Search Results - "Shuler, Michael L."

Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening by Wang, Ying I., Abaci, Hasan Erbil, Shuler, Michael L.

“…ABSTRACT Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB) remains a formidable challenge for central nervous system drug…”
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Design and demonstration of a pumpless 14 compartment microphysiological system by Miller, Paula G., Shuler, Michael L.

“…ABSTRACT We describe a human “Body‐on‐a‐chip” device (or microphysiological system) that could be used to emulate drug distribution, metabolism, and action in…”
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Pumpless microfluidic platform for drug testing on human skin equivalents by Abaci, Hasan Erbil, Gledhill, Karl, Guo, Zongyou, Christiano, Angela M, Shuler, Michael L

“…Advances in bio-mimetic in vitro human skin models increase the efficiency of drug screening studies. In this study, we designed and developed a microfluidic…”
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Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs by Oleaga, Carlota, Bernabini, Catia, Smith, Alec S.T., Srinivasan, Balaji, Jackson, Max, McLamb, William, Platt, Vivien, Bridges, Richard, Cai, Yunqing, Santhanam, Navaneetha, Berry, Bonnie, Najjar, Sarah, Akanda, Nesar, Guo, Xiufang, Martin, Candace, Ekman, Gail, Esch, Mandy B., Langer, Jessica, Ouedraogo, Gladys, Cotovio, Jose, Breton, Lionel, Shuler, Michael L., Hickman, James J.

“…We report on a functional human model to evaluate multi-organ toxicity in a 4-organ system under continuous flow conditions in a serum-free defined medium…”
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Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow by Esch, Mandy B, Prot, Jean-Matthieu, Wang, Ying I, Miller, Paula, Llamas-Vidales, Jose Ricardo, Naughton, Brian A, Applegate, Dawn R, Shuler, Michael L

“…We have developed a low-cost liver cell culture device that creates fluidic flow over a 3D primary liver cell culture that consists of multiple liver cell…”
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Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability by Mahler, Gretchen J., Shuler, Michael L., Glahn, Raymond P.

“…Cocultures of two human cell lines, Caco-2 and HT29-MTX mucus-producing cells, have been incorporated into an in vitro digestion/cell culture model used to…”
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How multi-organ microdevices can help foster drug development by Esch, Mandy B., Smith, Alec S.T., Prot, Jean-Matthieu, Oleaga, Carlota, Hickman, James J., Shuler, Michael L.

“…Multi-organ microdevices can mimic tissue–tissue interactions that occur as a result of metabolite travel from one tissue to other tissues in vitro. These…”
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Pumpless, unidirectional microphysiological system for testing metabolism‐dependent chemotherapeutic toxicity by LaValley, Danielle J., Miller, Paula G., Shuler, Michael L.

“…Drug development is often hindered by the failure of preclinical models to accurately assess and predict the efficacy and safety of drug candidates…”
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Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation by Slaughter, Victoria L., Rumsey, John W., Boone, Rachel, Malik, Duaa, Cai, Yunqing, Sriram, Narasimhan Narasimhan, Long, Christopher J., McAleer, Christopher W., Lambert, Stephen, Shuler, Michael L., Hickman, J. J.

“…Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and strongly correlates with the growing incidence of obesity and type II diabetes…”
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novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers by Tatosian, Daniel A, Shuler, Michael L

“…Multidrug resistant (MDR) cancer is difficult to treat. Chemicals that are effective MDR modulators have never exited clinical trials as FDA approved products…”
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Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap by Sung, Jong Hwan, Shuler, Michael L.

“…Formation of air bubbles is a serious obstacle to a successful operation of a long-term microfluidic systems using cell culture. We developed a microscale…”
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Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS) by Sung, Jong Hwan, Wang, Ying, Shuler, Michael L.

“…Recent advances in organ-on-a-chip technology have resulted in numerous examples of microscale systems that faithfully mimic the physiology and pathology of…”
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On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships by McAleer, Christopher W., Pointon, Amy, Long, Christopher J., Brighton, Rocky L., Wilkin, Benjamin D., Bridges, L. Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P., Mettetal, Jerome T., Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T., Roles, Jeff L., Shuler, Michael L., Hickman, James J., Ewart, Lorna

“…Functional human-on-a-chip systems hold great promise to enable quantitative translation to in vivo outcomes. Here, we explored this concept using a pumpless…”
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Toward in vitro models of brain structure and function by Shuler, Michael L., Hickman, James J.

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Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity by Mahler, Gretchen J., Esch, Mandy B., Glahn, Raymond P., Shuler, Michael L.

“…The lining of the gastrointestinal (GI) tract is the largest surface exposed to the external environment in the human body. One of the main functions of the…”
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A hydrogel-based microfluidic device for the studies of directed cell migration by Cheng, Shing-Yi, Heilman, Steven, Wasserman, Max, Archer, Shivaun, Shuler, Michael L, Wu, Mingming

“…We have developed a hydrogel-based microfluidic device that is capable of generating a steady and long term linear chemical concentration gradient with no…”
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Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges by Sakolish, Courtney M., Esch, Mandy B., Hickman, James J., Shuler, Michael L., Mahler, Gretchen J.

“…Organ-on-a-chip devices have gained attention in the field of in vitro modeling due to their superior ability in recapitulating tissue environments compared to…”
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Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip by Sasserath, Trevor, Rumsey, John W., McAleer, Christopher W., Bridges, Lee Richard, Long, Christopher J., Elbrecht, Daniel, Schuler, Franz, Roth, Adrian, Bertinetti‐LaPatki, Christina, Shuler, Michael L., Hickman, James J.

“…A functional, human, multiorgan, pumpless, immune system‐on‐a‐chip featuring recirculating THP‐1 immune cells with cardiomyocytes, skeletal muscle, and liver…”
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Integration of Cell Culture and Microfabrication Technology by Park, Tai Hyun, Shuler, Michael L.

“…Recent progress in cell culture and microfabrication technologies has contributed to the development of cell‐based biosensors for the functional…”
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Design optimization of nano-grating surface plasmon resonance sensors by Yoon, Kyung Hun, Shuler, Michael L, Kim, Sung June

“…In this study, we propose nano-grating surface plasmon resonance (NGSPR) sensors and show the design optimization process. NGSPR sensors with line width less…”
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