Search Results - "Shrive, Nigel"

Dexamethasone inhibits inflammation and cartilage damage in a new model of post-traumatic osteoarthritis by Huebner, Kyla D., Shrive, Nigel G., Frank, Cyril B.

“…ABSTRACT Corticosteroids are used in musculoskeletal diseases, and offer patient relief. Injections of corticosteroids are recommended for management of…”
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Homo sapiens May Incorporate Daily Acute Cycles of “Conditioning–Deconditioning” to Maintain Musculoskeletal Integrity: Need to Integrate with Biological Clocks and Circadian Rhythm Mediators by Hart, David A., Zernicke, Ronald F., Shrive, Nigel G.

“…Human evolution required adaptation to the boundary conditions of Earth, including 1 g gravity. The bipedal mobility of Homo sapiens in that gravitational…”
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The instrumented sheep knee to elucidate insights into osteoarthritis development and progression: A sensitive and reproducible platform for integrated research efforts by Hart, David A., Martin, C. Ryan, Scott, Michael, Shrive, Nigel G.

“…Osteoarthritis of the knee is a very common condition that has been difficult to treat. The majority of cases are considered idiopathic. Much research effort…”
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Single intra-articular dexamethasone injection immediately post-surgery in a rabbit model mitigates early inflammatory responses and post-traumatic osteoarthritis-like alterations by Heard, Bryan J., Barton, Kristen I., Chung, May, Achari, Yamini, Shrive, Nigel G., Frank, Cyril B., Hart, David A.

“…ABSTRACT Despite surgical reconstruction of the anterior cruciate ligament, a significant number of patients will still develop post‐traumatic osteoarthritis…”
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Partially grouted concrete masonry shear walls subject to in-plane shear load: a critical review by Zhu, Jianyixian, Shrive, Nigel

“…Although structures have been built from masonry for many years, little is still known about the behaviour of a wall subject to in-plane shear. This is…”
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Shear load capacity prediction of unperforated and perforated partially grouted masonry walls by Medeiros, Klaus A.S., Parsekian, Guilherme A., Shrive, Nigel G., Fonseca, Fernando S.

“…•Use of a robust database comprising numerical and experimental specimens.•Different existing shear equations are evaluated.•Current design codes predict…”
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In-plane behavior and seismic performance of differently detailed, multi-story, perforated, partially grouted masonry walls by Medeiros, Klaus A.S., Palhares, Rodolfo A., Parsekian, Guilherme A., Shrive, Nigel G., Fonseca, Fernando S.

“…•Use of experimental tests and a precise finite element model;•Assessment of bilinear and trilinear idealizations for the actual wall response;•Walls…”
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Measuring the Internal Stress in Ovine Meniscus During Simulated In Vivo Gait Kinematics: A Novel Method Using Fibre Optic Technology by Vakiel, Paris, Dennison, Christopher R., Shekarforoush, Mehdi, Scott, Michael, Hart, David A., Shrive, Nigel G.

“…Changes in stress transferred across articular joints have been described as a substantial factor in the initiation and progression of joint disease such as…”
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Correlation between translational and rotational kinematic abnormalities and osteoarthritis-like damage in two in vivo sheep injury models by Shekarforoush, Mehdi, Beveridge, Jillian E., Hart, David A., Frank, Cyril B., Shrive, Nigel G.

“…The relations between kinematic abnormalities and post traumatic osteoarthritis have not yet been clearly elucidated. This study was conducted to determine the…”
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Current concepts on structure-function relationships in the menisci by Andrews, Stephen H J, Adesida, Adetola B, Abusara, Ziad, Shrive, Nigel G

“…The menisci are intricately organized structures that perform many tasks in the knee. We review their structure and function and introduce new data about their…”
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Stress Measurements on the Articular Cartilage Surface Using Fiber Optic Technology and In-Vivo Gait Kinematics by Vakiel, Paris, Shekarforoush, Mehdi, Dennison, Christopher R., Scott, Michael, Frank, Cyril B., Hart, David A., Shrive, Nigel G.

“…It has been hypothesized a change in stress on the cartilage of a joint is a significant factor in the initiation and progression of post-traumatic…”
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Relative Surface Velocity of the Tibiofemoral Joint and Its Relation to the Development of Osteoarthritis After Joint Injury by Shekarforoush, Mehdi, Vakiel, Paris, Scott, Michael, Muench, Gregory, Hart, David A., Shrive, Nigel G.

“…The relative velocity of the tibiofemoral surfaces during gait before and after partial-ACL and full MCL transection (p-ACL/MCL Tx) was examined in an ovine…”
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Mapping Stresses on the Tibial Plateau Cartilage in an Ovine Model Using In-Vivo Gait Kinematics by Vakiel, Paris, Shekarforoush, Mehdi, Dennison, Christopher R., Scott, Michael, Muench, Gregory, Hart, David A., Shrive, Nigel G.

“…Understanding stresses within the knee joint is central to understanding knee function, and the etiology and progression of degenerative joint diseases such as…”
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Tie‐fibre structure and organization in the knee menisci by Andrews, Stephen H. J., Rattner, Jerome B., Abusara, Ziad, Adesida, Adetola, Shrive, Nigel G., Ronsky, Janet L.

“…The collagenous structure of the knee menisci is integral to the mechanical integrity of the tissue and the knee joint. The tie‐fibre structure of the tissue…”
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Numerical analysis of eco-friendly ductile cementitious composite influence on structural masonry reinforcement by Veronese, Renato B.A., Medeiros, Wallison A., Parsekian, Guilherme A., Shrive, Nigel G.

“…•EDCC-coated masonry compressive, flexural and shear tests are simulated in ABAQUS.•Parameters for correctly masonry Finite Element Modelling are validated.•A…”
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Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis by Mickiewicz, Beata, Heard, Bryan J., Chau, Johnny K., Chung, May, Hart, David A., Shrive, Nigel G., Frank, Cyril B., Vogel, Hans J.

“…ABSTRACT Joint injuries and subsequent osteoarthritis (OA) are the leading causes of chronic joint disease. In this work, we explore the possibility of…”
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Uncertainty analysis of the effect of grout injection on the deformation of multi-wythe stone masonry walls by Isfeld, Andrea C., Moradabadi, Ehsan, Laefer, Debra F., Shrive, Nigel G.

“…•Stone masonry walls modelled using random field finite element micro-modelling.•Grout injection studied using randomized material properties for the stone and…”
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Methylprednisolone acetate mitigates IL1β induced changes in matrix metalloproteinase gene expression in skeletally immature ovine explant knee tissues by Barton, Kristen I., Chung, May, Frank, Cyril B., Shrive, Nigel G., Hart, David A.

“…Objective and design This study aimed at evaluating the effect of methylprednisolone (MPA) on messenger ribonucleic acid (mRNA) expression levels in immature…”
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Heterotopic mineralization (ossification or calcification) in tendinopathy or following surgical tendon trauma by O'Brien, Etienne J. O., Frank, Cyril B., Shrive, Nigel G., Hallgrímsson, Benedikt, Hart, David A.

“…Summary Heterotopic tendon mineralization (ossification or calcification), which may be a feature of tendinopathy or which may develop following surgical…”
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Perspective: Challenges Presented for Regeneration of Heterogeneous Musculoskeletal Tissues that Normally Develop in Unique Biomechanical Environments by Hart, David A., Nakamura, Norimasa, Shrive, Nigel G.

“…Perspective: Musculoskeletal (MSK) tissues such as articular cartilage, menisci, tendons, and ligaments are often injured throughout life as a consequence of…”
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