Search Results - "Shulman, G. I"

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β-cell dysfunction by Boden, G., Shulman, G. I.

“…Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver and pancreas. However, chronically elevated plasma FFA appear…”
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Cellular mechanism of insulin resistance: potential links with inflammation by Perseghin, G, Petersen, K, Shulman, G.I

“…Insulin resistance is a pivotal feature in the pathogenesis of type 2 diabetes, and it may be detected 10-20 y before the clinical onset of hyperglycemia…”
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Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade by GRIFFIN, M. E, MARCUCCI, M. J, CLINE, G. W, BELL, K, BARUCCI, N, LEE, D, GOODYEAR, L. J, KRAEGEN, E. W, WHITE, M. F, SHULMAN, G. I

“…Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. M E…”
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Disruption of IRS-2 causes type 2 diabetes in mice by White, Morris F, Withers, Dominic J, Gutierrez, Julio Sanchez, Towery, Heather, Burks, Deborah J, Ren, Jian-Ming, Previs, Stephen, Zhang, Yitao, Bernal, Dolores, Pons, Sebastian, Shulman, Gerald I, Bonner-Weir, Susan

“…Human type 2 diabetes is characterized by defects in both insulin action and insulin secretion. It has been difficult to identify a single molecular…”
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Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans by RODEN, M, STINGL, H, CHANDRAMOULI, V, SCHUMANN, W. C, HOFER, A, LANDAU, B. R, NOWOTNY, P, WALDHÄUSL, W, SHULMAN, G. I

“…Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. M Roden , H Stingl , V Chandramouli , W C…”
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Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance by Weismann, D, Erion, D. M, Ignatova-Todorava, I, Nagai, Y, Stark, R, Hsiao, J. J, Flannery, C, Birkenfeld, A. L, May, T, Kahn, M, Zhang, D, Yu, X. X, Murray, S. F, Bhanot, S, Monia, B. P, Cline, G. W, Shulman, G. I, Samuel, V. T

“…Aims/hypothesis Insulin action is purportedly modulated by Drosophila tribbles homologue 3 (TRIB3), which in vitro prevents thymoma viral proto-oncogene (AKT)…”
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Mechanism by which metformin reduces glucose production in type 2 diabetes by HUNDAL, Ripudaman S, KRSSAK, Martin, SHULMAN, Gerald I, DUFOUR, Sylvie, LAURENT, Didier, LEBON, Vincent, CHANDRAMOULI, Visvanathan, INZUCCHI, Silvio E, SCHUMANN, William C, PETERSEN, Kitt F, LANDAU, Bernard R

“…Mechanism by which metformin reduces glucose production in type 2 diabetes. R S Hundal , M Krssak , S Dufour , D Laurent , V Lebon , V Chandramouli , S E…”
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Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study by PERSEGHIN, G, GHOSH, S, GEROW, K, SHULMAN, G. I

“…First-degree relatives of NIDDM patients have an approximately 40% lifetime risk of developing diabetes, and insulin resistance is the best predictor. However,…”
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Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes by Fernández, A M, Kim, J K, Yakar, S, Dupont, J, Hernandez-Sanchez, C, Castle, A L, Filmore, J, Shulman, G I, Le Roith, D

“…Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major…”
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Mechanism of troglitazone action in type 2 diabetes by PETERSEN, K. F, KRSSAK, M, INZUCCHI, S, CLINE, G. W, DUFOUR, S, SHULMAN, G. I

“…Mechanism of troglitazone action in type 2 diabetes. K F Petersen , M Krssak , S Inzucchi , G W Cline , S Dufour and G I Shulman Department of Internal…”
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Mechanism of free fatty acid-induced insulin resistance in humans by Roden, M, Price, T B, Perseghin, G, Petersen, K F, Rothman, D L, Cline, G W, Shulman, G I

“…To examine the mechanism by which lipids cause insulin resistance in humans, skeletal muscle glycogen and glucose-6-phosphate concentrations were measured…”
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Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes by Cline, Gary W, Petersen, Kitt Falk, Krssak, Martin, Shen, Jun, Hundal, Ripudaman S, Trajanoski, Zlatko, Inzucchi, Silvio, Dresner, Alan, Rothman, Douglas L, Shulman, Gerald I

“…Diabetes mellitus is the most common metabolic disease in the world. 1 Over 90 percent of patients with diabetes have type 2, and although the primary factors…”
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Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke by KERNAN, W. N, INZUCCHI, S. E, VISCOLI, C. M, BRASS, L. M, BRAVATA, D. M, SHULMAN, G. I, MCVEETY, J. C, HORWITZ, R. I

“…To determine the prevalence of impaired insulin sensitivity among nondiabetic patients with a recent TIA or nondisabling ischemic stroke. Eligible subjects…”
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Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study by Perseghin, G., Ghosh, S., Gerow, K., Shulman, G. I.

“…Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study. G Perseghin , S Ghosh , K Gerow and G I Shulman Department of…”
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Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus by Inzucchi, Silvio E, Maggs, David G, Spollett, Geralyn R, Page, Stephanie L, Rife, Frances S, Walton, Veronika, Shulman, Gerald I

“…Hyperglycemia in patients with non-insulin-dependent (type II) diabetes mellitus is caused by peripheral insulin resistance, which results in decreased…”
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Cellular mechanisms of insulin resistance in humans by Shulman, Gerald I

“…Carbon nuclear magnetic resonance ( 13C NMR) spectroscopy and phosphorus ( 31P) NMR spectroscopy have been used to help define the contribution of…”
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Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4 by Kim, J K, Zisman, A, Fillmore, J J, Peroni, O D, Kotani, K, Perret, P, Zong, H, Dong, J, Kahn, C R, Kahn, B B, Shulman, G I

“…Using cre/loxP gene targeting, transgenic mice with muscle-specific inactivation of the GLUT4 gene (muscle GLUT4 KO) were generated and shown to develop a…”
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Cellular mechanisms of insulin resistance by Shulman, G I

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Lipid-dependent control of hepatic glycogen stores in healthy humans by STINGL, H, KRSSAK, M, KREBS, M, BISCHOF, M. G, NOWOTNY, P, FÜRNSINN, C, SHULMAN, G. I, WALDHÄUSL, W, RODEN, M

“…Non-esterified fatty acids and glycerol could stimulate gluconeogenesis and also contribute to regulating hepatic glycogen stores. We examined their effect on…”
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Metabolic effects of Troglitazone monotherapy in type 2 diabetes mellitus : A randomized, double-blind, placebo-controlled trial by MAGGS, D. G, BUCHANAN, T. A, POLONSKY, K. S, SILVER, D, VALIQUETT, T. R, SHULMAN, G. I, BURANT, C. F, CLINE, G, GUMBINER, B, HSUEH, W. A, INZUCCHI, S, KELLEY, D, NOLAN, J, OLEFSKY, J. M

“…Troglitazone is a new insulin-sensitizing agent used to treat type 2 diabetes mellitus. The mechanism by which troglitazone exerts its effect on systemic…”
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