Search Results - "Shpakov, A.O."

Effects of metformin and lutheinizing hormone receptor agonists on steroidogenesis and spermatogenesis in rats with type 2 diabetes with their separate and combined administration by Bakhtyukov, A.A., Derkach, K.V., Stepochkina, A.M., Sorokoumov, V.N., Bayunova, L.V., Lebedev, I.A., Shpakov, A.O.

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Intranasal Co-Administration of Insulin and C-Peptide Restores Metabolic and Hormonal Indices in Rats with Normoinsulinemic, but not with Hyperinsulinemic, Type 2 Diabetes by Stepochkina, A.M., Derkach, K.V., Bondareva, V.M., Bakhtyukov, A.A., Shpakov, A.O.

“…In type 2 diabetes mellitus (T2DM), the functions of the brain insulin system are impaired, which is associated with a decrease in insulin transport across the…”
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Restoration of [beta]-Adrenergic Signaling and Activity of Akt-Kinase and AMP-Activated Protein Kinase with Metformin in the Myocardium of Diabetic Rats by Derkach, K.V, Bondareva, V.M, Kornyushin, O.V, Galagudza, M.M, Shpakov, A.O

“…We studied the effect of metformin (100 and 200 mg/kg/day, 4 weeks) on the adenylyl cyclase-stimulating effects of [beta]-agonists and relaxin in the…”
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Pharmacological approaches for correction of thyroid dysfunctions in diabetes mellitus by Shpakov, A O

“…Thyroid diseases are closely associated with the development of types 1 and 2 diabetes mellitus (DM), and as a consequence, the development of effective…”
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Comparative Study of the Restoring Effect of Metformin, Gonadotropin, and Allosteric Agonist of Luteinizing Hormone Receptor on Spermatogenesis in Male Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus by Derkach, K. V., Bakhtyukov, A. A., Morina, I. Yu, Romanova, I. V., Bayunova, L. V., Shpakov, A. O.

“…We compared the effectiveness of human chorionic gonadotropin (hCG; 5 days, 20 IU/rat/day), allosteric luteinizing hormone receptor agonist TP04 (5 days, 20…”
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Characterization and biological activity of new 4-oxo-1,4-dihydrocinnoline-based inhibitors of the tyrosine phosphatase PTP1B and TCPTP by Derkach, K V, Zakharova, I O, Bakhtyukov, A A, Sorokoumov, V N, Kuznetsova, V S, Shpakov, A O

“…Functional disorders in obesity are largely due to a decrease in tissue sensitivity to insulin and leptin. One of the ways to restore it is inhibition of…”
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The Study of Biological Activity of a New Thieno[2,3-D]-Pyrimidine-Based Neutral Antagonist of Thyrotropin Receptor by Derkach, K. V., Fokina, E. A., Bakhtyukov, A. A., Sorokoumov, V. N., Stepochkina, A. M., Zakharova, I. O., Shpakov, A. O.

“…The development of low-molecular-weight antagonists of thyroid-stimulating hormone (TSH) receptor is a promising trend in the treatment of autoimmune…”
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Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus by Sukhov, I. B., Lebedeva, M. F., Zakharova, I. O., Derkach, K. V., Bayunova, L. V., Zorina, I. I., Avrova, N. F., Shpakov, A. O.

“…We analyzed the effects of intranasal administration of insulin (0.48 U/rat) and gangliosides (6 mg/kg) on spatial memory in rats with the neonatal model of…”
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Intranasal Administration of Proinsulin C-Peptide Enhances the Stimulating Effect of Insulin on Insulin System Activity in the Hypothalamus of Diabetic Rats by Derkach, K. V., Perminova, A. A., Buzanakov, D. M., Shpakov, A. O.

“…In type 1 diabetes mellitus, the levels of insulin and C-peptide decrease at the periphery and in CNS. C-peptide potentiates the regulatory effects of insulin…”
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The Effect of Low-Molecular-Weight Allosteric Agonist of Luteinizing Hormone Receptor on Functional State of the Testes in Aging and Diabetic Rats by Derkach, K. V., Romanova, I. V., Bakhtyukov, A. A., Morina, I. Yu, Dar’in, D. V., Sorokoumov, V. N., Shpakov, A. O.

“…Human chorionic gonadotropin that is widely used for improving spermatogenesis. The effect of chorionic gonadotropin is mediated through luteinizing hormone…”
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Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome by Derkach, K. V., Ivantsov, A. O., Chistyakova, O. V., Sukhov, I. B., Buzanakov, D. M., Kulikova, A. A., Shpakov, A. O.

“…We studied the effect of 10-week treatment with intranasal insulin (0.5 IU/day) on glucose tolerance, glucose utilization, lipid metabolism, functions of…”
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Prospects for use of peptides and their derivatives, structurally corresponding to the G protein-coupled receptors, in medicine by Shpakov, A O, Shpakova, E A

“…The regulation of signaling pathways involved in the control of many physiological functions is carried out via the heterotrimeric G protein-coupled receptors…”
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Regulation of the Melanocortin-Sensitive Adenylate Cyclase System by N-Acylated Peptide 71-82 of Type 4 Melanocortin Receptor by Shpakov, A. O., Derkach, K. V., Shpakova, E. A.

“…The peptides structurally corresponding in to cytoplasmic loops of G protein-coupled receptors (GPCR) are able to control functional activity of homologous…”
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Palmitoylated Peptide 562-572 of Luteinizing Hormone Receptor Increases Testosterone Level in Male Rats by Derkach, K. V., Shpakova, E. A., Shpakov, A. O.

“…We studied the effect of intraperitoneal and intratesticular administration of NKDTKIAKKNle-A 562-572 peptide and its palmotoylated analog NKDTKIAKK-Nle-A…”
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Androgen Deficiency in Male Rats with Prolonged Neonatal Streptozotocin Diabetes by Derkach, K. V., Moyseyuk, I. V., Chistyakova, O. V., Shpakov, A. O.

“…We studied the diurnal dynamics of testosterone concentration in male rats with 240-day neonatal streptozotocin-induced diabetes mellitus, which is similar to…”
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Effect of Peptides Corresponding to Extracellular Domains of Serotonin 1B/1D Receptors and Melanocortin 3 and 4 Receptors on Hormonal Regulation of Adenylate Cyclase in Rat Brain by Shpakova, E. A., Derkach, K. V., Shpakov, A. O.

“…The ligand-recognizing part of G protein-coupled receptors consists of their extracellular loops and N-terminal domain. Identifi cation of these sites is…”
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Development of non-hormonal regulators of adenylyl cyclase signaling system on the basis of peptides, derivatives of the third intracellular loop of somatostatin receptors by Shpakov, A O, Shpakova, E A

“…In the majority of the serpentine type receptors the third intracellular loop (ICL-3) is responsible for interaction with heterotrimeric G-proteins and for…”
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Low-molecular regulators of polypeptide hormones receptors containing LGR repeats by Shpakov, A O, Shpakova, E A

“…During the last years the low-molecular non-peptidic regulators of the polypeptide hormones receptors containing LGR-repeats were identified. In the review the…”
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Glucose and Cyclic Adenosine Monophosphate Stimulate Activities of Adenylate Cyclase and Guanylate Cyclase of Tetrahymena Pyriformis Infusoria by Shpakov, A. O., Derkach, K. V., Uspenskaya, Z. I.

“…The sensitivities of cyclase enzymes adenylate cyclase and guanylate cyclase to glucose and extracellular cAMP were studied in Tetrahymena pyriformis…”
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Initial Stages of the Insulin Signaling System in the Brain of Rats with Experimental Diabetes Mellitus by Chistyakova, O. V., Sukhov, I. B., Loshkareva, M. L., Shipilov, V. N., Bondareva, V. M., Shpakov, A. O.

“…We studied reactivity of insulin signal pathway elements, insulin receptor and insulin receptor substrate protein-2 (IRS2 protein), in rat brain in response to…”
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