Search Results - "Shokat, K.M"

Chemically targeting the PI3K family by Knight, Z A, Shokat, K M

“…PI3K (phosphoinositide 3-kinase) is a key regulator of cell growth, metabolism and survival. The frequent activation of the PI3K pathway in cancer has…”
Get more information

73 Differential pathway resiliency in response to MAPK inhibition in BRAF-mutant cancer by Sos, M, Levin, R.S, Gordan, J.D, Oses-Prieto, J.A, Webber, J.T, Salt, M, Hann, B, Burlingame, A.L, McCormick, F, Bandyopadhyay, S, Shokat, K.M

Get full text

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors by Ducker, G S, Atreya, C E, Simko, J P, Hom, Y K, Matli, M R, Benes, C H, Hann, B, Nakakura, E K, Bergsland, E K, Donner, D B, Settleman, J, Shokat, K M, Warren, R S

“…The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But…”
Get full text

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML by Park, S, Chapuis, N, Bardet, V, Tamburini, J, Gallay, N, Willems, L, Knight, Z A, Shokat, K M, Azar, N, Viguié, F, Ifrah, N, Dreyfus, F, Mayeux, P, Lacombe, C, Bouscary, D

“…The phosphatidylinositol 3-kinase (PI3K)/Akt and mammalian target of rapamycin complex 1 (mTORC1) signaling pathways are frequently activated in acute…”
Get full text

Bio-orthogonal Affinity Purification of Direct Kinase Substrates by Allen, Jasmina J, Lazerwith, Scott E, Shokat, Kevan M

“…Protein phosphorylation is a major mechanism of post-translational protein modification used to control cellular signaling. A challenge in phosphoproteomics is…”
Get full text

A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src by Liu, Y., Shah, K., Yang, F., Witucki, L., Shokat, K.M.

“…Engineered proteins with specificity for unnatural substrates or ligands are useful tools for studying or manipulating complex biological systems. We have…”
Get full text

Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor by Kung, C, Kenski, D.M, Dickerson, S.H, Howson, R.W, Kuyper, L.F, Madhani, H.D, Shokat, K.M

“…The identification of the kinase or kinases targeted by protein kinase inhibitors is a critical challenge in validating their use as therapeutic agents or…”
Get full text

A new strategy for the generation of catalytic antibodies by Shokat, K. M, Leumann, C. J, Sugasawara, R, Schultz, P. G

“…The high binding affinity and specificity of antibodies for a wide range of ligands has recently been exploited in the generation of catalysts for…”
Get full text