Search Results - "Sholl, Lynette M"

Biomarkers of response to checkpoint inhibitors beyond PD-L1 in lung cancer by Sholl, Lynette M.

“…Immunotherapy, including use of checkpoint inhibitors against PD-1, PD-L1, and CTLA-4, forms the backbone of oncologic management for the majority of non-small…”
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The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy by Scherz-Shouval, Ruth, Santagata, Sandro, Mendillo, Marc L., Sholl, Lynette M., Ben-Aharon, Irit, Beck, Andrew H., Dias-Santagata, Dora, Koeva, Martina, Stemmer, Salomon M., Whitesell, Luke, Lindquist, Susan

“…Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Surprisingly little is known about the factors that drive…”
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Biomarkers in lung adenocarcinoma: a decade of progress by Sholl, Lynette M

“…The analysis of molecular biomarkers in lung adenocarcinoma (ACA) is now a central component of pathologic diagnosis and oncologic care. The identification of…”
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PD-1 Inhibitor-Related Pneumonitis in Advanced Cancer Patients: Radiographic Patterns and Clinical Course by Nishino, Mizuki, Ramaiya, Nikhil H, Awad, Mark M, Sholl, Lynette M, Maattala, Jennifer A, Taibi, Myriam, Hatabu, Hiroto, Ott, Patrick A, Armand, Philippe F, Hodi, F Stephen

“…Investigate the clinical characteristics, radiographic patterns, and treatment course of PD-1 inhibitor-related pneumonitis in advanced cancer patients. Among…”
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A Grading System for Invasive Pulmonary Adenocarcinoma: A Proposal From the International Association for the Study of Lung Cancer Pathology Committee by Moreira, Andre L, Ocampo, Paolo S S, Xia, Yuhe, Zhong, Hua, Russell, Prudence A, Minami, Yuko, Cooper, Wendy A, Yoshida, Akihiko, Bubendorf, Lukas, Papotti, Mauro, Pelosi, Giuseppe, Lopez-Rios, Fernando, Kunitoki, Keiko, Ferrari-Light, Dana, Sholl, Lynette M, Beasley, Mary Beth, Borczuk, Alain, Botling, Johan, Brambilla, Elisabeth, Chen, Gang, Chou, Teh-Ying, Chung, Jin-Haeng, Dacic, Sanja, Jain, Deepali, Hirsch, Fred R, Hwang, David, Lantuejoul, Sylvie, Lin, Dongmei, Longshore, John W, Motoi, Noriko, Noguchi, Masayuki, Poleri, Claudia, Rekhtman, Natasha, Tsao, Ming-Sound, Thunnissen, Erik, Travis, William D, Yatabe, Yasushi, Roden, Anja C, Daigneault, Jillian B, Wistuba, Ignacio I, Kerr, Keith M, Pass, Harvey, Nicholson, Andrew G, Mino-Kenudson, Mari

“…A grading system for pulmonary adenocarcinoma has not been established. The International Association for the Study of Lung Cancer pathology panel evaluated a…”
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Strategies for the successful implementation of plasma-based NSCLC genotyping in clinical practice by Aggarwal, Charu, Rolfo, Christian D., Oxnard, Geoffrey R., Gray, Jhanelle E., Sholl, Lynette M., Gandara, David R.

“…Upfront tumour genotyping is now considered an essential step in guiding treatment decision-making in the management of patients with advanced-stage…”
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Implications of the tumor immune microenvironment for staging and therapeutics by Taube, Janis M, Galon, Jérôme, Sholl, Lynette M, Rodig, Scott J, Cottrell, Tricia R, Giraldo, Nicolas A, Baras, Alexander S, Patel, Sanjay S, Anders, Robert A, Rimm, David L, Cimino-Mathews, Ashley

“…Characterizing the tumor immune microenvironment enables the identification of new prognostic and predictive biomarkers, the development of novel therapeutic…”
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Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status by Ricciuti, Biagio, Arbour, Kathryn C, Lin, Jessica J, Vajdi, Amir, Vokes, Natalie, Hong, Lingzhi, Zhang, Jianjun, Tolstorukov, Michael Y, Li, Yvonne Y, Spurr, Liam F, Cherniack, Andrew D, Recondo, Gonzalo, Lamberti, Giuseppe, Wang, Xinan, Venkatraman, Deepti, Alessi, Joao V, Vaz, Victor R, Rizvi, Hira, Egger, Jacklynn, Plodkowski, Andrew J, Khosrowjerdi, Sara, Digumarthy, Subba, Park, Hyesun, Vaz, Nuno, Nishino, Mizuki, Sholl, Lynette M, Barbie, David, Altan, Mehmet, Heymach, John V, Skoulidis, Ferdinandos, Gainor, Justin F, Hellmann, Matthew D, Awad, Mark M

“…STK11 and KEAP1 mutations (STK11 mutant [STK11 ] and KEAP1 ) are among the most often mutated genes in lung adenocarcinoma (LUAD). Although STK11 has been…”
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Validation of OncoPanel: A Targeted Next-Generation Sequencing Assay for the Detection of Somatic Variants in Cancer by Garcia, Elizabeth P, Minkovsky, Alissa, Jia, Yonghui, Ducar, Matthew D, Shivdasani, Priyanka, Gong, Xin, Ligon, Azra H, Sholl, Lynette M, Kuo, Frank C, MacConaill, Laura E, Lindeman, Neal I, Dong, Fei

“…- The analysis of somatic mutations across multiple genes in cancer specimens may be used to aid clinical decision making. The analytical validation of…”
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Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection by Desai, Niyati, Neyaz, Azfar, Szabolcs, Annamaria, Shih, Angela R., Chen, Jonathan H., Thapar, Vishal, Nieman, Linda T., Solovyov, Alexander, Mehta, Arnav, Lieb, David J., Kulkarni, Anupriya S., Jaicks, Christopher, Xu, Katherine H., Raabe, Michael J., Pinto, Christopher J., Juric, Dejan, Chebib, Ivan, Colvin, Robert B., Kim, Arthur Y., Monroe, Robert, Warren, Sarah E., Danaher, Patrick, Reeves, Jason W., Gong, Jingjing, Rueckert, Erroll H., Greenbaum, Benjamin D., Hacohen, Nir, Lagana, Stephen M., Rivera, Miguel N., Sholl, Lynette M., Stone, James R., Ting, David T., Deshpande, Vikram

“…The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients…”
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The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors? by Marx, Alexander, Chan, John K C, Chalabreysse, Lara, Dacic, Sanja, Detterbeck, Frank, French, Christopher A, Hornick, Jason L, Inagaki, Hiroshi, Jain, Deepali, Lazar, Alexander J, Marino, Mirella, Marom, Edith M, Moreira, Andre L, Nicholson, Andrew G, Noguchi, Masayuki, Nonaka, Daisuke, Papotti, Mauro G, Porubsky, Stefan, Sholl, Lynette M, Tateyama, Hisashi, Thomas de Montpréville, Vincent, Travis, William D, Rajan, Arun, Roden, Anja C, Ströbel, Philipp

“…This overview of the fifth edition of the WHO classification of thymic epithelial tumors (including thymomas, thymic carcinomas, and thymic neuroendocrine…”
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Clinical and molecular validation of BAP1, MTAP, P53, and Merlin immunohistochemistry in diagnosis of pleural mesothelioma by Chapel, David B., Hornick, Jason L., Barlow, Julianne, Bueno, Raphael, Sholl, Lynette M.

“…BAP1 and MTAP immunostains play an important role in diagnosis of mesothelioma, but additional markers are needed to increase sensitivity. We analyzed 84…”
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Comparison of RNA In Situ Hybridization and Immunohistochemistry Techniques for the Detection and Localization of SARS-CoV-2 in Human Tissues by Massoth, Lucas R., Desai, Niyati, Szabolcs, Annamaria, Harris, Cynthia K., Neyaz, Azfar, Crotty, Rory, Chebib, Ivan, Rivera, Miguel N., Sholl, Lynette M., Stone, James R., Ting, David T., Deshpande, Vikram

“…Coronavirus disease-19 (COVID-19) is caused by a newly discovered coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although…”
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Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer by Ricciuti, Biagio, Recondo, Gonzalo, Spurr, Liam F, Li, Yvonne Y, Lamberti, Giuseppe, Venkatraman, Deepti, Umeton, Renato, Cherniack, Andrew D, Nishino, Mizuki, Sholl, Lynette M, Shapiro, Geoffrey I, Awad, Mark M, Cheng, Michael L

“…DNA damage response and repair (DDR) gene alterations are associated with increased tumor-infiltrating lymphocytes, higher genomic instability, and higher…”
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Distinctive Patterns of CTNNB1 (β-Catenin) Alterations in Salivary Gland Basal Cell Adenoma and Basal Cell Adenocarcinoma by Jo, Vickie Y, Sholl, Lynette M, Krane, Jeffrey F

“…Salivary gland basaloid neoplasms are diagnostically challenging. Limited publications report that some basal cell adenomas harbor CTNNB1 mutations, and…”
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Imaging of Precision Therapy for Lung Cancer: Current State of the Art by Park, Hyesun, Sholl, Lynette M, Hatabu, Hiroto, Awad, Mark M, Nishino, Mizuki

“…Advances in characterization of molecular and genomic abnormalities specific to lung cancer have made precision therapy the current standard of care for lung…”
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Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care by Nishino, Mizuki, Hatabu, Hiroto, Sholl, Lynette M, Ramaiya, Nikhil H

“…Recent advances in understanding the molecular mechanisms of cancer have opened a new era of precision medicine for cancer treatment. Precision cancer…”
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Predictive Biomarkers for Immunotherapy in Lung Cancer: Perspective From the International Association for the Study of Lung Cancer Pathology Committee by Mino-Kenudson, Mari, Schalper, Kurt, Cooper, Wendy, Dacic, Sanja, Hirsch, Fred R, Jain, Deepali, Lopez-Rios, Fernando, Tsao, Ming Sound, Yatabe, Yasushi, Beasley, Mary Beth, Yu, Hui, Sholl, Lynette M, Brambilla, Elizabeth, Chou, Teh-Ying, Connolly, Casey, Wistuba, Ignacio, Kerr, Keith M, Lantuejoul, Sylvie

“…Immunotherapy including immune checkpoint inhibitors (ICIs) has become the backbone of treatment for most lung cancers with advanced or metastatic disease. In…”
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Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma by Shanmugam, Vignesh, Griffin, Gabriel K., Jacobsen, Eric D., Fletcher, Christopher D. M., Sholl, Lynette M., Hornick, Jason L.

“…Recent studies have demonstrated recurrent activating mutations involving the classical MAPK and PI3K signaling pathways in a large proportion of histiocytic…”
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Targeted Genomic Profiling Reveals Recurrent KRAS Mutations in Mesonephric-like Adenocarcinomas of the Female Genital Tract by Mirkovic, Jelena, McFarland, Marie, Garcia, Elizabeth, Sholl, Lynette M, Lindeman, Neal, MacConaill, Laura, Dong, Fei, Hirsch, Michelle, Nucci, Marisa R, Quick, Charles M, Crum, Christopher P, McCluggage, W Glenn, Howitt, Brooke E

“…Mesonephric adenocarcinoma most commonly arises in the cervix and is presumed to be derived from normal or hyperplastic mesonephric remnants. It is…”
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