Search Results - "Shroyer, Kenneth"

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth by Montal, Emily D., Dewi, Ruby, Bhalla, Kavita, Ou, Lihui, Hwang, Bor Jang, Ropell, Ashley E., Gordon, Chris, Liu, Wan-Ju, DeBerardinis, Ralph J., Sudderth, Jessica, Twaddel, William, Boros, Laszlo G., Shroyer, Kenneth R., Duraisamy, Sekhar, Drapkin, Ronny, Powers, R. Scott, Rohde, Jason M., Boxer, Matthew B., Wong, Kwok-Kin, Girnun, Geoffrey D.

“…Phosphoenolpyruvate carboxykinase (PEPCK) is well known for its role in gluconeogenesis. However, PEPCK is also a key regulator of TCA cycle flux. The TCA…”
Get full text

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference by Premsrirut, Prem K., Dow, Lukas E., Kim, Sang Yong, Camiolo, Matthew, Malone, Colin D., Miething, Cornelius, Scuoppo, Claudio, Zuber, Johannes, Dickins, Ross A., Kogan, Scott C., Shroyer, Kenneth R., Sordella, Raffaella, Hannon, Gregory J., Lowe, Scott W.

“…RNA interference is a powerful tool for studying gene function, however, the reproducible generation of RNAi transgenic mice remains a significant limitation…”
Get full text

Prognostic significance of miR-205 in endometrial cancer by Karaayvaz, Mihriban, Zhang, Cecilia, Liang, Sharon, Shroyer, Kenneth R, Ju, Jingfang

“…microRNAs have emerged as key regulators of gene expression, and their altered expression has been associated with tumorigenesis and tumor progression. Thus,…”
Get full text

miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14 by Li, Yiyi, Kuscu, Cem, Banach, Anna, Zhang, Qian, Pulkoski-Gross, Ashleigh, Kim, Deborah, Liu, Jingxuan, Roth, Eric, Li, Ellen, Shroyer, Kenneth R, Denoya, Paula I, Zhu, Xiaoxia, Chen, Longhua, Cao, Jian

“…Upregulation of matrix metalloproteinase MMP-14 (MT1-MMP) is associated with poor prognosis in cancer patients, but it is unclear how MMP-14 becomes elevated…”
Get full text

Dose ranging, expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nanoparticle formulations by Kanakia, Shruti, Toussaint, Jimmy D, Mullick Chowdhury, Sayan, Tembulkar, Tanuf, Lee, Stephen, Jiang, Ya-Ping, Lin, Richard Z, Shroyer, Kenneth R, Moore, William, Sitharaman, Balaji

“…Abstract Graphene nanoparticle dispersions show immense potential as multifunctional agents for in vivo biomedical applications. Herein, we follow regulatory…”
Get full text

Dissecting the Oncogenic Roles of Keratin 17 in the Hallmarks of Cancer by Baraks, Gabriella, Tseng, Robert, Pan, Chun-Hao, Kasliwal, Saumya, Leiton, Cindy V, Shroyer, Kenneth R, Escobar-Hoyos, Luisa F

“…There is an unmet need to identify and validate tumor-specific therapeutic targets to enable more effective treatments for cancer. Heterogeneity in patient…”
Get full text

Dry heat sterilization as a method to recycle N95 respirator masks: The importance of fit by Yuen, John G, Marshilok, Amy C, Benziger, Peter Todd, Yan, Shan, Cello, Jeronimo, Stackhouse, Chavis A, Kisslinger, Kim, Bock, David C, Takeuchi, Esther S, Takeuchi, Kenneth J, Wang, Lei, Babu, Sruthi, Itzkowitz, Glen, Thanassi, David, Knopf, Daniel A, Shroyer, Kenneth R

“…In times of crisis, including the current COVID-19 pandemic, the supply chain of filtering facepiece respirators, such as N95 respirators, are disrupted. To…”
Get full text

Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders by Gaudino, Stephen J., Singh, Ankita, Huang, Huakang, Padiadpu, Jyothi, Jean-Pierre, Makheni, Kempen, Cody, Bahadur, Tej, Shiomitsu, Kiyoshi, Blumberg, Richard, Shroyer, Kenneth R., Beyaz, Semir, Shulzhenko, Natalia, Morgun, Andrey, Kumar, Pawan

“…IL-22 is critical for ameliorating obesity-induced metabolic disorders. However, it is unknown where IL-22 acts to mediate these outcomes. Here we examine the…”
Get full text

Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet by Luo, Yongde, Yang, Yaying, Liu, Muyun, Wang, Dan, Wang, Feng, Bi, Yawei, Ji, Juntao, Li, Suyun, Liu, Yan, Chen, Rong, Huang, Haojie, Wang, Xiaojie, Swidnicka-Siergiejko, Agnieszka K., Janowitz, Tobias, Beyaz, Semir, Wang, Guoqiang, Xu, Sulan, Bialkowska, Agnieszka B., Luo, Catherine K., Pin, Christoph L., Liang, Guang, Lu, Xiongbin, Wu, Maoxin, Shroyer, Kenneth R., Wolff, Robert A., Plunkett, William, Ji, Baoan, Li, Zhaoshen, Li, Ellen, Li, Xiaokun, Yang, Vincent W., Logsdon, Craig D., Abbruzzese, James L., Lu, Weiqin

“…Obesity is a risk factor for pancreatic cancer. In mice, a high-fat diet (HFD) and expression of oncogenic KRAS lead to development of invasive pancreatic…”
Get full text

Development of Patient-Derived Gastric Cancer Organoids from Endoscopic Biopsies and Surgical Tissues by Gao, Mei, Lin, Miranda, Rao, Manisha, Thompson, Hannah, Hirai, Kelsi, Choi, Minsig, Georgakis, Georgios V., Sasson, Aaron R., Bucobo, Juan Carlos, Tzimas, Demetri, D’Souza, Lionel S., Buscaglia, Jonathan M., Davis, James, Shroyer, Kenneth R., Li, Jinyu, Powers, Scott, Kim, Joseph

“…Background Organoids are three-dimensional in vitro models of human disease developed from benign and malignant gastrointestinal tissues with tremendous…”
Get full text

Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility by Escobar-Hoyos, Luisa F, Shah, Ruchi, Roa-Peña, Lucia, Vanner, Elizabeth A, Najafian, Nilofar, Banach, Anna, Nielsen, Erik, Al-Khalil, Ramsey, Akalin, Ali, Talmage, David, Shroyer, Kenneth R

“…Keratins that are overexpressed selectively in human carcinomas may offer diagnostic and prognostic utility. In this study, we show that high expression of…”
Get full text

Intratumoral Budding and Tumor Microenvironment in Pretreatment Rectal Cancer Biopsies Predict the Response to Neoadjuvant Chemoradiotherapy by Wen, Xiaoyun, Zee, Sui Y., Shroyer, Kenneth R., Bandovic, Jela

“…Tumor budding at the invasive tumor front (peritumoral budding) is an established prognostic factor in colorectal cancer. However, the significance of…”
Get full text

Hexavalent chromium exposure activates the non-canonical nuclear factor kappa B pathway to promote immune checkpoint protein programmed death-ligand 1 expression and lung carcinogenesis by Wang, Po-Shun, Liu, Zulong, Sweef, Osama, Saeed, Abdullah Farhan, Kluz, Thomas, Costa, Max, Shroyer, Kenneth R., Kondo, Kazuya, Wang, Zhishan, Yang, Chengfeng

“…Lung cancer is the leading cause of cancer-related death worldwide; however, the mechanism of lung carcinogenesis has not been clearly defined. Chronic…”
Get full text

Keratin 17 Is a Novel Cytologic Biomarker for Urothelial Carcinoma Diagnosis by Babu, Sruthi, Kim, Nam W, Wu, Maoxin, Chan, Ina, Escobar-Hoyos, Luisa F, Shroyer, Kenneth R

“…Abstract Objectives The microscopic features of urine cytology specimens are subjective and may not reliably distinguish between benign urothelial cells and…”
Get full text

Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker by Escobar-Hoyos, Luisa F, Yang, Jie, Zhu, Jiawen, Cavallo, Julie-Ann, Zhai, Haiyan, Burke, Stephanie, Koller, Antonius, Chen, Emily I, Shroyer, Kenneth R

“…Most previously described immunohistochemical markers of cervical high-grade squamous intraepithelial lesion (HSIL) and squamous cell carcinoma may help to…”
Get full text

Keratin 17 identifies the most lethal molecular subtype of pancreatic cancer by Roa-Peña, Lucia, Leiton, Cindy V., Babu, Sruthi, Pan, Chun-Hao, Vanner, Elizabeth A., Akalin, Ali, Bandovic, Jela, Moffitt, Richard A., Shroyer, Kenneth R., Escobar-Hoyos, Luisa F.

“…Although the overall five-year survival of patients with pancreatic ductal adenocarcinoma (PDAC) is dismal, there are survival differences between cases with…”
Get full text

Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium-specific Deletion of Klf4 by Yang, Vincent W, Liu, Yang, Kim, Julie, Shroyer, Kenneth R, Bialkowska, Agnieszka B

“…Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, regulates homeostasis of the intestinal epithelium. Previously, it was reported that KLF4…”
Get full text

Annexin A2 promotes glioma cell invasion and tumor progression by Zhai, Haiyan, Acharya, Suchitra, Gravanis, Iordanis, Mehmood, Saira, Seidman, Roberta J, Shroyer, Kenneth R, Hajjar, Katherine A, Tsirka, Stella E

“…Gliomas are highly invasive, lethal brain tumors. Tumor-associated proteases play an important role in glioma progression. Annexin A2 is overexpressed in many…”
Get full text

Deep learning-based image analysis methods for brightfield-acquired multiplex immunohistochemistry images by Fassler, Danielle J, Abousamra, Shahira, Gupta, Rajarsi, Chen, Chao, Zhao, Maozheng, Paredes, David, Batool, Syeda Areeha, Knudsen, Beatrice S, Escobar-Hoyos, Luisa, Shroyer, Kenneth R, Samaras, Dimitris, Kurc, Tahsin, Saltz, Joel

“…Multiplex immunohistochemistry (mIHC) permits the labeling of six or more distinct cell types within a single histologic tissue section. The classification of…”
Get full text

Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma by Pagnotti, Gabriel M., Chan, M. Ete, Adler, Benjamin J., Shroyer, Kenneth R., Rubin, Janet, Bain, Steven D., Rubin, Clinton T.

“…Myeloma facilitates destruction of bone and marrow. Since physical activity encourages musculoskeletal preservation we evaluated whether low-intensity…”
Get full text