Search Results - "Shoulkamy, Mahmoud I"

Radiation-induced DNA–protein cross-links: Mechanisms and biological significance by Nakano, Toshiaki, Xu, Xu, Salem, Amir M.H., Shoulkamy, Mahmoud I., Ide, Hiroshi

“…Ionizing radiation produces various DNA lesions such as base damage, DNA single-strand breaks (SSBs), DNA double-strand breaks (DSBs), and DNA–protein…”
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Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells by Nakano, Toshiaki, Shoulkamy, Mahmoud I, Tsuda, Masataka, Sasanuma, Hiroyuki, Hirota, Kouji, Takata, Minoru, Masunaga, Shin-ichiro, Takeda, Shunichi, Ide, Hiroshi, Bessho, Tadayoshi, Tano, Keizo

“…Proteins are covalently trapped on DNA to form DNA-protein cross-links (DPCs) when cells are exposed to DNA-damaging agents. Aldehyde compounds produce common…”
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RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia by Pham, Loc Thi, Peng, Hui, Ueno, Masaya, Kohno, Susumu, Kasada, Atuso, Hosomichi, Kazuyoshi, Sato, Takehiro, Kurayoshi, Kenta, Kobayashi, Masahiko, Tadokoro, Yuko, Kasahara, Atsuko, Shoulkamy, Mahmoud I., Xiao, Bo, Worley, Paul F., Takahashi, Chiaki, Tajima, Atsushi, Hirao, Atsushi

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Translocation and Stability of Replicative DNA Helicases upon Encountering DNA-Protein Cross-links by Nakano, Toshiaki, Miyamoto-Matsubara, Mayumi, Shoulkamy, Mahmoud I., Salem, Amir M.H., Pack, Seung Pil, Ishimi, Yukio, Ide, Hiroshi

“…DNA-protein cross-links (DPCs) are formed when cells are exposed to various DNA-damaging agents. Because DPCs are extremely large, steric hindrance conferred…”
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Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation by Kurayoshi, Kenta, Takase, Yusuke, Ueno, Masaya, Ohta, Kumiko, Fuse, Kyoko, Ikeda, Shuji, Watanabe, Takayoshi, Nishida, Yuki, Horike, Shin-ichi, Hosomichi, Kazuyoshi, Ishikawa, Yuichi, Tadokoro, Yuko, Kobayashi, Masahiko, Kasahara, Atsuko, Jing, Yongwei, Shoulkamy, Mahmoud I., Meguro-Horike, Makiko, Kojima, Kensuke, Kiyoi, Hitoshi, Sugiyama, Hiroshi, Nagase, Hiroki, Tajima, Atsushi, Hirao, Atsushi

“…Differentiation therapy has been proposed as a promising therapeutic strategy for acute myeloid leukemia (AML); thus, the development of more versatile…”
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Detection of DNA-protein crosslinks (DPCs) by novel direct fluorescence labeling methods: distinct stabilities of aldehyde and radiation-induced DPCs by Shoulkamy, Mahmoud I, Nakano, Toshiaki, Ohshima, Makiko, Hirayama, Ryoichi, Uzawa, Akiko, Furusawa, Yoshiya, Ide, Hiroshi

“…Proteins are covalently trapped on DNA to form DNA-protein crosslinks (DPCs) when cells are exposed to DNA-damaging agents. DPCs interfere with many aspects of…”
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DNA–protein cross-links: Formidable challenges to maintaining genome integrity by Ide, Hiroshi, Nakano, Toshiaki, Salem, Amir M.H., Shoulkamy, Mahmoud I.

“…DNA is associated with proteins that are involved in its folding and transaction processes. When cells are exposed to chemical cross-linking agents or free…”
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Case Report: Recent Case Reports of Levant Blunt-Nosed Viper Macrovipera lebetina obtusa Snakebites in Iran by Kazemi, Seyed Mahdi, Al-Sabi, Ahmed, Long, Chengbo, Shoulkamy, Mahmoud I, Abd El-Aziz, Tarek Mohamed

“…Envenomation and death resulting from snakebites represent a significant public health problem worldwide, particularly in tropical and subtropical regions. The…”
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A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite by Ueno, Masaya, Sugiyama, Hiroki, Li, Feng, Nishimura, Tatsuya, Arakawa, Hiroshi, Chen, Xi, Cheng, Xiaoxiao, Takeuchi, Shinji, Takeshita, Yumie, Takamura, Toshinari, Miyagi, Sakae, Toyama, Tadashi, Soga, Tomoyoshi, Masuo, Yusuke, Kato, Yukio, Nakamura, Hiroyuki, Tsujiguchi, Hiromasa, Hara, Akinori, Tajima, Atsushi, Noguchi-Shinohara, Moeko, Ono, Kenjiro, Kurayoshi, Kenta, Kobayashi, Masahiko, Tadokoro, Yuko, Kasahara, Atsuko, Shoulkamy, Mahmoud I., Maeda, Katsuhiro, Ogoshi, Tomoki, Hirao, Atsushi

“…Metabolic abnormalities play a pivotal role in various pathological conditions, necessitating the quantification of specific metabolites for diagnosis. While…”
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Aldehydes with high and low toxicities inactivate cells by damaging distinct cellular targets by Xie, Ming-Zhang, Shoulkamy, Mahmoud I, Salem, Amir M H, Oba, Shunya, Goda, Mizuki, Nakano, Toshiaki, Ide, Hiroshi

“…Aldehydes are genotoxic and cytotoxic molecules and have received considerable attention for their associations with the pathogenesis of various human…”
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Comparative study of the in vivo toxicity and pathophysiology of envenomation by three medically important Egyptian snake venoms by Abd El-Aziz, Tarek M., Shoulkamy, Mahmoud I., Hegazy, Ahmed M., Stockand, James D., Mahmoud, Ahmed, Mashaly, Ashraf M. A.

“…Snakebite envenomation is a serious medical problem in many developing tropical and subtropical countries. Envenomation is registered by the World Health…”
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Repair and biochemical effects of DNA-protein crosslinks by Ide, Hiroshi, Shoulkamy, Mahmoud I, Nakano, Toshiaki, Miyamoto-Matsubara, Mayumi, Salem, Amir M H

“…Genomic DNA is associated with various structural, regulatory, and transaction proteins. The dynamic and reversible association between proteins and DNA…”
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Induction of DNA-protein cross-links by ionizing radiation and their elimination from the genome by Nakano, Toshiaki, Mitsusada, Yusuke, Salem, Amir M H, Shoulkamy, Mahmoud I, Sugimoto, Tatsuya, Hirayama, Ryoichi, Uzawa, Akiko, Furusawa, Yoshiya, Ide, Hiroshi

“…Ionizing radiation produces various types of DNA lesions, such as base damage, single-strand breaks, double-strand breaks (DSBs), and DNA-protein cross-links…”
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