Search Results - "Shudde, Claire"
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Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry
Published in Journal of immunological methods (01-07-2022)“…Immunotherapies for the treatment of cancer have spurred the development of new drugs that seek to harness the ability of T cells to recognize and kill…”
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Pegylated Liposomal Alendronate Biodistribution, Immune Modulation, and Tumor Growth Inhibition in a Murine Melanoma Model
Published in Biomolecules (Basel, Switzerland) (26-08-2023)“…While tumor-associated macrophages (TAM) have pro-tumoral activity, the ablation of macrophages in cancer may be undesirable since they also have anti-tumoral…”
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Uncovering the role of STAT5 in CD8+ T cell fate
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract Long-term protection against infection and disease requires long-lived memory CD8+ T cells. The development of these memory CD8+ T cells requires a…”
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A STAT5 activator protects CD8+ T cells in immunosuppressive environments
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract CD8+ T cells are central mediators of an anti-tumor immune response because they can recognize and kill cancerous cells. However, cancer can evade…”
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Repurposing amino-bisphosphonates by liposome formulation for a new role in cancer treatment
Published in Seminars in cancer biology (01-01-2021)“…Amino-bisphosphonates (N-BPs) have been commercially available for over four decades and are used for the treatment of osteoporosis, Paget’s disease,…”
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Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry
Published in The Journal of immunology (1950) (01-05-2022)“…Abstract Immunotherapies have transformed the treatment of cancer through the development of drugs that allow T cells to recognize and kill malignant cells…”
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An engineered viral protein rewires signaling pathways to overcome T cell suppression
Published in The Journal of immunology (1950) (01-05-2024)“…Abstract Cancer can evade destruction by depriving T cells of cytokines, such as IL-2, that cause JAK-STAT signaling required for T cell functionality. We…”
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