Search Results - "Shtiegman, Keren"

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation by Mosesson, Yaron, Shtiegman, Keren, Katz, Menachem, Zwang, Yaara, Vereb, Gyorgi, Szollosi, Janos, Yarden, Yosef

“…Growth factors stimulate specific receptor tyrosine kinases, but subsequent receptor endocytosis terminates signaling. The ubiquitin ligase c-Cbl targets…”
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Conjugation to Nedd8 Instigates Ubiquitylation and Down-regulation of Activated Receptor Tyrosine Kinases by Oved, Shlomo, Mosesson, Yaron, Zwang, Yaara, Santonico, Elena, Shtiegman, Keren, Marmor, Mina D., Kochupurakkal, Bose S., Katz, Menachem, Lavi, Sara, Cesareni, Gianni, Yarden, Yosef

“…When appended to the epidermal growth factor receptor (EGFR), ubiquitin serves as a sorting signal for lysosomal degradation. Here we demonstrate that the…”
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A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling by Waterman, Hadassa, Katz, Menachem, Rubin, Chanan, Shtiegman, Keren, Lavi, Sara, Elson, Ari, Jovin, Thomas, Yarden, Yosef

“…Ligand‐induced desensitization of the epidermal growth factor receptor (EGFR) is controlled by c‐Cbl, a ubiquitin ligase that binds multiple signaling…”
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Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding by Amit, Ido, Yakir, Liat, Katz, Menachem, Zwang, Yaara, Marmor, Mina D, Citri, Ami, Shtiegman, Keren, Alroy, Iris, Tuvia, Shmuel, Reiss, Yuval, Roubini, Eli, Cohen, Maya, Wides, Ron, Bacharach, Eran, Schubert, Ullrich, Yarden, Yosef

“…The tumor suppressor gene 101 (tsg101) regulates vesicular trafficking processes in yeast and mammals. We report a novel protein, Tal (Tsg101-associated…”
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The role of ubiquitylation in signaling by growth factors: implications to cancer by Shtiegman, Keren, Yarden, Yosef

“…Cancer cells depend on multiple, locally produced growth factors. Signaling by growth factors entails phosphorylation events, and its termination is determined…”
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Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4 by Katz, Menachem, Shtiegman, Keren, Tal‐Or, Pazit, Yakir, Liat, Mosesson, Yaron, Harari, Daniel, Machluf, Yossi, Asao, Hironobu, Jovin, Thomas, Sugamura, Kazuo, Yarden, Yosef

“…Ligand‐dependent endocytosis of the epidermal growth factor receptor (EGFR) involves recruitment of a ubiquitin ligase, and sorting of ubiquitylated receptors…”
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The role of ubiquitylation in signaling by growth factors: implications to cancer: Protein degradation in tumour development by SHTIEGMAN, Keren, YARDEN, Yosef

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Voluntary Ethanol Consumption in Male Adolescent Hamsters Increases Testosterone and Aggression by Ferris, Craig F, Shtiegman, Keren, King, Jean A

“…The immediate and long-term biologic and behavioral consequences of voluntary ethanol (EtOH) exposure during male adolescence are unknown. In the present…”
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