Search Results - "Shoeb, Mohamed R."
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Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation
Published in Nature communications (27-02-2024)“…Neutrophils are evolutionarily conserved innate immune cells playing pivotal roles in host defense. Zebrafish models have contributed substantially to our…”
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Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity
Published in Science immunology (26-11-2021)“…Helios, a member of the Ikaros family of transcription factors, is predominantly expressed in developing thymocytes, activated T cells, and regulatory T cells…”
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Genotypic characterization of multiple drug resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt
Published in Scientific reports (05-03-2020)“…Infection with multiple drug resistant (MDR) Escherichia coli poses a life threat to immunocompromised pediatric cancer patients. Our aim is to genotypically…”
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Author Correction: Genotypic characterization of multiple drug resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt
Published in Scientific reports (29-04-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation
Published in Blood advances (12-04-2022)“…Helios, encoded by IKZF2, is a member of the Ikaros family of transcription factors with pivotal roles in T-follicular helper, NK- and T-regulatory cell…”
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A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations
Published in Nature communications (03-05-2024)“…Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs…”
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Abstract 3542: A stem cell model dissects detrimental effects of neuroblastoma-linked chromosomal aberrations on cell differentiation during neural crest development
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Early childhood malignancies are driven by sparse genetic aberrations in oncogenes that often co-occur with large copy number variants (CNVs). The combination…”
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