Search Results - "Shook, Brett A"

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair by Shook, Brett A., Wasko, Renee R., Mano, Omer, Rutenberg-Schoenberg, Michael, Rudolph, Michael C., Zirak, Bahar, Rivera-Gonzalez, Guillermo C., López-Giráldez, Francesc, Zarini, Simona, Rezza, Amélie, Clark, Damon A., Rendl, Michael, Rosenblum, Michael D., Gerstein, Mark B., Horsley, Valerie

“…Mature adipocytes store fatty acids and are a common component of tissue stroma. Adipocyte function in regulating bone marrow, skin, muscle, and mammary gland…”
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Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair by Shook, Brett A, Wasko, Renee R, Rivera-Gonzalez, Guillermo C, Salazar-Gatzimas, Emilio, López-Giráldez, Francesc, Dash, Biraja C, Muñoz-Rojas, Andrés R, Aultman, Krystal D, Zwick, Rachel K, Lei, Vivian, Arbiser, Jack L, Miller-Jensen, Kathryn, Clark, Damon A, Hsia, Henry C, Horsley, Valerie

“…During tissue repair, myofibroblasts produce extracellular matrix (ECM) molecules for tissue resilience and strength. Altered ECM deposition can lead to tissue…”
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Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation by Zwick, Rachel K., Rudolph, Michael C., Shook, Brett A., Holtrup, Brandon, Roth, Eve, Lei, Vivian, Van Keymeulen, Alexandra, Seewaldt, Victoria, Kwei, Stephanie, Wysolmerski, John, Rodeheffer, Matthew S., Horsley, Valerie

“…Adipocytes undergo pronounced changes in size and behavior to support diverse tissue functions, but the mechanisms that control these changes are not well…”
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Dermal Drivers of Injury-Induced Inflammation: Contribution of Adipocytes and Fibroblasts by Cooper, Paula O, Haas, MaryEllen R, Noonepalle, Satish Kumar R, Shook, Brett A

“…Irregular inflammatory responses are a major contributor to tissue dysfunction and inefficient repair. Skin has proven to be a powerful model to study…”
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Spatiotemporal changes to the subventricular zone stem cell pool through aging by Shook, Brett A, Manz, David H, Peters, John J, Kang, Sangwook, Conover, Joanne C

“…Through adulthood, the rodent subventricular zone (SVZ) stem cell niche generates new olfactory bulb interneurons. We had previously reported that the number…”
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G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds by Cooper, Paula O., Kleb, Sarah S., Noonepalle, Satish K., Amuso, Veronica M., Varshney, Rohan, Rudolph, Michael C., Dhaliwal, Tanvir K., Nguyen, Darlene V., Mazumder, Miguel F., Babirye, Najuma S., Gupta, Ruchi, Nguyen, Bao-Ngoc, Shook, Brett A.

“…Lipids have emerged as potent regulators of immune cell function. In the skin, adipocyte lipolysis increases the local pool of free fatty acids and is…”
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Characterization of Cre recombinase models for the study of adipose tissue by Jeffery, Elise, Berry, Ryan, Church, Christopher D, Yu, Songtao, Shook, Brett A, Horsley, Valerie, Rosen, Evan D, Rodeheffer, Matthew S

“…The study of adipose tissue in vivo has been significantly advanced through the use of genetic mouse models. While the aP2-Cre BI and aP2-Cre Salk lines have…”
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Cell therapy using ex vivo reprogrammed macrophages enhances antitumor immune responses in melanoma by Noonepalle, Satish Kumar Reddy, Gracia-Hernandez, Maria, Aghdam, Nima, Berrigan, Michael, Coulibaly, Hawa, Li, Xintang, Zevallos-Delgado, Christian, Pletcher, Andrew, Weselman, Bryan, Palmer, Erica, Knox, Tessa, Sotomayor, Eduardo, Chiappinelli, Katherine B, Wardrop, Duncan, Horvath, Anelia, Shook, Brett A, Lee, Norman, Dritschilo, Anatoly, Fernandes, Rohan, Musunuri, Karthik, Shibata, Maho, Villagra, Alejandro

“…Macrophage-based cell therapies have shown modest success in clinical trials, which can be attributed to their phenotypic plasticity, where transplanted…”
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Recovery of Altered Diabetic Myofibroblast Heterogeneity and Gene Expression Are Associated with CD301b+ Macrophages by Haas, MaryEllen R, Nguyen, Darlene V, Shook, Brett A

“…Diabetic wound healing is associated with impaired function and reduced numbers of myofibroblasts, a heterogeneous cell population with varying capacities to…”
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Subventricular Zone-Mediated Ependyma Repair in the Adult Mammalian Brain by Luo, Jie, Shook, Brett A, Daniels, Stephen B, Conover, Joanne C

“…The subventricular zone (SVZ) of the adult mouse brain is a narrow stem cell niche that lies along the length of the lateral wall of the lateral ventricles…”
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PDGFA regulation of dermal adipocyte stem cells by Rivera-Gonzalez, Guillermo C, Shook, Brett A, Horsley, Valerie

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Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis by Rivera-Gonzalez, Guillermo C., Shook, Brett A., Andrae, Johanna, Holtrup, Brandon, Bollag, Katherine, Betsholtz, Christer, Rodeheffer, Matthew S., Horsley, Valerie

“…Tissue growth and maintenance requires stem cell populations that self-renew, proliferate, and differentiate. Maintenance of white adipose tissue (WAT)…”
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Ventriculomegaly associated with ependymal gliosis and declines in barrier integrity in the aging human and mouse brain by Shook, Brett A., Lennington, Jessica B., Acabchuk, Rebecca L., Halling, Meredith, Sun, Ye, Peters, John, Wu, Qian, Mahajan, Amit, Fellows, Douglas W., Conover, Joanne C.

“…Summary Age‐associated ventriculomegaly is typically attributed to neurodegeneration; however, additional factors might initiate or contribute to progressive…”
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Aging of the subventricular zone neural stem cell niche by Conover, Joanne C, Shook, Brett A

“…The persistence of an active subventricular zone neural stem cell niche in the adult mammalian forebrain supports its continued role in the production of new…”
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3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse by Acabchuk, Rebecca L, Sun, Ye, Wolferz, Jr, Richard, Eastman, Matthew B, Lennington, Jessica B, Shook, Brett A, Wu, Qian, Conover, Joanne C

“…The ventricular system carries and circulates cerebral spinal fluid (CSF) and facilitates clearance of solutes and toxins from the brain. The functional units…”
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Abstract 5247: Reprogramming tumor microenvironment with intratumor macrophage adoptive cell therapy in melanoma by Noonepalle, Satish Kumar Reddy, Gajendran, Nithya, Suresh, Manasa, Li, Xintang, Hernandez, Maria D., Delgado, Christian Zevallos, Aghdam, Nima, Berrigen, Michael, Knox, Tessa, Tan, Karen, Durr, Marie, Sotomayor, Eduardo, Chiappinelli, Katherine B., Wardrop, Duncan, Horvath, Anelia, Shook, Brett A., Lee, Norman H., Dritschilo, Anatoly, Fernandes, Rohan, Musunuri, Karthik, Shibata, Maho, Villagra, Alejandro

“…Abstract The interplay between tumor cells and immune cells within the tumor microenvironment (TME) dictates protumor or antitumor immune responses…”
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Abstract 900: Reprogramming macrophages with HDAC6 inhibitors for anti-cancer macrophage-based cell therapy by Noonepalle, Satish Kumar Reddy, Hernandez, Maria Gracia, Delgado, Christian Zevallos, Aghdam, Nima, Gajendran, Nithya, Knox, Tessa, Tan, Karen, Sotomayor, Eduardo, Chiappinelli, Katherine B., Wardrop, Duncan, Horvath, Anelia, Shook, Brett A., Lee, Norman, Dritschilo, Anatoly, Fernandes, Rohan, Shibata, Maho, Musunuri, Karthik, Villagra, Alejandro

“…Abstract Tumor-associated macrophages (TAMs) play a critical role in shaping the tumor microenvironment (TME). Responding to numerous cues from various cell…”
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AGING OF THE SUBVENTRICULAR ZONE NEURAL STEM CELL NICHE by Conover, Joanne C, Shook, Brett A

“…The persistence of an active subventricular zone neural stem cell niche in the adult mammalian forebrain supports its continued role in the production of new…”
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3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse by Acabchuk, Rebecca L., Sun, Ye, Wolferz, Jr, Richard, Eastman, Matthew B., Lennington, Jessica B., Shook, Brett A., Wu, Qian, Conover, Joanne C.

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