Effects of Coadministration of Extract of Carica papaya Linn (family Cariaceae) on Activity of Two Oral Hypoglycemic Agents
Purpose: To investigate the interacting effects of co-administration of Carica papaya leaf extract on the hypoglycemic activity of metformin and glimepiride in an animal model. Method: Experimental factorial design was used to evaluate the individual and interaction influence of three variables ie n...
Saved in:
| Published in: | Tropical journal of pharmaceutical research Vol. 6; no. 1 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
31-07-2007
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Purpose: To investigate the interacting effects of co-administration
of Carica papaya leaf extract on the hypoglycemic activity of metformin
and glimepiride in an animal model. Method: Experimental factorial
design was used to evaluate the individual and interaction influence of
three variables ie nature (N), dose administered (C) and duration of
administration (D), in a 23(=8) employed at two levels -
''high'' and ''low'' -
on blood glucose of diabetic rats on administration of ethanolic leaf
extract of Carica papaya and two hypoglycemic agents, metformin and
glimepiride. Unpaired t-test was used to test for significant
difference due to administration of the combination Results: Extract
of Carica papaya at 5.0 mg/kg produced significant blood glucose
reduction with no significant reduction at the higher dose of 10 mg/kg
(p>0.05). Changing nature from "low" (Carica papaya extract) to
"high" (glimepiride or metformin) did not significantly change
hypoglycemic activity. Generally, the ranking of the interacting
effects was ND>CD>>NC for glimepiride/extract, and
CD>ND>NC for metformin/extract. Administration of higher dose of
the extract led to significant (p<0.01) increase in onset of
activity of glimepiride. The onset of activity of metformin was not
affected, but a significant lowering (p<0.05) of blood glucose was
observed at 24 hr with all combinations of extract and metformin.
Conclusion: Leaf extract of Carica papaya significantly delays the
onset of hypoglycaemic activity of glimepiride, and increases the
hypoglycaemic effect of metformin with the variables interacting
differently for each drug-extract combinations. |
|---|---|
| ISSN: | 1596-5996 1596-9827 |
| DOI: | 10.4314/tjpr.v6i1.14645 |