Search Results - "Shockley, Keith"

Quantitative high-throughput screening data analysis: challenges and recent advances by Shockley, Keith R.

“…•Quantitative HTS has much potential to advance drug discovery and toxicity testing.•Nonlinear modeling of concentration–response data in suboptimal designs is…”
Get full text

Estimating Potency in High-Throughput Screening Experiments by Maximizing the Rate of Change in Weighted Shannon Entropy by Shockley, Keith R.

“…High-throughput in vitro screening experiments can be used to generate concentration-response data for large chemical libraries. It is often desirable to…”
Get full text

Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes by Pei, Ying, Peng, Jun, Behl, Mamta, Sipes, Nisha S, Shockley, Keith R, Rao, Mahendra S, Tice, Raymond R, Zeng, Xianmin

“…Abstract Induced pluripotent stem cells (iPSC) and their differentiated derivatives offer a unique source of human primary cells for toxicity screens. Here, we…”
Get full text

Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues by Anafi, Ron C, Pellegrino, Renata, Shockley, Keith R, Romer, Micah, Tufik, Sergio, Pack, Allan I

“…Many have assumed that the primary function of sleep is for the brain. We evaluated the molecular consequences of sleep and sleep deprivation outside the…”
Get full text

Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats by Witchey, Shannah K, Sutherland, Vicki, Collins, Brad, Roberts, Georgia, Shockley, Keith R, Vallant, Molly, Krause, Jeffrey, Cunny, Helen, Waidyanatha, Suramya, Mylchreest, Eve, Sparrow, Barney, Moyer, Robert, Behl, Mamta

“…Two organophosphate esters used as flame retardants and plasticizers, triphenyl phosphate (TPHP) and isopropylated phenyl phosphate (IPP), have been detected…”
Get full text

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway by Huang, Ruili, Sakamuru, Srilatha, Martin, Matt T., Reif, David M., Judson, Richard S., Houck, Keith A., Casey, Warren, Hsieh, Jui-Hua, Shockley, Keith R., Ceger, Patricia, Fostel, Jennifer, Witt, Kristine L., Tong, Weida, Rotroff, Daniel M., Zhao, Tongan, Shinn, Paul, Simeonov, Anton, Dix, David J., Austin, Christopher P., Kavlock, Robert J., Tice, Raymond R., Xia, Menghang

“…The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor…”
Get full text

Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits by Boyd, Windy A, Smith, Marjolein V, Co, Caroll A, Pirone, Jason R, Rice, Julie R, Shockley, Keith R, Freedman, Jonathan H

“…Modern toxicology is shifting from an observational to a mechanistic science. As part of this shift, high-throughput toxicity assays are being developed using…”
Get full text

A Three-Stage Algorithm to Make Toxicologically Relevant Activity Calls from Quantitative High Throughput Screening Data by Shockley, Keith R.

“…Background: The ability of a substance to induce a toxicological response is better understood by analyzing the response profile over a broad range of…”
Get full text

Bisphenol A affects androgen receptor function via multiple mechanisms by Teng, Christina, Goodwin, Bonnie, Shockley, Keith, Xia, Menghang, Huang, Ruili, Norris, John, Merrick, B. Alex, Jetten, Anton M., Austin, Christopher P., Tice, Raymond R.

“…•BPA antagonizes AR function by competitive inhibition of androgen binding.•Prevents functional foci formation in the nucleus.•Reduce the AR presence in the…”
Get full text

Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure by Smith‐Roe, Stephanie L., Wyde, Michael E., Stout, Matthew D., Winters, John W., Hobbs, Cheryl A., Shepard, Kim G., Green, Amanda S., Kissling, Grace E., Shockley, Keith R., Tice, Raymond R., Bucher, John R., Witt, Kristine L.

“…The National Toxicology Program tested two common radiofrequency radiation (RFR) modulations emitted by cellular telephones in a 2‐year rodent cancer bioassay…”
Get full text

Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity by French, John E, Gatti, Daniel M, Morgan, Daniel L, Kissling, Grace E, Shockley, Keith R, Knudsen, Gabriel A, Shepard, Kim G, Price, Herman C, King, Deborah, Witt, Kristine L, Pedersen, Lars C, Munger, Steven C, Svenson, Karen L, Churchill, Gary A

“…Inhalation of benzene at levels below the current exposure limit values leads to hematotoxicity in occupationally exposed workers. We sought to evaluate…”
Get full text

Macromolecule biosynthesis: a key function of sleep by Mackiewicz, Miroslaw, Shockley, Keith R, Romer, Micah A, Galante, Raymond J, Zimmerman, John E, Naidoo, Nirinjini, Baldwin, Donald A, Jensen, Shane T, Churchill, Gary A, Pack, Allan I

“…1 Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 2 Division of Sleep…”
Get full text

Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat by Shockley, Keith R., Cora, Michelle C., Malarkey, David E., Jackson-Humbles, Daven, Vallant, Molly, Collins, Brad J., Mutlu, Esra, Robinson, Veronica G., Waidyanatha, Surayma, Zmarowski, Amy, Machesky, Nicholas, Richey, Jamie, Harbo, Sam, Cheng, Emily, Patton, Kristin, Sparrow, Barney, Dunnick, June K.

“…[Display omitted] •Toxicity of legacy and emerging brominated flame retardants.•5-Day Toxicogenomic studies.•Liver toxicity.•Benchmark dose analysis using…”
Get full text

Statistical Guidance for Reviewers of Toxicologic Pathology by Shockley, Keith R., Kissling, Grace E.

“…Study design, statistical analysis, interpretation of results, and conclusions should be a part of all research papers. Statistics are integral to each of…”
Get full text

Evaluation of immunotoxicity of sodium metavanadate following drinking water exposure in female B6C3F1/N mice in a 28-day study by Frawley, Rachel, Johnson, Victor J, Burleson, Gary R, Shockley, Keith R, Cesta, Mark F, Travlos, Greg, Cora, Michelle, Roberts, Georgia, Germolec, Dori

“…Sodium metavanadate (NaVO ) is a pentavalent vanadium compound used in the metal industry and dietary supplements; human exposure occurs through inhalation of…”
Get full text

Gene expression profiling after exposure to a chemical carcinogen, Pentabrominated Diphenyl Ether, at different life stages by Shockley, Keith R, Dunnick, June K

“…Exposure to environmental hazards occurs at different stages of our lifetime-infant, child, adult. This study integrates recently published toxicogenomics data…”
Get full text

Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: Isolating independent associations with diet/energy balance and body weight by Perron, Isaac J, Keenan, Brendan T, Chellappa, Karthikeyani, Lahens, Nicholas F, Yohn, Nicole L, Shockley, Keith R, Pack, Allan I, Veasey, Sigrid C

“…Associated with numerous metabolic and behavioral abnormalities, obesity is classified by metrics reliant on body weight (such as body mass index). However,…”
Get full text

Immunotoxicity of N-butylbenzenesulfonamide: impacts on immune function in adult mice and developmentally exposed rats by Johnson, Victor J, Rider, Cynthia V, Luster, Michael I, Brix, Amy, Burleson, Gary R, Cora, Michelle, Elmore, Susan A, Frawley, Rachel P, Lopez, Franklin R, Mutlu, Esra, Shockley, Keith R, Pierfelice, Jessica, Burback, Brian, Co, Caroll A, Germolec, Dori R

“…Abstract N-butylbenzenesulfonamide (NBBS) is a high-production volume plasticizer that is an emerging contaminant of concern for environmental and human…”
Get full text

Using Artificial Intelligence to Detect, Classify, and Objectively Score Severity of Rodent Cardiomyopathy by Tokarz, Debra A., Steinbach, Thomas J., Lokhande, Avinash, Srivastava, Gargi, Ugalmugle, Rajesh, Co, Caroll A., Shockley, Keith R., Singletary, Emily, Cesta, Mark F., Thomas, Heath C., Chen, Vivian S., Hobbie, Kristen, Crabbs, Torrie A.

“…Rodent progressive cardiomyopathy (PCM) encompasses a constellation of microscopic findings commonly seen as a spontaneous background change in rat and mouse…”
Get full text

Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library by Chen, Shiuan, Hsieh, Jui-Hua, Huang, Ruili, Sakamuru, Srilatha, Hsin, Li-Yu, Xia, Menghang, Shockley, Keith R, Auerbach, Scott, Kanaya, Noriko, Lu, Hannah, Svoboda, Daniel, Witt, Kristine L, Merrick, B Alex, Teng, Christina T, Tice, Raymond R

“…Multiple mechanisms exist for endocrine disruption; one nonreceptor-mediated mechanism is via effects on aromatase, an enzyme critical for maintaining the…”
Get full text