Search Results - "Shuhaibar, Leia C."
-
1
Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles
Published in Proceedings of the National Academy of Sciences - PNAS (28-04-2015)“…Meiosis in mammalian oocytes is paused until luteinizing hormone (LH) activates receptors in the mural granulosa cells of the ovarian follicle. Prior work has…”
Get full text
Journal Article -
2
Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor
Published in eLife (04-12-2017)“…Activating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 guanylyl cyclase both cause severe short stature, but…”
Get full text
Journal Article -
3
Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth
Published in JCI insight (10-05-2021)“…Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase…”
Get full text
Journal Article -
4
Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes
Published in Development (Cambridge) (01-09-2014)“…In mammals, the meiotic cell cycle of oocytes starts during embryogenesis and then pauses. Much later, in preparation for fertilization, oocytes within…”
Get full text
Journal Article -
5
Multiple cAMP Phosphodiesterases Act Together to Prevent Premature Oocyte Meiosis and Ovulation
Published in Endocrinology (Philadelphia) (01-05-2018)“…Luteinizing hormone (LH) acts on the granulosa cells that surround the oocyte in mammalian preovulatory follicles to cause meiotic resumption and ovulation…”
Get full text
Journal Article -
6
Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes
Published in Developmental biology (15-06-2012)“…In preovulatory ovarian follicles of mice, meiotic prophase arrest in the oocyte is maintained by cyclic GMP from the surrounding granulosa cells that diffuses…”
Get full text
Journal Article -
7
Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone
Published in Developmental biology (01-01-2016)“…The meiotic cell cycle of mammalian oocytes starts during embryogenesis and then pauses until luteinizing hormone (LH) acts on the granulosa cells of the…”
Get full text
Journal Article -
8
Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis
Published in Biology of reproduction (01-05-2016)“…The meiotic cell cycle of mammalian oocytes in preovulatory follicles is held in prophase arrest by diffusion of cGMP from the surrounding granulosa cells into…”
Get full text
Journal Article -
9
Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis1
Published in Biology of reproduction (01-05-2016)“…The meiotic cell cycle of mammalian oocytes in preovulatory follicles is held in prophase arrest by diffusion of cGMP from the surrounding granulosa cells into…”
Get full text
Journal Article -
10
Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase regulates oocyte meiotic resumption
Published in BMC pharmacology & toxicology (02-09-2015)Get full text
Journal Article -
11
Cyclic GMP-mediated intercellular communication in mammalian ovarian follicles
Published in BMC pharmacology & toxicology (29-08-2013)Get full text
Journal Article