Search Results - "Shrestha, Sanjib K"

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents by Chandrika, Nishad Thamban, Shrestha, Sanjib K., Ngo, Huy X., Garneau-Tsodikova, Sylvie

“…[Display omitted] The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal strains have resulted in an increase in demand for new…”
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Activation and Loading of the Starter Unit during Thiocoraline Biosynthesis by Mori, Shogo, Shrestha, Sanjib K, Fernández, Javier, Álvarez San Millán, María, Garzan, Atefeh, Al-Mestarihi, Ahmad H, Lombó, Felipe, Garneau-Tsodikova, Sylvie

“…The initiation of the nonribosomal peptide synthetase (NRPS) assembly of the bisintercalator natural product thiocoraline involves key enzymatic steps for AMP…”
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Differential Effects of Linkers on the Activity of Amphiphilic Tobramycin Antifungals by Fosso, Marina Y, Shrestha, Sanjib K, Thamban Chandrika, Nishad, Dennis, Emily K, Green, Keith D, Garneau-Tsodikova, Sylvie

“…As the threat associated with fungal infections continues to rise and the availability of antifungal drugs remains a concern, it becomes obvious that the need…”
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Antifungal amphiphilic aminoglycoside K20: bioactivities and mechanism of action by Shrestha, Sanjib K, Chang, Cheng-Wei T, Meissner, Nicole, Oblad, John, Shrestha, Jaya P, Sorensen, Kevin N, Grilley, Michelle M, Takemoto, Jon Y

“…K20 is a novel amphiphilic antifungal aminoglycoside that is synthetically derived from the antibiotic kanamycin A. Reported here are investigations of K20's…”
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Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall by Louzoun Zada, Sivan, Green, Keith D, Shrestha, Sanjib K, Herzog, Ido M, Garneau-Tsodikova, Sylvie, Fridman, Micha

“…Here, we describe the preparation and evaluation of α,β-unsaturated carbonyl derivatives of the bacterial translation inhibiting antibiotic chloramphenicol…”
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Novel alkylated azoles as potent antifungals by Shrestha, Sanjib K., Garzan, Atefeh, Garneau-Tsodikova, Sylvie

“…Fluconazole (FLC) is the drug of choice when it comes to treat fungal infections such as invasive candidiasis in humans. However, the widespread use of FLC has…”
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A combination approach to treating fungal infections by Shrestha, Sanjib K., Fosso, Marina Y., Garneau-Tsodikova, Sylvie

“…Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance,…”
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Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents by Thamban Chandrika, Nishad, Shrestha, Sanjib K, Ngo, Huy X, Tsodikov, Oleg V, Howard, Kaitlind C, Garneau-Tsodikova, Sylvie

“…The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in…”
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Synthesis and Bioactivities of Kanamycin B‑Derived Cationic Amphiphiles by Fosso, Marina Y, Shrestha, Sanjib K, Green, Keith D, Garneau-Tsodikova, Sylvie

“…Cationic amphiphiles derived from aminoglycosides (AGs) have been shown to exhibit enhanced antimicrobial activity. Through the attachment of hydrophobic…”
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Amphiphilic Tobramycin Analogues as Antibacterial and Antifungal Agents by Shrestha, Sanjib K, Fosso, Marina Y, Green, Keith D, Garneau-Tsodikova, Sylvie

“…In this study, we investigated the in vitro antifungal activities, cytotoxicities, and membrane-disruptive actions of amphiphilic tobramycin (TOB) analogues…”
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Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and bromperidol derivatives in the treatment of various fungal infections by Holbrook, Selina Y.L., Garzan, Atefeh, Dennis, Emily K., Shrestha, Sanjib K., Garneau-Tsodikova, Sylvie

“…As the number of hospitalized and immunocompromised patients continues to rise, invasive fungal infections, such as invasive candidiasis and aspergillosis,…”
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Novel fluconazole derivatives with promising antifungal activity by Thamban Chandrika, Nishad, Shrestha, Sanjib K., Ngo, Huy X., Howard, Kaitlind C., Garneau-Tsodikova, Sylvie

“…[Display omitted] The fungistatic nature and toxicity concern associated with the azole drugs currently on the market have resulted in an increased demand for…”
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Expanding Substrate Promiscuity by Engineering a Novel Adenylating-Methylating NRPS Bifunctional Enzyme by Shrestha, Sanjib K., Garneau-Tsodikova, Sylvie

“…Nonribosomal peptides synthetases (NRPSs), which are multifunctional mega‐enzymes producing many biologically active metabolites, are ideal targets for enzyme…”
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Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity by Ngo, Huy X., Shrestha, Sanjib K., Garneau-Tsodikova, Sylvie

“…Invasive fungal infections are on the rise due to an increased population of critically ill patients as a result of HIV infections, chemotherapies, and organ…”
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Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus by Ngo, Huy X., Shrestha, Sanjib K., Green, Keith D., Garneau-Tsodikova, Sylvie

“…[Display omitted] Antibiotic resistance is a worldwide problem that needs to be addressed. Staphylococcus aureus is one of the dangerous “ESKAPE” pathogens…”
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Structure–Activity Relationships for Antibacterial to Antifungal Conversion of Kanamycin to Amphiphilic Analogues by Fosso, Marina, AlFindee, Madher N, Zhang, Qian, Nziko, Vincent de Paul Nzuwah, Kawasaki, Yukie, Shrestha, Sanjib K, Bearss, Jeremiah, Gregory, Rylee, Takemoto, Jon Y, Chang, Cheng-Wei Tom

“…Novel fungicides are urgently needed. It was recently reported that the attachment of an octyl group at the O-4″ position of kanamycin B converts this…”
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N,N′-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents by Thamban Chandrika, Nishad, Dennis, Emily K., Shrestha, Sanjib K., Ngo, Huy X., Green, Keith D., Kwiatkowski, Stefan, Deaciuc, Agripina Gabriela, Dwoskin, Linda P., Watt, David S., Garneau-Tsodikova, Sylvie

“…N,N′-Diaryl-bishydrazones of [1,1′-biphenyl]-3,4′-dicarboxaldehyde, [1,1′-biphenyl]-4,4′-dicarboxaldehyde, and 4,4′-bisacetyl-1,1-biphenyl exhibited excellent…”
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New Application of Neomycin B–Bisbenzimidazole Hybrids as Antifungal Agents by Thamban Chandrika, Nishad, Shrestha, Sanjib K, Ranjan, Nihar, Sharma, Anindra, Arya, Dev P, Garneau-Tsodikova, Sylvie

“…Alkylated aminoglycosides and bisbenzimidazoles have previously been shown to individually display antifungal activity. Herein, we explore for the first time…”
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In vitro antifungal synergy between amphiphilic aminoglycoside K20 and azoles against Candida species and Cryptococcus neoformans by Shrestha, Sanjib K., Grilley, Michelle, Anderson, Thomas, Dhiman, Christine, Oblad, John, Chang, Cheng-Wei T., Sorensen, Kevin N., Takemoto, Jon Y.

“…Several azoles are widely used to treat human fungal infections. Increasing resistance to these azoles has prompted exploration of their synergistic antifungal…”
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Back Cover: Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity (ChemMedChem 14/2016) by Ngo, Huy X., Shrestha, Sanjib K., Garneau-Tsodikova, Sylvie

“…The back cover picture shows an ebsulfur analogue that displays antifungal activity against various clinically relevant fungal Candida and Aspergillus strains,…”
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