Search Results - "Shozo Nishida"

Dimethyl fumarate suppresses metastasis and growth of melanoma cells by inhibiting the nuclear translocation of NF-κB by Takeda, Tomoya, Tsubaki, Masanobu, Asano, Ryota, Itoh, Tatsuki, Imano, Motohiro, Satou, Takao, Nishida, Shozo

“…•DMF prolongs survival in mice by inhibiting spontaneous metastasis and tumor growth.•DMF prevented the nuclear translocation of NF-κB.•DMF regulates the…”
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Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation by Morii, Yusuke, Tsubaki, Masanobu, Takeda, Tomoya, Otubo, Rie, Seki, Shiori, Yamatomo, Yuta, Imano, Motohiro, Satou, Takao, Shimomura, Kazunori, Nishida, Shozo

“…Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutation in colon cancer contributes to the poor prognosis of the disease and…”
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Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells by Fujiwara, Daichiro, Tsubaki, Masanobu, Takeda, Tomoya, Tomonari, Yoshika, Koumoto, Yu-ichi, Sakaguchi, Katsuhiko, Nishida, Shozo

“…Recently, statins have been demonstrated to improve cancer-related mortality or prognosis in patients of various cancers. However, the details of the…”
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Risk factors for cisplatin-induced nephrotoxicity and potential of magnesium supplementation for renal protection by Kidera, Yasuhiro, Kawakami, Hisato, Sakiyama, Tsutomu, Okamoto, Kunio, Tanaka, Kaoru, Takeda, Masayuki, Kaneda, Hiroyasu, Nishina, Shin-ichi, Tsurutani, Junji, Fujiwara, Kimiko, Nomura, Morihiro, Yamazoe, Yuzuru, Chiba, Yasutaka, Nishida, Shozo, Tamura, Takao, Nakagawa, Kazuhiko

“…Nephrotoxicity remains a problem for patients who receive cisplatin chemotherapy. We retrospectively evaluated potential risk factors for cisplatin-induced…”
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Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells by Tsubaki, Masanobu, Takeda, Tomoya, Noguchi, Masaki, Jinushi, Minami, Seki, Shiori, Morii, Yuusuke, Shimomura, Kazunori, Imano, Motohiro, Satou, Takao, Nishida, Shozo

“…RAS and BRAF-mutated colorectal cancers are associated with resistance to chemotherapy and poor prognosis, highlighting the need for new therapeutic…”
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Dimethyl Fumarate Induces Apoptosis via Inhibition of NF-κB and Enhances the Effect of Paclitaxel and Adriamycin in Human TNBC Cells by Tsurushima, Katsumasa, Tsubaki, Masanobu, Takeda, Tomoya, Matsuda, Takuya, Kimura, Akihiro, Takefuji, Honoka, Okada, Akane, Sakamoto, Chiaki, Ishizaka, Toshihiko, Nishida, Shozo

“…Triple-negative breast cancer (TNBC) has the poorest prognosis of all breast cancer subtypes. Recently, the activation of NF-κB, which is involved in the…”
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Inhibition of HSP90 overcomes melphalan resistance through downregulation of Src in multiple myeloma cells by Tabata, Mitsuki, Tsubaki, Masanobu, Takeda, Tomoya, Tateishi, Keisuke, Maekawa, Saho, Tsurushima, Katsumasa, Imano, Motohiro, Satou, Takao, Ishizaka, Toshihiko, Nishida, Shozo

“…Multiple myeloma (MM) is the second most common hematologic malignancy. In spite of the development of new therapeutic agents, MM remains incurable due to…”
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Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway by Tsubaki, Masanobu, Takeda, Tomoya, Matsumoto, Mikihiro, Kato, Natsuki, Yasuhara, Shota, Koumoto, Yu-ichi, Imano, Motohiro, Satou, Takao, Nishida, Shozo

“…Chemotherapy-induced neuropathy is a highly problematic, dose-limiting effect of potentially curative regimens of cancer chemotherapy. When neuropathic pain is…”
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Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma by Yanae, Masashi, Tsubaki, Masanobu, Satou, Takao, Itoh, Tatsuki, Imano, Motohiro, Yamazoe, Yuzuru, Nishida, Shozo

“…Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme…”
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Inhibition of yes-associated protein suppresses migration, invasion, and metastasis in non-small cell lung cancer in vitro and in vivo by Takeda, Tomoya, Tsubaki, Masanobu, Genno, Shuji, Matsuda, Takuya, Yamamoto, Yuuta, Kimura, Akihiro, Shimizu, Nao, Nishida, Shozo

“…Non-small cell lung cancer (NSCLC) is a highly aggressive cancer with one of the most prevalent malignant tumors. Metastasis in NSCLC is the major cause of…”
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Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy by Tsubaki, Masanobu, Takeda, Tomoya, Matsuda, Takuya, Kishimoto, Kana, Takefuji, Honoka, Taniwaki, Yuzuki, Ueda, Misa, Hoshida, Tadafumi, Tanabe, Kazufumi, Nishida, Shozo

“…KRAS mutations are fraught with the progression of colorectal cancer and resistance to chemotherapy. There are pathways such as extracellular regulated protein…”
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Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3 by Takeda, Tomoya, Tsubaki, Masanobu, Tomonari, Yoshika, Kawashima, Keishi, Itoh, Tatsuki, Imano, Motohiro, Satou, Takao, Nishida, Shozo

“…Bavachin is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. In this study, we examined the effect of bavachin in multiple…”
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Bim downregulation by activation of NF-κB p65, Akt, and ERK1/2 is associated with adriamycin and dexamethasone resistance in multiple myeloma cells by Tsubaki, Masanobu, Takeda, Tomoya, Matsuda, Takuya, Kishimoto, Kana, Tanaka, Remi, Tsurushima, Katsumasa, Ishizaka, Toshihiko, Nishida, Shozo

“…Multiple myeloma (MM) frequently acquires multidrug resistance (MDR), which is due to poor prognosis. Our previous study indicated that high expression of…”
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Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model by Takeda, Tomoya, Tsubaki, Masanobu, Sakamoto, Kotaro, Ichimura, Eri, Enomoto, Aya, Suzuki, Yuri, Itoh, Tatsuki, Imano, Motohiro, Tanabe, Genzoh, Muraoka, Osamu, Matsuda, Hideaki, Satou, Takao, Nishida, Shozo

“…Advanced metastatic melanoma, one of the most aggressive malignancies, is currently without reliable therapy. Therefore, new therapies are urgently needed…”
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Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury by Itoh, Tatsuki, Imano, Motohiro, Nishida, Shozo, Tsubaki, Masahiro, Hashimoto, Shigeo, Ito, Akihiko, Satou, Takao

“…Exercise is reported to inhibit neuronal apoptotic cell death in the hippocampus and improve learning and memory. However, the effect of exercise on inhibition…”
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The HGF/Met/NF-κB Pathway Regulates RANKL Expression in Osteoblasts and Bone Marrow Stromal Cells by Tsubaki, Masanobu, Seki, Shiori, Takeda, Tomoya, Chihara, Akiko, Arai, Yuuko, Morii, Yuusuke, Imano, Motohiro, Satou, Takao, Shimomura, Kazunori, Nishida, Shozo

“…Multiple myeloma (MM)-induced bone disease occurs through hyperactivation of osteoclasts by several factors secreted by MM cells. MM cell-secreted factors…”
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AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor‑sensitive and ‑resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B by Takeda, Tomoya, Tsubaki, Masanobu, Genno, Shuji, Nemoto, Chisato, Onishi, Yasuka, Yamamoto, Yuuta, Imano, Motohiro, Satou, Takao, Nishida, Shozo

“…Imatinib is the gold standard in the conventional treatment of chronic myeloid leukemia (CML). However, some patients become resistant to imatinib therapy. To…”
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Gabapentin and Duloxetine Prevent Oxaliplatin- and Paclitaxel-Induced Peripheral Neuropathy by Inhibiting Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Phosphorylation in Spinal Cords of Mice by Kato, Natsuki, Tateishi, Keisuke, Tsubaki, Masanobu, Takeda, Tomoya, Matsumoto, Mikihiro, Tsurushima, Katsumasa, Ishizaka, Toshihiko, Nishida, Shozo

“…Chemotherapy-induced peripheral neuropathy is a common factor in limiting therapy which can result in therapy cessation or dose reduction. Gabapentin, a…”
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Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway by Tsubaki, Masanobu, Satou, Takao, Itoh, Tatsuki, Imano, Motohiro, Ogaki, Mitsuhiko, Yanae, Masashi, Nishida, Shozo

“…Osteosarcoma is one of the most common primary malignant bone tumors in children and adolescents. Some patients continue to have a poor prognosis, because of…”
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Overexpression of MDR1 and survivin, and decreased Bim expression mediate multidrug-resistance in multiple myeloma cells by Tsubaki, Masanobu, Satou, Takao, Itoh, Tatsuki, Imano, Motohiro, Komai, Makiko, Nishinobo, Minori, Yamashita, Megumi, Yanae, Masashi, Yamazoe, Yuzuru, Nishida, Shozo

“…Abstract Multidrug resistance represents a major obstacle for the chemotherapy of a wide variety of human tumors. To investigate the underlying mechanisms…”
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