Search Results - "Shu, Lianhe"

Synthesis of a Spiroindolinone Pyrrolidinecarboxamide MDM2 Antagonist by Shu, Lianhe, Li, Zizhong, Gu, Chen, Fishlock, Dan

“…A practical synthesis of a spiroindolinone pyrrolidinecarboxamide MDM2 antagonist 2 is reported. Cycloaddition of dipolarophile 3 with imine 30 afforded a…”
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An N-Aryl-Substituted Oxazolidinone-Containing Ketone-Catalyzed Asymmetric Epoxidation with Hydrogen Peroxide as the Primary Oxidant by Burke, Christopher P, Shu, Lianhe, Shi, Yian

“…Asymmetric epoxidation of various olefins with an N-aryl-substituted oxazolidinone-containing ketone as catalyst and hydrogen peroxide as the primary oxidant…”
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An efficient ketone-catalyzed asymmetric epoxidation using hydrogen peroxide (H 2 O 2 ) as primary oxidant by Shu, Lianhe, Shi, Yian

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Effective Asymmetric Epoxidation of Styrenes by Chiral Dioxirane by Goeddel, David, Shu, Lianhe, Yuan, Yi, Wong, O. Andrea, Wang, Bin, Shi, Yian

“…High enantioselectivity (80−92% enantiomeric excess (ee)) has been obtained for the epoxidation of various styrenes using an easily prepared ketone (4)…”
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Asymmetric epoxidation using hydrogen peroxide (H 2O 2) as primary oxidant by Shu, Lianhe, Shi, Yian

“…High enantioselectivities have been obtained for asymmetric epoxidation of olefins using a fructose-derived chiral ketone as catalyst and hydrogen peroxide as…”
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An Efficient Ketone-Catalyzed Epoxidation Using Hydrogen Peroxide as Oxidant by Shu, Lianhe, Shi, Yian

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Designing New Chiral Ketone Catalysts. Asymmetric Epoxidation of cis-Olefins and Terminal Olefins by Tian, Hongqi, She, Xuegong, Yu, Hongwu, Shu, Lianhe, Shi, Yian

“…This paper describes a new class of chiral oxazolidinone ketone catalyst for asymmetric epoxidation. High ee values have been obtained for a number of cyclic…”
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Enantioselective Synthesis and Stereoselective Rearrangements of Enol Ester Epoxides by Zhu, Yuanming, Shu, Lianhe, Tu, Yong, Shi, Yian

“…Enol esters can be epoxidized with high enantioselectivities using the fructose-derived chiral ketone 1 as catalyst and Oxone as oxidant. A detailed study of…”
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An Improved Synthesis of a Ketone Catalyst for Asymmetric Epoxidation of Olefins by Shu, Lianhe, Shen, Yu-Mei, Burke, Christopher, Goeddel, David, Shi, Yian

“…An efficient synthesis of a ketone catalyst for asymmetric epoxidation of olefins from d-glucose in six steps is described…”
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Chiral Lewis Acid Catalyzed Resolution of Racemic Enol Ester Epoxides. Conversion of Both Enantiomers of an Enol Ester Epoxide to the Same Enantiomer of Acyloxy Ketone by Feng, Xiaoming, Shu, Lianhe, Shi, Yian

“…This paper describes an efficient kinetic resolution of racemic enol ester epoxides via a chiral Lewis acid catalyzed rearrangement. Both enantiomerically…”
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Practical Synthesis of MDM2 Antagonist RG7388. Part 1: A Cu(II)-Catalyzed Asymmetric [3 + 2] Cycloaddition by Shu, Lianhe, Gu, Chen, Fishlock, Dan, Li, Zizhong

“…An efficient asymmetric synthesis of MDM2 antagonist RG7388 is reported. The highly functionalized chiral pyrrolidine carboxamide was assembled via a…”
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Synthesis of Enantiopure Fmoc-α-Methylvaline by Shu, Lianhe, Wang, Ping

“…An efficient synthesis of enantiopure Fmoc-α-methylvaline has been developed. The racemate was prepared in two steps from 3-methyl-2-butanone and was resolved…”
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Efficient Large-Scale Synthesis of a 2,4,5-Triarylimidazoline MDM2 Antagonist by Shu, Lianhe, Gu, Chen, Dong, Yan, Brinkman, Robert

“…An improved, kilogram-scale synthesis of a triarylimidazoline MDM2 antagonist is reported. The nicotinic acid component was prepared in three steps from ethyl…”
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A Practical Synthesis of a cis-4,5-Bis(4-chlorophenyl)imidazoline Intermediate for Nutlin Analogues by Shu, Lianhe, Wang, Ping, Liu, Wen, Gu, Chen

“…A practical synthesis of cis-4,5-bis(4-chlorophenyl)imidazoline, a key intermediate for Nutlin analogues, is reported. The title compound was prepared in…”
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Chemistry of C84: Separation of Three Constitutional Isomers and Optical Resolution ofD2-C84 by Using the “Bingel-Retro-Bingel” Strategy by Crassous, Jeanne, Rivera, José, Fender, Nicolette S., Shu, Lianhe, Echegoyen, Luis, Thilgen, Carlo, Herrmann, Andreas, Diederich, François

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Process Research on a Phenoxybutyric Acid LTB4 Receptor Antagonist. Efficient Kilogram-Scale Synthesis of a 3,5-Bisarylphenol Core by Shu, Lianhe, Wang, Ping, Radinov, Roumen, Dominique, Romyr, Wright, James, Alabanza, Lady Mae, Dong, Yan

“…An improved, kilogram-scale synthesis of a LTB4 receptor antagonist is reported. The title compound was prepared in four linear steps (seven steps total) and…”
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An Efficient Large-Scale Synthesis of a Naphthylacetic Acid CRTH2 Receptor Antagonist by Shu, Lianhe, Wang, Ping, Gu, Chen, Liu, Wen, Alabanza, Lady Mae, Zhang, Yingchao

“…An efficient and practical synthesis of a naphthylacetic acid CRTH2 receptor antagonist is reported. Michael addition of ethyl t-butyl malonate to an allenoate…”
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Asymmetric epoxidation of cis-β-methylstyrenes catalyzed by N-aryl substituted oxazolidinone-containing ketones. A beneficial substituent effect by Shu, Lianhe, Shi, Yian

“…[Display omitted] Asymmetric epoxidation of substituted cis-β-methylstyrenes using N-aryl substituted oxazolidinone-containing ketones as catalysts shows that…”
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A Concise Synthesis of a Tetrahydropyrazolopyrazine Building Block by Shu, Lianhe, Wang, Ping, Gu, Chen, Garofalo, Lisa, Alabanza, Lady Mae, Dong, Yan

“…A concise synthesis of a tetrahydropyrazolopyrazine building block is described. 5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamine was prepared in…”
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Convenient Synthesis of 5,7-Dichlorothiazolo[5,4-d]pyrimidine by Shu, Lianhe, Mae Alabanza, Lady, Gu, Chen

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