Preprogrammed oscillations improve lower limb blood flow and walking distance in patients with peripheral arterial disease

Claudication is one of the sequelae of peripheral arterial disease (PAD). To date, no effective treatment has been found for this condition. To investigate a new device to treat PAD. The device administers pre-programmed protocols of oscillations to the foot. Fifteen patients aged 40-70 years who su...

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Bibliographic Details
Published in:	The Israel Medical Association journal Vol. 16; no. 7; pp. 423 - 426
Main Authors:	Rabin, Igor, Shpolanski, Uri, Leibovitz, Allon, Bass, Arie
Format:	Journal Article
Language:	English
Published:	Israel 01-07-2014
Subjects:	Adult Aged Ankle Brachial Index Blood Gas Monitoring, Transcutaneous Blood Pressure - physiology Equipment Design Female Foot - blood supply Humans Intermittent Claudication - physiopathology Intermittent Claudication - therapy Leg - blood supply Male Middle Aged Oxygen - blood Pain Measurement Peripheral Arterial Disease - physiopathology Peripheral Arterial Disease - therapy Pressure Regional Blood Flow - physiology Skin Temperature - physiology Treatment Outcome Walking - physiology
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Summary:	Claudication is one of the sequelae of peripheral arterial disease (PAD). To date, no effective treatment has been found for this condition. To investigate a new device to treat PAD. The device administers pre-programmed protocols of oscillations to the foot. Fifteen patients aged 40-70 years who suffered from intermittent claudication secondary to PAD were recruited to an open prospective study. Each patient was treated once for 30 minutes. The following parameters were evaluated: pain-free and maximal walking distances, skin blood flux by laser-Doppler, skin temperature, ankle-brachial and toe-brachial indices, transcutaneous oxygen pressure (tcpO2) and transcutaneous carbon dioxide pressure (tcpCO2). Non-parametric signed-rank test was applied for testing differences between baseline assessment and post-treatment assessments for quantitative parameters. Mean pain-free walking distance was 122 +/- 33 m and increased to 277 +/- 67 m, after the treatment session (P = 0.004). Mean maximal walking distance was 213 +/- 37 m and it increased to 603 +/- 77 m (P < 0.001). Foot skin perfusion also improved, as demonstrated by an increase in tcpO2 by 28.6 +/- 4.1 mmHg (P < 0.001), a decrease in tcpCO2 by 2.8 +/- 1.3 (P= 0.032), and up to twofold improvement in blood flux parameters, and an increase in skin temperature by 1.9 +/- 0.5 degrees C (P < 0.001). Ankle-brachial index increased by 0.06 +/- 0.01 (P = 0.003) and toe-brachial index by 0.17 +/- 0.02 (P < 0.001). Preprogrammed oscillations applied to the foot had a positive effect on microcirculation, tissue oxygenation and CO2 clearance; they had a smaller though significant effect on arterial blood pressure indices, and the change in the arterial-brachial index correlated with the change in the pain-free walking distance.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1565-1088