Search Results - "Shreeram C. Nallar"

GRIM-19: A master regulator of cytokine induced tumor suppression, metastasis and energy metabolism by Nallar, Shreeram C, Kalvakolanu, Dhan V

“…Graphical abstract GRIM-19, a tumor-suppressive protein interacts with other tumor suppressors, oncoproteins and viral gene products to control tumorigenesis…”
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Regulation of the Death-Associated Protein Kinase 1 Expression and Autophagy via ATF6 Requires Apoptosis Signal-Regulating Kinase 1 by Gade, Padmaja, Manjegowda, Srikanta B., Nallar, Shreeram C., Maachani, Uday B., Cross, Alan S., Kalvakolanu, Dhananjaya V.

“…The death-associated protein kinase 1 (DAPK1) is an important regulator of cell death and autophagy. Recently, we have identified that ATF6, an endoplasmic…”
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Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in mice by Kalakonda, Sudhakar, Nallar, Shreeram C., Jaber, Sausan, Keay, Susan K., Rorke, Ellen, Munivenkatappa, Raghava, Lindner, Daniel J., Fiskum, Gary M., Kalvakolanu, Dhananjaya V.

“…Gene-associated with retinoid-interferon induced mortality-19 (GRIM-19), a STAT3-inhibitory protein, was isolated as a growth-suppressive gene product using a…”
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Inhibition of Mcl-1 Promotes Senescence in Cancer Cells: Implications for Preventing Tumor Growth and Chemotherapy Resistance by Bolesta, Elzbieta, Pfannenstiel, Lukas W., Demelash, Abeba, Lesniewski, Mathew L., Tobin, Megan, Schlanger, Simon E., Nallar, Shreeram C., Papadimitriou, John C., Kalvakolanu, Dhan V., Gastman, Brian R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Critical Role for Transcription Factor C/EBP-β in Regulating the Expression of Death-Associated Protein Kinase 1 by Gade, Padmaja, Roy, Sanjit K., Li, Hui, Nallar, Shreeram C., Kalvakolanu, Dhananjaya V.

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p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA‐dependent interaction by Al‐Khalaf, Huda H., Nallar, Shreeram C., Kalvakolanu, Dhananjaya V., Aboussekhra, Abdelilah

“…p16INK4A and p53 are two important tumor suppressor proteins that play essential roles during cell proliferation and aging through regulating the expression of…”
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GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers by Zhou, Ying, Wei, Ying, Zhu, Jing, Wang, Qingyuan, Bao, Liang, Ma, Yang, Chen, Yu, Feng, Dingqing, Zhang, Aijin, Sun, Jie, Nallar, Shreeram C, Shen, Keng, Kalvakolanu, Dhananjaya V, Xiao, Weihua, Ling, Bin

“…Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction…”
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GRIM-1, a novel growth suppressor, inhibits rRNA maturation by suppressing small nucleolar RNAs by Nallar, Shreeram C, Lin, Limei, Srivastava, Varsha, Gade, Padmaja, Hofmann, Edward R, Ahmed, Hafiz, Reddy, Sekhar P, Kalvakolanu, Dhananjaya V

“…We have recently isolated novel IFN-inducible gene, Gene associated with Retinoid-Interferon-induced Mortality-1 (GRIM-1), using a genetic technique. Moderate…”
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Publisher's Note: Identification and characterization of GRIM-1, a cell-death-associated gene product by Hofmann, Edward R, Nallar, Shreeram C, Lin, Limei, Lindner, Daniel J, Weihua, Xiao, Kalvakolanu, Dhananjaya V

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Bacteria and genetically modified bacteria as cancer therapeutics: Current advances and challenges by Nallar, Shreeram C., Xu, De-Qi, Kalvakolanu, Dhan V.

“…•Facultative anaerobic bacteria grow in hypoxic areas of tumors and suppress growth.•Bacteria can present tumor-associated peptides to the immune…”
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TLR5-Derived, TIR-Interacting Decoy Peptides to Inhibit TLR Signaling by Javmen, Artur, Zou, Jun, Nallar, Shreeram C, Szmacinski, Henryk, Lakowicz, Joseph R, Gewirtz, Andrew T, Toshchakov, Vladimir Y

“…TLR5, which is activated by flagellin, plays an important role in initiating immune response to a broad spectrum of motile bacterial pathogens. TLRs induce…”
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GRIM-19 and p16INK4a Synergistically Regulate Cell Cycle Progression and E2F1-responsive Gene Expression by Sun, Peng, Nallar, Shreeram C., Raha, Abhijit, Kalakonda, Sudhakar, Velalar, Chidambaram N., Reddy, Sekhar P., Kalvakolanu, Dhananjaya V.

“…GRIM-19 (Gene associated with Retinoid-IFN-induced Mortality-19) was originally isolated as a growth suppressor in a genome-wide knockdown screen with…”
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Retraction: Identification and characterization of GRIM-1, a cell-death-associated gene product by Hofmann, Edward R, Nallar, Shreeram C, Lin, Limei, D'Cunha, Jonathan, Lindner, Daniel J, Weihua, Xiao, Kalvakolanu, Dhananjaya V

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Interferons, signal transduction pathways, and the central nervous system by Nallar, Shreeram C, Kalvakolanu, Dhan V

“…The interferon (IFN) family of cytokines participates in the development of innate and acquired immune defenses against various pathogens and pathogenic…”
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The Cyclin-dependent Kinase Inhibitor p16INK4a Physically Interacts with Transcription Factor Sp1 and Cyclin-dependent Kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p Spontaneously and in Response to Ultraviolet Light-induced DNA Damage by Al-Khalaf, Huda H., Mohideen, Peer, Nallar, Shreeram C., Kalvakolanu, Dhananjaya V., Aboussekhra, Abdelilah

“…p16INK4a is a tumor suppressor protein involved in several stress-related cellular responses, including apoptosis. Recent lines of evidence indicate that…”
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Oncosuppressor protein p53 and cyclin-dependent kinase inhibitor p21 regulate interstitial cystitis associated gene expression by Keay, Susan, Nallar, Shreeram C., Gade, Padmaja, Zhang, Chen-Ou, Kalvakolanu, Dhan V.

“…•Interstitial cystitis is associated with changes in the transcription of adhesion molecules.•Tumor suppressor proteins p53 and p21 regulate ZO-1 and…”
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Regulation of snoRNAs in cancer: close encounters with interferon by Nallar, Shreeram C, Kalvakolanu, Dhananjaya V

“…The interferon (IFN) family of cytokines regulates many cellular processes, such as transcription, translation, post-translational modifications, and protein…”
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Tumor-derived Mutations in the Gene Associated with Retinoid Interferon-induced Mortality (GRIM-19) Disrupt Its Anti-signal Transducer and Activator of Transcription 3 (STAT3) Activity and Promote Oncogenesis by Nallar, Shreeram C., Kalakonda, Sudhakar, Lindner, Daniel J., Lorenz, Robert R., Lamarre, Eric, Weihua, Xiao, Kalvakolanu, Dhananjaya V.

“…The signal transducer and activator of transcription 3 (STAT3) protein is critical for multiple cytokine and growth factor-induced biological responses in…”
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p16 INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction by Al-Khalaf, Huda H, Nallar, Shreeram C, Kalvakolanu, Dhananjaya V, Aboussekhra, Abdelilah

“…p16 and p53 are two important tumor suppressor proteins that play essential roles during cell proliferation and aging through regulating the expression of…”
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Cytokine-induced tumor suppressors: A GRIM story by Kalvakolanu, Dhan V., Nallar, Shreeram C., Kalakonda, Sudhakar

“…Cytokines belonging to the IFN family are potent growth suppressors. In a number of clinical and preclinical studies, vitamin A and its derivatives like…”
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