Towards a Portable Platform Integrated With Multispectral Noncontact Probes for Delineating Normal and Breast Cancer Tissue Based on Near-Infrared Spectroscopy

Towards a Portable Platform Integrated With Multispectral Noncontact Probes for Delineating Normal and Breast Cancer Tissue Based on Near-Infrared Spectroscopy

Currently, the confirmation of diagnosis of breast cancer is made by microscopic examination of an ultra-thin slice of a needle biopsy specimen. This slice is conventionally formalin-fixed and stained with hematoxylin-eosin and visually examined under a light microscope. This process is labor-intens...

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Bibliographic Details
Published in:IEEE transactions on biomedical circuits and systems Vol. 14; no. 4; pp. 879 - 888
Main Authors: Pal, Uttam M., GK, Anil Vishnu, Gogoi, Gayatri, Rila, Saeed, Shroff, Saahil, AM, Gokul, Borah, Pronami, Varma, Manoj, Kurpad, Vishnu, Baruah, Deb, Vaidya, Jayant S., Pandya, Hardik J.
Format: Journal Article
Language:English
Published: United States IEEE 01-08-2020
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:
Absorption
Absorption spectroscopy
Biopsy
Biopsy - instrumentation
Biopsy - methods
Biopsy tissue
Breast - chemistry
Breast - pathology
Breast cancer
Breast Neoplasms - chemistry
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Collagen
Collagen - chemistry
collagens
Diagnosis
Diagnostic systems
Equipment Design
Female
Histocytochemistry
Humans
I.R. radiation
Infrared spectra
Infrared spectroscopy
Lipidomics
Lipids
Lipids - chemistry
Near infrared radiation
near-infrared spectroscopy
non-invasive
Spectroscopy
Spectroscopy, Near-Infrared - instrumentation
Spectroscopy, Near-Infrared - methods
Spectrum analysis
Statistical analysis
Statistical methods
Tissues
Wavelengths
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Summary:Currently, the confirmation of diagnosis of breast cancer is made by microscopic examination of an ultra-thin slice of a needle biopsy specimen. This slice is conventionally formalin-fixed and stained with hematoxylin-eosin and visually examined under a light microscope. This process is labor-intensive and requires highly skilled doctors (pathologists). In this paper, we report a novel tool based on near-infrared spectroscopy (Spectral-IRDx) which is a portable, non-contact, and cost-effective system and could provide a rapid and accurate diagnosis of cancer. The Spectral-IRDx tool performs absorption spectroscopy at near-infrared (NIR) wavelengths of 850, 935, and 1060 nm. We measure normalized detected voltage (V dn ) with the tool in 10 deparaffinized breast biopsy tissue samples, 5 of which were cancer (C) and 5 were normal (N) tissues. The difference in V dn at 935 nm and 1060 nm between cancer and normal tissues is statistically significant with p -values of 0.0038 and 0.0022 respectively. Absorption contrast factor (N/C) of 1.303, 1.551, and 1.45 are observed for 850, 935, and 1060 nm respectively. The volume fraction contrast (N/C) of lipids and collagens are reported as 1.28 and 1.10 respectively. Higher absorption contrast factor (N/C) and volume fraction contrast (N/C) signifies higher concentration of lipids in normal tissues as compared to cancerous tissues, a basis for delineation. These preliminary results support the envisioned concept for noninvasive and noncarcinogenic NIR-based breast cancer diagnostic platform, which will be tested using a larger number of samples.
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ISSN:1932-4545
1940-9990
DOI:10.1109/TBCAS.2020.3005971