Search Results - "Shou, Wilson"

Current status and future directions of high-throughput ADME screening in drug discovery by Shou, Wilson Z.

“…During the last decade high-throughput in vitro absorption, distribution, metabolism and excretion (HT-ADME) screening has become an essential part of any drug…”
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Acoustic ejection mass spectrometry: Development, applications, and future perspective by Shou, Wilson Z.

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Development of a Predictive Multiple Reaction Monitoring (MRM) Model for High-Throughput ADME Analyses Using Learning-to-Rank (LTR) Techniques by Adalia, Ramon, Patel, Shivani, Paiva, Anthony, Kaufman, Tierni, Zamora, Ismael, Cai, Xianmei, Sanjuan, Gemma, Shou, Wilson Z.

“…Multiple Reaction Monitoring (MRM) is an important MS/MS technique commonly used in drug discovery and development, allowing for the selective and sensitive…”
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Ultrahigh-Throughput and Chromatography-Free Bioanalysis of Polar Analytes with Acoustic Ejection Mass Spectrometry by Wagner, Andrew, Zhang, Jun, Liu, Chang, Covey, Thomas R, Olah, Timothy V, Weller, Harold (Bud) N, Shou, Wilson Z

“…Bioanalysis of polar analytes using liquid chromatography–tandem mass spectrometry (LC-MS/MS) remains a significant challenge because of their poor…”
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Optimization of microflow LC–MS/MS and its utility in quantitative discovery bioanalysis by Zhang, Jun, Shou, Wilson, Ogura, Tairo, Li, Shu, Weller, Harold

“…The sensitivity advantage of microflow LC (μFLC)-MS/MS is potentially impactful for challenging compounds not detectable by conventional flow LC–MS/MS in drug…”
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Characterization of efflux transporters involved in distribution and disposition of apixaban by Zhang, Donglu, He, Kan, Herbst, John J, Kolb, Janet, Shou, Wilson, Wang, Lifei, Balimane, Praveen V, Han, Yong-Hae, Gan, Jinping, Frost, Charles E, Humphreys, W Griffith

“…The studies reported here were conducted to investigate the transport characteristics of apixaban…”
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Recent developments in software tools for high-throughput in vitro ADME support with high-resolution MS by Paiva, Anthony, Shou, Wilson Z

“…The last several years have seen the rapid adoption of the high-resolution MS (HRMS) for bioanalytical support of high throughput in vitro ADME profiling. Many…”
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Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography–electrospray tandem mass spectrometric (HILIC–ESI/MS/MS) bioanalysis of basic compounds by Shou, Wilson Z., Naidong, Weng

“…Trifluoroacetic acid (TFA) is a commonly used additive in HPLC and LC–MS analysis of basic compounds. It is also routinely added to aqueous–organic mobile…”
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Recent development in software and automation tools for high-throughput discovery bioanalysis by Shou, Wilson Z, Zhang, Jun

“…Bioanalysis with LC-MS/MS has been established as the method of choice for quantitative determination of drug candidates in biological matrices in drug…”
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Recent development in high-throughput bioanalytical support for in vitro ADMET profiling by Shou, Wilson Z, Zhang, Jun

“…High-throughput in vitro ADMET (absorption, distribution, metabolism, excretion and toxicity) profiling has become an important common practice in the…”
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Sample reduction strategies in discovery bioanalysis by Cai, Xianmei, Zhang, Jun, Shou, Wilson Z

“…It is a constant challenge to provide timely bioanalytical support for the evaluation of drug-like properties and PK/PD profiles for the ever-increasing…”
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Development, optimization and implementation of a centralized metabolic soft spot assay by Paiva, Anthony A, Klakouski, Cheryl, Li, Shu, Johnson, Benjamin M, Shu, Yue-Zhong, Josephs, Jonathan, Zvyaga, Tatyana, Zamora, Ismael, Shou, Wilson Z

“…High clearance is a commonly encountered issue in drug discovery. Here we present a centralized metabolic soft spot identification assay with adequate capacity…”
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An integrated bioanalytical platform for supporting high-throughput serum protein binding screening by Zhang, Jun, Shou, Wilson Z., Vath, Marianne, Kieltyka, Kasia, Maloney, Jennifer, Elvebak, Larry, Stewart, Jeremy, Herbst, John, Weller, Harold N.

“…Quantification of small molecules using liquid chromatography/tandem mass spectrometry (LC/MS/MS) on a triple quadrupole mass spectrometer has become a common…”
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Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen by Wagner, Andrew D., Kolb, Janet M., Özbal, Can C., Herbst, John J., Olah, Timothy V., Weller, Harold N., Zvyaga, Tatyana A., Shou, Wilson Z.

“…The evaluation of interactions between drug candidates and transporters such as P‐glycoprotein (P‐gp) has gained considerable interest in drug discovery and…”
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'N-in-one' strategy for metabolite identification using a liquid chromatography/hybrid triple quadrupole linear ion trap instrument using multiple dependent product ion scans triggered with full mass scan by Li, Austin C., Gohdes, Mark A., Shou, Wilson Z.

“…This paper describes a new strategy that utilizes the fast trap mode scan of the hybrid triple quadrupole linear ion trap (QqQLIT) for the identification of…”
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Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging by Shou, Wilson Z, Gerritz, Samuel W, Harden, David, Lawrence, R Michael, Chase, Peter, Chin, Jefferson, Surti, Neha, Lippy, Jonathan S, Weller, Harold N, Nielsen, Julia, Weerakoon, Darshani

“…Hits from high-throughput screening (HTS) assays are typically evaluated using cheminformatics and/or empirical approaches before a decision for follow-up…”
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A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen by Kieltyka, Kasia, Zhang, Jun, Li, Shu, Vath, Marianne, Baglieri, Chris, Ferraro, Cheryl, Zvyaga, Tatyana A., Drexler, Dieter M., Weller, Harold N., Shou, Wilson Z.

“…Liquid chromatography/tandem mass spectrometry (LC/MS/MS) is the bioanalytical method of choice to support plate‐based, in vitro early ADME (Absorption,…”
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A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer by Shou, Wilson Z., Magis, Lisa, Li, Austin C., Naidong, Weng, Bryant, Matthew S.

“…In vitro metabolic stability experiments using microsomes or other liver preparations are important components in the discovery and lead‐optimization stages of…”
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Complete profiling and characterization of in vitro nefazodone metabolites using two different tandem mass spectrometric platforms by Li, Austin C., Shou, Wilson Z., Mai, Ting T., Jiang, Xiang-yu

“…This paper describes the complete profiling and characterization of in vitro metabolites of the antidepressant agent nefazodone (NEF) generated by human liver…”
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Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays by Zhang, Jun, Maloney, Jennifer, Drexler, Dieter M, Cai, Xianmei, Stewart, Jeremy, Mayer, Chris, Herbst, John, Weller, Harold, Shou, Wilson Z

“…High-resolution MS (HRMS) has recently received a considerable interest in quantitative bioanalysis using full-scan acquisition mode. The benefits include…”
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