Search Results - "Shuff, Sydney"
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Intense light-elicited alveolar type 2-specific circadian PER2 protects from bacterial lung injury via BPIFB1
Published in American journal of physiology. Lung cellular and molecular physiology (01-05-2022)“…Circadian amplitude enhancement has the potential to be organ protective but has not been studied in acute lung injury (ALI). Consistent light and dark cycles…”
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A Role for the Adenosine ADORA2B Receptor in Midazolam Induced Cognitive Dysfunction
Published in Current pharmaceutical design (01-01-2020)“…We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Based on previous studies showing a…”
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Intense light as anticoagulant therapy in humans
Published in PloS one (31-12-2020)“…Blood coagulation is central to myocardial ischemia and reperfusion (IR) injury. Studies on the light elicited circadian rhythm protein Period 2 (PER2) using…”
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RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells
Published in Nature cell biology (01-03-2018)“…For cancer cells to survive during extracellular matrix (ECM) detachment, they must inhibit anoikis and rectify metabolic deficiencies that cause non-apoptotic…”
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Chronic Lactate Exposure Decreases Mitochondrial Function by Inhibition of Fatty Acid Uptake and Cardiolipin Alterations in Neonatal Rat Cardiomyocytes
Published in Frontiers in nutrition (Lausanne) (04-03-2022)“…Lactate is an important signaling molecule with autocrine, paracrine and endocrine properties involved in multiple biological processes including regulation of…”
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The Role of Multicellular Aggregation in the Survival of ErbB2-positive Breast Cancer Cells during Extracellular Matrix Detachment
Published in The Journal of biological chemistry (03-04-2015)“…The metastasis of cancer cells from the site of the primary tumor to distant sites in the body represents the most deadly manifestation of cancer. In order for…”
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Linoleate-Enrichment of Mitochondrial Cardiolipin Molecular Species Is Developmentally Regulated and a Determinant of Metabolic Phenotype
Published in Biology (Basel, Switzerland) (24-12-2022)“…Cardiolipin (CL), the major mitochondrial phospholipid, regulates the activity of many mitochondrial membrane proteins. CL composition is shifted in heart…”
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Circadian Angiopoietin-Like-4 as a Novel Therapy in Cardiovascular Disease
Published in Trends in molecular medicine (01-07-2021)“…Angiopoietin-like 4 (ANGPTL4) is critical for regulating plasma lipids, and thus an attractive therapeutic target for cardiovascular diseases. Unfortunately,…”
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Abstract 1551: Succinyl-CoA synthetase Beta-A: A novel metastasis promoting factor in lung cancer
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Changes in metabolism occur when cancer cells disseminate from primary sites and metastasize. Mitochondrial metabolism plays an essential role in various…”
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Intense Light Pretreatment Improves Hemodynamics, Barrier Function and Inflammation in a Murine Model of Hemorrhagic Shock Lung
Published in Military medicine (18-09-2020)“…Abstract Introduction Hemorrhagic shock is a primary injury amongst combat casualties. Hemorrhagic shock can lead to acute lung injury, which has a high…”
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