Search Results - "Shuker, B"

Discovering High-Affinity Ligands for Proteins: SAR by NMR by Shuker, Suzanne B., Hajduk, Philip J., Meadows, Robert P., Fesik, Stephen W.

“…A nuclear magnetic resonance (NMR)-based method is described in which small organic molecules that bind to proximal subsites of a protein are identified,…”
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Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR by Hajduk, P. J, Sheppard, G, Nettesheim, D. G, Olejniczak, E. T, Shuker, S. B, Meadows, R. P, Steinman, D. H, Carrera, G. M, Marcotte, P. A, Severin, J, Walter, K, Smith, H, Gubbins, E, Simmer, R, Holzman, T. F, Morgan, D. W, Davidsen, S. K, Summers, J. B, Fesik, S. W

“…With the use of an NMR-based method, potent (IC50 < 25 nM) nonpeptide inhibitors of the matrix metalloproteinase stromelysin (MMP-3) were discovered. The…”
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Structure of Bcl-x-Bak peptide complex: recognition between regulators of apoptosis by Sattler, Michael, Nettesheim, David, Meadows, Robert P, Harlan, John E, Eberstadt, Matthias, Yoon, Ho Sup, Shuker, Suzanne B, Chang, Brian S, Minn, Andy J, Thompson, Craig B, Fesik, Stephen W

“…Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for…”
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NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein by Hajduk, Philip J, Dinges, Jürgen, Miknis, Gregory F, Merlock, Megan, Middleton, Tim, Kempf, Dale J, Egan, David A, Walter, Karl A, Robins, Terry S, Shuker, Suzy B, Holzman, Thomas F, Fesik, Stephen W

“…The E2 protein is required for the replication of human papillomaviruses (HPVs), which are responsible for anogenital warts and cervical carcinomas. Using an…”
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NMR-Based Modification of Matrix Metalloproteinase Inhibitors with Improved Bioavailability by Hajduk, Philip J, Shuker, Suzanne B, Nettesheim, David G, Craig, Richard, Augeri, David J, Betebenner, David, Albert, Daniel H, Guo, Yan, Meadows, Robert P, Xu, Lianhong, Michaelides, Michael, Davidsen, Steven K, Fesik, Stephen W

“…The NMR-based discovery of biaryl hydroxamate inhibitors of the matrix metalloproteinase stromelysin (MMP-3) has been previously described (Hajduk et al. J…”
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P83 Online Multidisciplinary Review of Point of Care Ultrasound Images During the COVID-19 Pandemic by Shuker, B A, Perry, J

“…Abstract   Point-of-care-ultrasound (POCUS) is a valuable diagnostic tool in intensive care. Evaluation of POCUS images acquired in our intensive care unit…”
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The 10 C-terminal residues of HTLV-I protease are not necessary for enzymatic activity by Herger, Bryan E., Mariani, Victoria L., Dennison, Kelly J., Shuker, Suzanne B.

“…Sequence alignment of human T-lymphotropic virus type I (HTLV-I) protease and other retroviral proteases reveals that the leukemia virus proteases contain…”
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C45 DYSPNEA: TAKES YOUR BREATH AWAY: Specialist pulmonologist Assessment avoids Unnecessary CT Pulmonary Angiography In Suspected Pulmonary Embolism by Shuker, B A, Saroka, M, Satterthwaite, L, Parr, D

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Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain by Zhou, M M, Huang, B, Olejniczak, E T, Meadows, R P, Shuker, S B, Miyazaki, M, Trüb, T, Shoelson, S E, Fesik, S W

“…We present the NMR structure of the PTB domain of insulin receptor substrate-1 (IRS-1) complexed to a tyrosine-phosphorylated peptide derived from the IL-4…”
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Heterodimerization Studies of Calix[4]arene Derivatives in Polar Solvents by Sasine, Joshua S, Brewster, R. Elizabeth, Caran, Kevin L, Bentley, Adrienne M, Shuker, Suzanne B

“…Several calix[4]arene derivatives propylated on the lower rim and substituted on the upper rim with amino or carboxyl groups have been synthesized. Examples…”
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Structure of Bcl-xL-Bak peptide complex : Recognition between regulators of apoptosis by SATTLER, M, LIANG, H, THOMPSON, C. B, FESIK, S. W, NETTESHEIM, D, MEADOWS, R. P, HARLAN, J. E, EBERSTADT, M, HO SUP YOON, SHUKER, S. B, CHANG, B. S, MINN, A. J

“…Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for…”
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Expression, purification, and refolding of mouse islet neogenesis associated protein-related protein for NMR studies by Kulis, Michael D., Shuker, Suzanne B.

“…Islet neogenesis associated protein-related protein (INGAPrP) is thought to be involved in the differentiation of non-insulin-producing cells to…”
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Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain by Zhou, Ming-Ming, Huang, Baohua, Olejniczak, Edward T, Meadows, Robert P, Shuker, Suzanne B, Miyazaki, Masaya, Trüb, Thomas, Shoelson, Steven E, Fesik, Stephen W

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Propofol metabolism in man during the anhepatic and reperfusion phases of liver transplantation by Gray, P A, Park, G R, Cockshott, I D, Douglas, E J, Shuker, B, Simons, P J

“…1. An i.v. dose of 14C-propofol (0.53 mg/kg) was administered to three male and three female patients during the anhepatic phase of liver transplantation,…”
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Identification of the RT–RH/IN cleavage site of HTLV-I by Mariani, Victoria L, Beckham Shuker, Suzanne

“…Human T-cell leukemia virus type 1 (HTLV-1) is a type C human retrovirus and is the causative agent of adult T-cell leukemia and other diseases. The enzymatic…”
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The metabolism of ICI 118,587, a partial agonist of beta 1-adrenoceptors, in mice, rats, rabbits, dogs, and humans by Marten, T R, Bourne, G R, Miles, G S, Shuker, B, Rankine, H D, Dutka, V N

“…The absorption, metabolism, and excretion of 14C-labeled xamoterol (ICI 118,587) has been examined in mice, rats, rabbits, dogs, and humans. There was…”
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The disposition of the synthetic prostaglandin analogue cloprostenol ('Estrumate') in the rat and marmoset by Bourne, G R, Moss, S R, Phillips, P J, Shuker, B

“…1. Following subcutaneous administration of the synthetic prostaglandin analogue [14C]cloprostenol to the rat (200 micrograms/kg), the dose was quantitatively…”
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The metabolic fate of the synthetic prostaglandin cloprostenol ('Estrumate') in the cow: use of ion cluster techniques to facilitate metabolite identification by Bourne, G R, Moss, S R, Phillips, P J, Shuker, B

“…The metabolic fate of the synthetic prostaglandin cloprostenol ('Estrumate') in the cow has been studied. Following intramuscular administration of 0.5 mg and…”
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Molecular Recognition in Methanol:  The First Example of Hydrogen-Bond-Mediated Self-Association of a Calix[4]arene in Polar, Protic Solvent by Brewster, R. Elizabeth, Shuker, Suzanne Beckham

“…Tetraalaninecalixarene was prepared by coupling of tetraaminocalix[4]arene with alanine. It dimerizes in methanol, providing the first example of a substituted…”
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Maxillofacial blast injuries by Shuker, Sabri T.

“…Blast injuries cause specific lesions and occur more often than previously, because of the wide use of explosives. This is especially the case in wartime. More…”
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