Association of erythrocyte acid phosphatase phenotypes with myopia
Acid phosphatase is a polymorphic nonspecific orthophosphate monoesterase which catalyses the cleaving of phosphoric acid and subsequent breakdown of several monophosphoric esters under acidic pH conditions. Acid phosphatase has a physiologic function as a flavin mononucleotide phosphatase (FMN) and...
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| Published in: | Indian journal of human genetics Vol. 11; no. 1; p. 27 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Mumbai
Medknow Publications on behalf of Indian Society of Human Genetics
01-01-2005
Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Acid phosphatase is a polymorphic nonspecific orthophosphate
monoesterase which catalyses the cleaving of phosphoric acid and
subsequent breakdown of several monophosphoric esters under acidic pH
conditions. Acid phosphatase has a physiologic function as a flavin
mononucleotide phosphatase (FMN) and regulates the intracellular
concentrations of flavin coenzymes that are electron carriers in the
oxidative phosphorylation pathway. Myopia or nearsightedness is caused
by both environmental and genetic factors. Myopic eyes when subjected
to excessive oxidative stress results in retinal detachments .In the
present study there is a significant elevation of AA phenotype in
myopes when compared to controls. The AA phenotype is more susceptible
to oxidative stress and its lower enzyme activity is known to be
associated with increased intrauterine growth that further results in
increased axial length in progressive myopia. The AA phenotype also
confers risk for myopia development in males, early age group and cases
with parental consanguinity. |
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| ISSN: | 0971-6866 1998-362X |
| DOI: | 10.4103/0971-6866.16291 |