Search Results - "Showe, Louise C"

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay by Sakurai, Masayuki, Shiromoto, Yusuke, Ota, Hiromitsu, Song, Chunzi, Kossenkov, Andrew V, Wickramasinghe, Jayamanna, Showe, Louise C, Skordalakes, Emmanuel, Tang, Hsin-Yao, Speicher, David W, Nishikura, Kazuko

“…In stressed cells, the ADAR1p110 isoform is phosphorylated and translocated from the nucleus to the cytoplasm, where it protects transcripts with 3′-UTR dsRNA…”
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The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis by Gumireddy, Kiranmai, Li, Anping, Kossenkov, Andrew V., Sakurai, Masayuki, Yan, Jinchun, Li, Yan, Xu, Hua, Wang, Jian, Zhang, Paul J., Zhang, Lin, Showe, Louise C., Nishikura, Kazuko, Huang, Qihong

“…Metastasis is a critical event affecting breast cancer patient survival. To identify molecules contributing to the metastatic process, we analysed The Cancer…”
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Structural and functional analysis of the human POT1-TPP1 telomeric complex by Rice, Cory, Shastrula, Prashanth Krishna, Kossenkov, Andrew V., Hills, Robert, Baird, Duncan M., Showe, Louise C., Doukov, Tzanko, Janicki, Susan, Skordalakes, Emmanuel

“…POT1 and TPP1 are part of the shelterin complex and are essential for telomere length regulation and maintenance. Naturally occurring mutations of the…”
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Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus by Kim, Kyoung-Dong, Tanizawa, Hideki, De Leo, Alessandra, Vladimirova, Olga, Kossenkov, Andrew, Lu, Fang, Showe, Louise C., Noma, Ken-ichi, Lieberman, Paul M.

“…Epstein-Barr virus (EBV) genomes persist in latently infected cells as extrachromosomal episomes that attach to host chromosomes through the tethering…”
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Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization by Iwasaki, Osamu, Tanizawa, Hideki, Kim, Kyoung-Dong, Kossenkov, Andrew, Nacarelli, Timothy, Tashiro, Sanki, Majumdar, Sonali, Showe, Louise C., Zhang, Rugang, Noma, Ken-ichi

“…Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative…”
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BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer by Yokoyama, Yuhki, Zhu, Hengrui, Lee, Jeong Heon, Kossenkov, Andrew V, Wu, Sherry Y, Wickramasinghe, Jayamanna M, Yin, Xiangfan, Palozola, Katherine C, Gardini, Alessandro, Showe, Louise C, Zaret, Kenneth S, Liu, Qin, Speicher, David, Conejo-Garcia, Jose R, Bradner, James E, Zhang, Zhiguo, Sood, Anil K, Ordog, Tamas, Bitler, Benjamin G, Zhang, Rugang

“…The emergence of tumor cells with certain stem-like characteristics, such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 expression, contributes…”
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Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development by Pal, Sharmistha, Gupta, Ravi, Kim, Hyunsoo, Wickramasinghe, Priyankara, Baubet, Valérie, Showe, Louise C, Dahmane, Nadia, Davuluri, Ramana V

“…Despite our growing knowledge that many mammalian genes generate multiple transcript variants that may encode functionally distinct protein isoforms, the…”
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The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis by Yi, Chunling, Shen, Zhewei, Stemmer-Rachamimov, Anat, Dawany, Noor, Troutman, Scott, Showe, Louise C, Liu, Qin, Shimono, Akihiko, Sudol, Marius, Holmgren, Lars, Stanger, Ben Z, Kissil, Joseph L

“…The Hippo-Yap signaling pathway regulates a number of developmental and adult cellular processes, including cell fate determination, tissue growth, and…”
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Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes by Iwasaki, Osamu, Tanizawa, Hideki, Kim, Kyoung-Dong, Yokoyama, Yuhki, Corcoran, Christopher J., Tanaka, Atsunari, Skordalakes, Emmanuel, Showe, Louise C., Noma, Ken-ichi

“…Genome/chromosome organization is highly ordered and controls various nuclear events, although the molecular mechanisms underlying the functional organization…”
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Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes by Wang, Zhuo, Deng, Zhong, Dahmane, Nadia, Tsai, Kevin, Wang, Pu, Williams, Dewight R., Kossenkov, Andrew V., Showe, Louise C., Zhang, Rugang, Huang, Qihong, Conejo-Garcia, José R., Lieberman, Paul M.

“…Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated regulator of chromosome end protection. Here, we report that TERRA can…”
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KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer by Gumireddy, Kiranmai, Klein-Szanto, Andres J, Gimotty, Phyllis A, Coukos, George, Katsaros, Dionyssios, Huang, Qihong, Showe, Louise C, Li, Anping, Zhang, Lin

“…A screen for suppressors of breast to lung metastasis leads to the identification of KLF17 (Krüppel-like transcription factor 17), which is shown to be…”
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In-Depth, Label-Free Analysis of the Erythrocyte Cytoplasmic Proteome in Diamond Blackfan Anemia Identifies a Unique Inflammatory Signature by Pesciotta, Esther N, Lam, Ho-Sun, Kossenkov, Andrew, Ge, Jingping, Showe, Louise C, Mason, Philip J, Bessler, Monica, Speicher, David W

“…Diamond Blackfan Anemia (DBA) is a rare, congenital erythrocyte aplasia that is usually caused by haploinsufficiency of ribosomal proteins due to diverse…”
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Clinical presentation of COVID-19 – a model derived by a machine learning algorithm by Yousef, Malik, Showe, Louise C., Ben Shlomo, Izhar

“…COVID-19 pandemic has flooded all triage stations, making it difficult to carefully select those most likely infected. Data on total patients tested, infected,…”
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Naïve Bayes for microRNA target predictions—machine learning for microRNA targets by Yousef, Malik, Jung, Segun, Kossenkov, Andrew V., Showe, Louise C., Showe, Michael K.

“…Motivation: Most computational methodologies for miRNA:mRNA target gene prediction use the seed segment of the miRNA and require cross-species sequence…”
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Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus) by Fedorov, Vadim B, Goropashnaya, Anna V, Tøien, Øivind, Stewart, Nathan C, Chang, Celia, Wang, Haifang, Yan, Jun, Showe, Louise C, Showe, Michael K, Barnes, Brian M

“…Hibernation is an adaptive strategy to survive in highly seasonal or unpredictable environments. The molecular and genetic basis of hibernation physiology in…”
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Combining multi-species genomic data for microRNA identification using a Naïve Bayes classifier by Yousef, Malik, Nebozhyn, Michael, Shatkay, Hagit, Kanterakis, Stathis, Showe, Louise C., Showe, Michael K.

“…Motivation: Most computational methodologies for microRNA gene prediction utilize techniques based on sequence conservation and/or structural similarity. In…”
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Comparative functional genomics of adaptation to muscular disuse in hibernating mammals by Fedorov, Vadim B., Goropashnaya, Anna V., Stewart, Nathan C., Tøien, Øivind, Chang, Celia, Wang, Haifang, Yan, Jun, Showe, Louise C., Showe, Michael K., Barnes, Brian M.

“…Hibernation is an energy‐saving adaptation that involves a profound suppression of physical activity that can continue for 6–8 months in highly seasonal…”
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N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance by Fukumoto, Takeshi, Zhu, Hengrui, Nacarelli, Timothy, Karakashev, Sergey, Fatkhutdinov, Nail, Wu, Shuai, Liu, Pingyu, Kossenkov, Andrew V., Showe, Louise C., Jean, Stephanie, Zhang, Lin, Zhang, Rugang

“…Abstract Despite the high initial response rates to PARP inhibitors (PARPi) in BRCA-mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major…”
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Recursive Cluster Elimination based Rank Function (SVM-RCE-R) implemented in KNIME [version 2; peer review: 3 approved] by Yousef, Malik, Bakir-Gungor, Burcu, Jabeer, Amhar, Goy, Gokhan, Qureshi, Rehman, C. Showe, Louise

“…In our earlier study, we proposed a novel feature selection approach, Recursive Cluster Elimination with Support Vector Machines (SVM-RCE) and implemented this…”
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Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles by Tchou, Julia, Kossenkov, Andrew V, Chang, Lisa, Satija, Celine, Herlyn, Meenhard, Showe, Louise C, Puré, Ellen

“…Breast cancer is a heterogeneous disease for which prognosis and treatment strategies are largely governed by the receptor status (estrogen, progesterone and…”
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