…”
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Growth hormone does not attenuate the inhibitory effects of sepsis on wound healing by Stamm, Jason, Cooney, Robert N, Maish III, George O, Shumate, Margaret L, Lang, Charles H, Ehrlich, H. Paul, Vary, Thomas C

“…Chronic abdominal sepsis is associated with impaired tissue repair. Treatment of burn patients with growth hormone results in improved healing of skin graft…”
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Tumor necrosis factor mediates hepatic growth hormone resistance during sepsis by Yumet, Gladys, Shumate, Margaret L, Bryant, Patrick, Lin, Cheng-Mao, Lang, Charles H, Cooney, Robert N

“…During sepsis, growth hormone (GH) resistance contributes to the catabolism of muscle protein. To determine the role of tumor necrosis factor (TNF) as a…”
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Skeletal Muscle Catabolism in TNBS-Induced Murine Colitis by Puleo, Frances, Meirelles, Katia, Navaratnarajah, Maithili, Fitzpatrick, Leo, Shumate, Margaret L., Cooney, Robert N., Lang, Charles H.

“…The present study determined whether the muscle atrophy produced by colitis is associated with altered rates of muscle protein synthesis or degradation, as…”
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Nuclear factor kappaB mediates the inhibitory effects of interleukin-1 on growth hormone-inducible gene expression by Buzzelli, Mark D, Navaratnarajah, Maithili, Ahmed, Tamer, Nagarajan, Murali, Shumate, Margaret L, Lang, Charles H, Cooney, Robert N

“…Hepatic expression of growth hormone (GH)-inducible genes serine protease inhibitor (Spi 2.1) and insulin-like growth factor (IGF)-I are inhibited by…”
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Nuclear factor-kappaB mediates the inhibitory effects of tumor necrosis factor-alpha on growth hormone-inducible gene expression in liver by Buzzelli, Mark D, Nagarajan, Murali, Radtka, John F, Shumate, Margaret L, Navaratnarajah, Maithili, Lang, Charles H, Cooney, Robert N

“…TNF inhibits serine protease inhibitor 2.1 (Spi 2.1) and IGF-I gene expression by GH in CWSV-1 hepatocytes. The current study describes construction of a…”
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Nuclear Factor-κB Mediates the Inhibitory Effects of Tumor Necrosis Factor-a on Growth Hormone-Inducible Gene Expression in Liver by BUZZELLI, Mark D, NAGARAJAN, Murali, RADTKA, John F, SHUMATE, Margaret L, NAVARATNARAJAH, Maithili, LANG, Charles H, COONEY, Robert N

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Mechanism of IL-1 induced inhibition of protein synthesis in skeletal muscle by Cooney, R N, Maish, 3rd, G O, Gilpin, T, Shumate, M L, Lang, C H, Vary, T C

“…Chronic interleukin (IL)-1 administration is associated with negative nitrogen balance and the loss of lean body mass. To elucidate the molecular mechanism(s)…”
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Tumor Necrosis Factor Binding Protein Improves Incisional Wound Healing in Sepsis by Maish, George O., Shumate, Margaret L., Ehrlich, H.Paul, Cooney, Robert N.

“…Background.Sepsis is associated with poor wound healing; however, the exact role of tumor necrosis factor (TNF) as a mediator of sepsis-induced alterations in…”
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CHRONIC IL-1 INFUSION ALTERS MUSCLE AND VISCERAL PROTEIN METABOLISM by Cooney, Robert N., Maish, George O., Shumate, Margaret L., Vary, Thomas C.

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Nuclear Factor κB Mediates the Inhibitory Effects of Interleukin-1 on Growth Hormone-Inducible Gene Expression by Buzzelli, Mark D., Navaratnarajah, Maithili, Ahmed, Tamer, Nagarajan, Murali, Shumate, Margaret L., Lang, Charles H., Cooney, Robert N.

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Nuclear Factor κB Mediates the Inhibitory Effects of lnterleukin-1 on Growth Hormone-lnducible Gene Expression. Discussion by BUZZELLI, Mark D, NAVARATNARAJAH, Maithili, AHMED, Tamer, NAGARAJAN, Murali, SHUMATE, Margaret L, LANG, Charles H, COONEY, Robert N, COIMBRA, Raul, GAMELLI, Richard L, BUZZELLI, Mark

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Interleukin-1 Receptor Antagonist Attenuates Tumor Necrosis Factor-Induced Alterations in Wound Breaking Strength by Maish, George O., Shumate, Margaret L., Ehrlich, H. Paul, Vary, Thomas C., Cooney, Robert N.

“…BACKGROUND:Tumor necrosis factor (TNF) is an important mediator of impaired wound healing during sepsis. To determine whether the inhibitory effects of…”
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