Search Results - "Shpakov, A. O"

The Effects of Human Chorionic Gonadotropin and Gonadotropin-Releasing Hormone Receptor Antagonist on Testicular Steroidogenesis in Normal and Obese Rats by Lebedev, I. A., Kuznetsova, V. S., Bakhtyukov, A. A., Shpakov, A. O.

“…We studied the effect of a high-fat, high-carbohydrate diet (HFHCD) on basal testosterone levels in the blood and testosterone, its precursors, and expression…”
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Regulatory Effects of 5-Day Oral and Intraperitoneal Administration of a Thienopyrimidine Derivative on the Thyroid Status in Rats by Derkach, K. V., Sorokoumov, V. N., Morina, I. Yu, Kuznetsova, V. S., Romanova, I. V., Shpakov, A. O.

“…In experiments on rats, we studied the effect of 5-day intraperitoneal (15 mg/kg/day) and oral (40 mg/kg/day) administration of compound TPY3m, a stimulator of…”
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The Study of Biological Activity of a New Thieno[2,3-D]-Pyrimidine-Based Neutral Antagonist of Thyrotropin Receptor by Derkach, K. V., Fokina, E. A., Bakhtyukov, A. A., Sorokoumov, V. N., Stepochkina, A. M., Zakharova, I. O., Shpakov, A. O.

“…The development of low-molecular-weight antagonists of thyroid-stimulating hormone (TSH) receptor is a promising trend in the treatment of autoimmune…”
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New Thieno-[2,3-d]pyrimidine-Based Functional Antagonist for the Receptor of Thyroid Stimulating Hormone by Derkach, K. V., Bakhtyukov, A. A., Sorokoumov, V. N., Shpakov, A. O.

“…Thyroid stimulating hormone (TSH) receptor antagonists are required for the treatment of TSH-dependent tumors and Graves disease. We developed the compound…”
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Allosteric Sites and Allosteric Regulators of G Protein-Coupled Receptors: Gray Cardinals of Signal Transduction by Shpakov, A. O.

“…Membrane G protein-coupled receptors (GPCRs) are key components of most eukaryotic signaling systems, transducing external signals to intracellular effector…”
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Endogenous and Synthetic Regulators of the Peripheral Components of the Hypothalamo-Hypophyseal-Gonadal and -Thyroid Axes by Shpakov, A. O.

“…Activity in the peripheral components of the hypothalamo-hypophyseal-gonadal and -thyroid axes is regulated by hypophyseal hormones – gonadotropins and…”
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Angiotensin-Converting Enzyme Type 2 as a Molecular Mediator for Infection of Cells with SARS-CoV and SARS-CoV-2 Viruses by Shpakov, A. O.

“…Penetration of coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), the cause of the COVID-19 pandemic, into cells requires interaction of…”
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Peptide autoinducers in bacteria by Shpakov, A. O

“…The review classifies and analyzes the literature data on bacterial peptide autoinducers (AIs), responsible for intra- and interspecies communication (quorum…”
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QS-type bacterial signal molecules of nonpeptide origin by Shpakov, A. O

“…This review classifies and analyzes the literature data on bacterial autoinducers (AI), the signal molecules produced and secreted by bacterial cells and…”
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Thyroid-Stimulating Hormone Receptor: the Role in the Development of Thyroid Pathology and Its Correction by Fokina, E. F., Shpakov, A. O.

“…One of the key elements responsible for the thyroid response to thyroid-stimulating hormone (TSH) is the TSH receptor (TSHR), which belongs to the G…”
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Efficacy of Metformin Course Application Combined with Intranasal Insulin in Treating Rats with Cafeteria Diet-Induced Obesity by Derkach, K. V., Zorina, I. I., Shpakov, A. O.

“…The so-called cafeteria diet (CD), rich in saturated fats and light fast-digesting carbohydrates, leads to obesity and is a risk factor for type 2 diabetes…”
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Polycationic peptides as nonhormonal regulators of chemosignal systems by Shpakov, A. O

“…This review summarizes and analyzes both literature data and results of our own studies on molecular mechanisms of action of natural and artificially created…”
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Molecular Mechanisms of the Relationship between Thyroid Dysfunctions and Diabetes Mellitus by Shpakov, A. O.

“…Type 1 and type 2 diabetes mellitus (DM) are known to increase the incidence of thyroid gland (TG) dysfunctions. The review addresses the literature data and…”
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Chemocommunication between bacteria and the higher vertebrate animals by Shpakov, A. O

“…Between bacteria and the higher vertebrate animals there are close chemocommunicational connections that are realized via signal molecules secreted by…”
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Functional Activity of the Insulin Signaling System of the Brain in Health and Type 2 Diabetes Mellitus by Shpakov, A. O.

“…The insulin signal system of the brain plays a key role in regulating fundamental cellular process in neurons, and it controls metabolic processes in the CNS…”
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Changes in Hormone Sensitivity of the Adenylate Cyclase Signaling System in the Testicular Tissue of Rats with Neonatal Streptozotocin-Induced Diabetes by Shpakov, A. O, Derkach, K. V, Bondareva, V. M

“…Activity of the adenylate cyclase signaling system was evaluated in the testicular tissue of rats with neonatal streptozotocin-induced diabetes (120 and 180…”
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Mechanisms of action and therapeutic potential of proinsulin C-peptide by Shpakov, A. O.

“…C-peptide generated by proinsulin proteolysis is not only a chaperone for insulin in β-cells, but also a signaling molecule that regulates many physiological…”
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Neuronal NO Synthase in the Pathogenesis of Metabolic Syndrome by Kuznetsova, L. A., Basova, N. E., Shpakov, A. O.

“…In recent years, metabolic syndrome (MS), which is characterized by obesity, hypertension, dyslipidemia, and insulin resistance, has become an epidemic…”
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Pharmacological approaches for correction of thyroid dysfunctions in diabetes mellitus by Shpakov, A. O.

“…Thyroid diseases are closely associated with the development of types 1 and 2 diabetes mellitus (DM), and the development of effective approaches for their…”
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Effect of Intranasal Insulin on Metabolic Parameters and Inflammation Factors in Diabetic Rats Exposed to Cerebral Ischemia-Reperfusion by Zorina, I. I., Pechalnova, A. S., Chernenko, E. E., Derkach, K. V., Shpakov, A. O.

“…The search for natural biologically active substances having a neuroprotective effect against cerebral ischemia-reperfusion injury is one of the major…”
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