Search Results - "Shon, A."

Two Decades of Studying Functional Amyloids in Microorganisms by Levkovich, Shon A., Gazit, Ehud, Laor Bar-Yosef, Dana

“…In the past two decades, amyloids, typically associated with human diseases, have been described to play various functional roles in nearly all life forms. The…”
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The Metabolostasis Network and the Cellular Depository of Aggregation-Prone Metabolites by Levkovich, Shon A, Gazit, Ehud, Laor Bar-Yosef, Dana

“…The vital role of metabolites across all branches of life and their involvement in various disorders have been investigated for decades. Many metabolites are…”
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Mitochondrial complex I ROS production and redox signaling in hypoxia by Okoye, Chidozie N., Koren, Shon A., Wojtovich, Andrew P.

“…Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is the major process of aerobic respiration. Enzyme complexes of the…”
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Tau-mediated dysregulation of RNA: Evidence for a common molecular mechanism of toxicity in frontotemporal dementia and other tauopathies by Koren, Shon A., Galvis-Escobar, Sara, Abisambra, Jose F.

“…Frontotemporal dementias (FTDs) encompass several disorders commonly characterized by progressive frontotemporal lobar degeneration and dementia…”
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Site-specific mitochondrial dysfunction in neurodegeneration by Vodičková, Anežka, Koren, Shon A., Wojtovich, Andrew P.

“…Mitochondria are essential for neuronal survival and mitochondrial dysfunction is a hallmark of neurodegeneration. The loss in mitochondrial energy production,…”
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Microbial Prions: Dawn of a New Era by Levkovich, Shon A., Rencus-Lazar, Sigal, Gazit, Ehud, Laor Bar-Yosef, Dana

“…Protein misfolding and aggregation are associated with human diseases and aging. However, microorganisms widely exploit the self-propagating properties of…”
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BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance by Lin, Heng, Tang, Maoping, Ji, Changyi, Girardi, Peter, Cvetojevic, Gregor, Chen, Daniel, Koren, Shon A., Johnson, Gail V.W.

“…Declining proteostasis with aging contributes to increased susceptibility to neurodegenerative diseases, including Alzheimer’s disease (AD). Emerging studies…”
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The role of BAG3 in health and disease: A “Magic BAG of Tricks” by Lin, Heng, Koren, Shon A., Cvetojevic, Gregor, Girardi, Peter, Johnson, Gail V. W.

“…The multi‐domain structure of Bcl‐2‐associated athanogene 3 (BAG3) facilitates its interaction with many different proteins that participate in regulating a…”
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The von Hippel-Lindau protein forms fibrillar amyloid assemblies that are mitigated by the anti-amyloid molecule Purpurin by Kumar, Vijay, Kaushik, Vibha, Kumar, Sourav, Levkovich, Shon A, Gupta, Priya, Laor Bar-Yosef, Dana, Gazit, Ehud, Segal, Daniel

“…The von Hippel-Lindau protein (pVHL) is a tumor suppressor involved in oxygen regulation via dynamic nucleocytoplasmic shuttling. It plays a crucial role in…”
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Mind your marker: the effect of common auxotrophic markers on complex traits in yeast by Kaplan, Keila, Levkovich, Shon A, DeRowe, Yasmin, Gazit, Ehud, Laor Bar-Yosef, Dana

“…Yeast cells are extensively used as a key model organism owing to their highly conserved genome, metabolic pathways, and cell biology processes. To assist in…”
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A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans by Onukwufor, John O., Farooqi, M. Arsalan, Vodičková, Anežka, Koren, Shon A., Baldzizhar, Aksana, Berry, Brandon J., Beutner, Gisela, Porter, George A., Belousov, Vsevolod, Grossfield, Alan, Wojtovich, Andrew P.

“…C. elegans react to metabolic distress caused by mismatches in oxygen and energy status via distinct behavioral responses. At the molecular level, these…”
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Tau drives translational selectivity by interacting with ribosomal proteins by Koren, Shon A., Hamm, Matthew J., Meier, Shelby E., Weiss, Blaine E., Nation, Grant K., Chishti, Emad A., Arango, Juan Pablo, Chen, Jing, Zhu, Haining, Blalock, Eric M., Abisambra, Jose F.

“…There is a fundamental gap in understanding the consequences of tau–ribosome interactions. Tau oligomers and filaments hinder protein synthesis in vitro, and…”
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All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ by Koren, Shon A., Ahmed Selim, Nada, De la Rosa, Lizbeth, Horn, Jacob, Farooqi, M. Arsalan, Wei, Alicia Y., Müller-Eigner, Annika, Emerson, Jacen, Johnson, Gail V. W., Wojtovich, Andrew P.

“…Hydrogen peroxide (H 2 O 2 ) functions as a second messenger to signal metabolic distress through highly compartmentalized production in mitochondria. The…”
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A Recombinant Vesicular Stomatitis Virus Ebola Vaccine by Regules, Jason A, Beigel, John H, Paolino, Kristopher M, Voell, Jocelyn, Castellano, Amy R, Hu, Zonghui, Muñoz, Paula, Moon, James E, Ruck, Richard C, Bennett, Jason W, Twomey, Patrick S, Gutiérrez, Ramiro L, Remich, Shon A, Hack, Holly R, Wisniewski, Meagan L, Josleyn, Matthew D, Kwilas, Steven A, Van Deusen, Nicole, Mbaya, Olivier Tshiani, Zhou, Yan, Stanley, Daphne A, Jing, Wang, Smith, Kirsten S, Shi, Meng, Ledgerwood, Julie E, Graham, Barney S, Sullivan, Nancy J, Jagodzinski, Linda L, Peel, Sheila A, Alimonti, Judie B, Hooper, Jay W, Silvera, Peter M, Martin, Brian K, Monath, Thomas P, Ramsey, W. Jay, Link, Charles J, Lane, H. Clifford, Michael, Nelson L, Davey, Richard T, Thomas, Stephen J

“…This final report updates preliminary data on an attenuated, replication-competent, recombinant vesicular stomatitis virus–based vaccine candidate designed to…”
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Performance of ultra-thin SOI-based resonators for sensing applications by Fard, Sahba Talebi, Donzella, Valentina, Schmidt, Shon A, Flueckiger, Jonas, Grist, Samantha M, Talebi Fard, Pouria, Wu, Yichen, Bojko, Rick J, Kwok, Ezra, Jaeger, Nicolas A F, Ratner, Daniel M, Chrostowski, Lukas

“…This work presents simulation and experimental results of ultra-thin optical ring resonators, having larger Evanescent Field (EF) penetration depths, and…”
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A Phase 2 Study Evaluating the Safety, Tolerability, and Immunogenicity of Two 3-Dose Regimens of a Clostridium difficile Vaccine in Healthy US Adults Aged 65 to 85 Years by Kitchin, Nicholas, Remich, Shon A, Peterson, James, Peng, Yahong, Gruber, William C, Jansen, Kathrin U, Pride, Michael W, Anderson, Annaliesa S, Knirsch, Charles, Webber, Chris

“…Abstract Background Clostridium difficile causes toxin-mediated nosocomial diarrhea and community-acquired infections; no preventive vaccine is licensed. In…”
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Author Correction: All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ by Koren, Shon A., Ahmed Selim, Nada, De la Rosa, Lizbeth, Horn, Jacob, Farooqi, M. Arsalan, Wei, Alicia Y., Müller-Eigner, Annika, Emerson, Jacen, Johnson, Gail V. W., Wojtovich, Andrew P.

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Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration by Cloyd, Ryan A, Koren, Shon A, Abisambra, Jose F

“…Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery…”
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Chemical Chaperones Modulate the Formation of Metabolite Assemblies by Adsi, Hanaa, Levkovich, Shon A, Haimov, Elvira, Kreiser, Topaz, Meli, Massimiliano, Engel, Hamutal, Simhaev, Luba, Karidi-Heller, Shai, Colombo, Giorgio, Gazit, Ehud, Laor Bar-Yosef, Dana

“…The formation of amyloid-like structures by metabolites is associated with several inborn errors of metabolism (IEMs). These structures display most of the…”
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Selective disruption of Drp1-independent mitophagy and mitolysosome trafficking by an Alzheimer’s disease relevant tau modification in a novel Caenorhabditis elegans model by Guha, Sanjib, Cheng, Anson, Carroll, Trae, King, Dennisha, Koren, Shon A, Swords, Sierra, Nehrke, Keith, Johnson, Gail V W

“…Abstract Accumulation of inappropriately phosphorylated tau into neurofibrillary tangles is a defining feature of Alzheimer’s disease, with Tau pT231 being an…”
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