Search Results - "Shuangni Yu"

Expression of the immune checkpoint VISTA in breast cancer by Zong, Liju, Mo, Shengwei, Yu, Shuangni, Zhou, Yuncan, Zhang, Ming, Chen, Jie, Xiang, Yang

“…V-domain Ig suppressor of T cell activation (VISTA) is a novel immune checkpoint that is an emerging target for cancer immunotherapy. This study aimed to…”
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Analysis of the immune checkpoint V-domain Ig-containing suppressor of T-cell activation (VISTA) in endometrial cancer by Zong, Liju, Mo, Shengwei, Sun, Zezheng, Lu, Zhaohui, Yu, Shuangni, Chen, Jie, Xiang, Yang

“…V-domain Ig-containing suppressor of T-cell activation (VISTA) is a novel immune checkpoint protein and a potential immunotherapeutic target. However, its…”
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miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2 by Ma, Yihui, Yu, Shuangni, Zhao, Wugan, Lu, Zhaohui, Chen, Jie

“…Abstract MicroRNAs are short regulatory RNAs. A growing body of data implicates altered miRNA participate in the development of cancers and miR-27a is…”
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miRNA-96 Suppresses KRAS and Functions as a Tumor Suppressor Gene in Pancreatic Cancer by Yu, Shuangni, Lu, Zhaohui, Liu, Changzheng, Meng, Yunxiao, Ma, Yihui, Zhao, Wugan, Liu, Jianping, Yu, Jia, Chen, Jie

“…Therapeutic applications of microRNA (miRNA) in KRAS-driven pancreatic cancers might be valuable, but few studies have explored this area. Here, we report that…”
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Intratumoral neutrophil extracellular traps are associated with unfavorable clinical outcomes and immunogenic context in pancreatic ductal adenocarcinoma by Chen, Xianlong, Ma, Heng, Mo, Shengwei, Yu, Shuangni, Lu, Zhaohui, Chen, Jie

“…Extracellular traps (ETs) and tumor-infiltrating immune cells play crucial roles in tumor progression. However, little is known about the clinical significance…”
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Loss of ARID1A Expression Correlates With Tumor Differentiation and Tumor Progression Stage in Pancreatic Ductal Adenocarcinoma by Zhang, Li, Wang, Cuiping, Yu, Shuangni, Jia, Congwei, Yan, Jie, Lu, Zhaohui, Chen, Jie

“…Mutations in the AT-rich interactive domain 1A gene, which encodes a subunit of the Switch/Sucrose nonfermentable chromatin remodeling complex, can result in…”
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MiRNA-615-5p functions as a tumor suppressor in pancreatic ductal adenocarcinoma by targeting AKT2 by Sun, Yang, Zhang, Tingting, Wang, Cuiping, Jin, Xianglan, Jia, Congwei, Yu, Shuangni, Chen, Jie

“…Aberrant microRNA (miRNA) expression is associated with tumor development. This study aimed to elucidate the role of miR-615-5p in the development of…”
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Anti-PD-1 antibodies, a novel treatment option for advanced chemoresistant pulmonary lymphoepithelioma carcinoma by Zhou, Na, Tang, Hui, Yu, Shuangni, Lin, Yi, Wang, Yingyi, Wang, Yuzhou

“…Pulmonary lymphoepithelioma-like carcinoma (LELC) exhibits a unique immune microenvironment, including high PD-L1 expression and abundant infiltrating-immune…”
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MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma by Liu, Changzheng, Yu, Jia, Yu, Shuangni, Lavker, Robert M, Cai, Lei, Liu, Wei, Yang, Kegong, He, Xiaodong, Chen, Songsen

“…Background & Aims MicroRNA-21 negatively regulates several targets, thereby affecting tumorigenesis. However, its mechanism of action in human hepatocellular…”
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Analysis of the OX40/OX40L immunoregulatory axis combined with alternative immune checkpoint molecules in pancreatic ductal adenocarcinoma by Chen, Xianlong, Ma, Heng, Mo, Shengwei, Zhang, Yue, Lu, Zhaohui, Yu, Shuangni, Chen, Jie

“…Immune checkpoint modulation has been a vital therapeutic option in many malignancies, and targeting of novel immune checkpoints, including OX40/OX40L…”
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Expression of the immune targets in tumor-infiltrating immunocytes of gestational trophoblastic neoplasia by Cheng, Hongyan, Zong, Liju, Yu, Shuangni, Chen, Jie, Wan, Xirun, Xiang, Yang, Yang, Junjun

“…To evaluate the expression of emerging immune targets in the tumor-infiltrating immunocytes (TIIs) of human gestational trophoblastic neoplasia (GTN)…”
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Deregulation of the MiR-193b-KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer by Jin, Xianglan, Sun, Yang, Yang, Haiyan, Li, Ji, Yu, Shuangni, Chang, Xiaoyan, Lu, Zhaohui, Chen, Jie

“…Modulation of KRAS activity by upstream signals has revealed a promising new approach for pancreatic cancer therapy; however, it is not clear whether…”
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Expression and methylation status of MMR and MGMT in well-differentiated pancreatic neuroendocrine tumors and potential clinical applications by Ban, Xinchao, Mo, Shengwei, Lu, Zhaohui, Jia, Congwei, Shao, Huilin, Chang, Xiaoyan, Mao, Xinxin, Zhang, Yue, Pang, Junyi, Zhang, Yuhan, Yu, Shuangni, Chen, Jie

“…Purpose Recent studies claim that immune checkpoint inhibitors are effective in defective mismatch repair (dMMR) cancers. This raises the question of whether…”
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Genetic Alteration Profiles and Clinicopathological Associations in Atypical Parathyroid Adenoma by Mao, Xinxin, Wu, Yan, Yu, Shuangni, Chen, Jie

“…Genomic aberrations associated with atypical parathyroid adenoma (AA) are poorly understood. Thus, herein, we sought to expand our current understanding of the…”
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Correction to: Expression of the immune checkpoint VISTA in breast cancer by Zong, Liju, Mo, Shengwei, Yu, Shuangni, Zhou, Yuncan, Zhang, Ming, Chen, Jie, Xiang, Yang

“…The original version of this article unfortunately contained a mistake. The correct information is given below…”
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Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study by Yu, Shuangni, Sun, Zezheng, Zong, Liju, Yan, Jie, Yu, Mei, Chen, Jie, Lu, Zhaohui

“…The molecular classification system of endometrial carcinoma (EC) in 'The Cancer Genome Atlas' is widely acknowledged for its prognostic utility. Subsequently,…”
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Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix by Xiang, Yang, Chen, Jie, Yu, Shuangni, Kong, Yujia, Zhou, Yuncan, Zhang, Qianqian, Zong, Liju, Zhang, Youzhong

“…The purpose of this study was to investigate the expression levels of the immune checkpoint proteins, programmed cell death-ligand 1 (PD-L1), B7-H3, B7-H4, and…”
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Ezrin promotes invasion and metastasis of pancreatic cancer cells by Meng, Yunxiao, Lu, Zhaohui, Yu, Shuangni, Zhang, Qiang, Ma, Yihui, Chen, Jie

“…Pancreatic cancer has a high mortality rate because it is usually diagnosed when metastasis have already occurred (microscopic and gross disease). Ezrin plays…”
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Detection of POLE Subtypes in High-Grade Endometrioid Carcinoma by BaseScope-ISH Assay by Yu, Shuangni, Shao, Huilin, Ban, Xinchao, Zhang, Hongkai, You, Yan, Zhou, Na, Mao, Xinxin, Zhao, He, Chen, Jie, Lu, Zhaohui

“…Objective: The identification of DNA polymerase epsilon (POLE) mutation subtypes in endometrial cancer is critical for molecular classification. The mutation…”
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Analysis of a novel immune checkpoint, Siglec‐15, in pancreatic ductal adenocarcinoma by Chen, Xianlong, Mo, Shengwei, Zhang, Yue, Ma, Heng, Lu, Zhaohui, Yu, Shuangni, Chen, Jie

“…Siglec‐15, a novel immune checkpoint, is an emerging target for next‐generation cancer immunotherapy. However, the role of Siglec‐15 in pancreatic ductal…”
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