Search Results - "Shoblock, James R"

Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432 by Lord, Brian, Aluisio, Leah, Shoblock, James R, Neff, Robert A, Varlinskaya, Elena I, Ceusters, Marc, Lovenberg, Timothy W, Carruthers, Nicholas, Bonaventure, Pascal, Letavic, Michael A, Deak, Terrence, Drinkenburg, Wilhelmus, Bhattacharya, Anindya

“…In the central nervous system, the ATP-gated Purinergic receptor P2X ligand-gated ion channel 7 (P2X7) is expressed in glial cells and modulates…”
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Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement by Shoblock, James R., Welty, Natalie, Aluisio, Leah, Fraser, Ian, Motley, S. Timothy, Morton, Kirsten, Palmer, James, Bonaventure, Pascal, Carruthers, Nicholas I., Lovenberg, Timothy W., Boggs, Jamin, Galici, Ruggero

“…Rationale Orexin-1 receptor antagonists have been shown to block the reinforcing effects of drugs of abuse and food. However, whether blockade of orexin-2…”
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In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist by Shoblock, James R, Welty, Natalie, Fraser, Ian, Wyatt, Ryan, Lord, Brian, Lovenberg, Timothy, Liu, Changlu, Bonaventure, Pascal

“…Recently, our group along with another demonstrated that GPR139 can be activated by L-phenylalanine (L-Phe) and L-tryptophan (L-Trp) at physiologically…”
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JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats by Galici, Ruggero, Rezvani, Amir H., Aluisio, Leah, Lord, Brian, Levin, Edward D., Fraser, Ian, Boggs, Jamin, Welty, Natalie, Shoblock, James R., Motley, S. Timothy, Letavic, Michael A., Carruthers, Nicholas I., Dugovic, Christine, Lovenberg, Timothy W., Bonaventure, Pascal

“…Rationale A few recent studies suggest that brain histamine levels and signaling via H 3 receptors play an important role in modulation of alcohol stimulation…”
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The effects of thioperamide on extracellular levels of glutamate and GABA in the rat prefrontal cortex by Welty, Natalie, Shoblock, James R.

“…Rationale Histamine H3 receptors (H3R) are presynaptic heteroreceptors that negatively modulate the release of histamine and other neurotransmitters such as…”
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Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats by SHOBLOCK, James R, SULLIVAN, Eric B, MAISONNEUVE, Isabelle M, GLICK, Stanley D

“…Methamphetamine (METH) and amphetamine (AMPH) are both abused psychostimulants. Although METH is generally accepted to be more addictive and potent than its…”
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Constitutively Active Mu Opioid Receptors Mediate the Enhanced Conditioned Aversive Effect of Naloxone in Morphine-Dependent Mice by SHOBLOCK, James R, MAIDMENT, Nigel T

“…Naloxone administration produces a robust conditioned place aversion (CPA) in opiate-naive rodents by blocking the action of enkephalins at mu opioid…”
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Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567 by Bhattacharya, Anindya, Wang, Qi, Ao, Hong, Shoblock, James R, Lord, Brian, Aluisio, Leah, Fraser, Ian, Nepomuceno, Diane, Neff, Robert A, Welty, Natalie, Lovenberg, Timothy W, Bonaventure, Pascal, Wickenden, Alan D, Letavic, Michael A

“…Background and Purpose An increasing body of evidence suggests that the purinergic receptor P2X, ligand‐gated ion channel, 7 (P2X7) in the CNS may play a key…”
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In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor by Shoblock, James R., Welty, Natalie, Nepomuceno, Diane, Lord, Brian, Aluisio, Leah, Fraser, Ian, Motley, S. Timothy, Sutton, Steve W., Morton, Kirsten, Galici, Ruggero, Atack, John R., Dvorak, Lisa, Swanson, Devin M., Carruthers, Nicholas I., Dvorak, Curt, Lovenberg, Timothy W., Bonaventure, Pascal

“…Rationale The lack of potent, selective, brain penetrant Y 2 receptor antagonists has hampered in vivo functional studies of this receptor. Objective Here, we…”
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The effect of a systemically active ORL-1 agonist, Ro 64-6198, on the acquisition, expression, extinction, and reinstatement of morphine conditioned place preference by Shoblock, James R., Wichmann, Jürgen, Maidment, Nigel T.

“…ORL-1 agonists have been proposed as potential therapeutics for substance abuse based on their propensity to counter the effects of mu opioid agonists in…”
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Differences between d-methamphetamine and d-amphetamine in rats: working memory, tolerance, and extinction by SHOBLOCK, James R, MAISONNEUVE, Isabelle M, GLICK, Stanley D

“…Previously, we have shown that d-amphetamine (AMPH) was more potent than d-methamphetamine (METH) at increasing extracellular levels of dopamine (DA) in the…”
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Differential interactions of desipramine with amphetamine and methamphetamine: evidence that amphetamine releases dopamine from noradrenergic neurons in the medial prefrontal cortex by Shoblock, James R, Maisonneuve, Isabelle M, Glick, Stanley D

“…Amphetamine is more effective than methamphetamine at raising dopamine levels in the prefrontal cortex. The current study tested the hypothesis that…”
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The Pharmacology of Ro 64‐6198, a Systemically Active, Nonpeptide NOP Receptor (Opiate Receptor‐Like 1, ORL‐1) Agonist with Diverse Preclinical Therapeutic Activity by Shoblock, James R.

“…ABSTRACT The NOP receptor (formerly referred to as opiate receptor‐like 1, ORL‐1, LC132, OP4, or NOP1) is a G protein–coupled receptor that shares high…”
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PET Brain Imaging of Neuropeptide Y2 Receptors Using N-^sup 11^C-Methyl-JNJ-31020028 in Pigs by Winterdahl, Michael, Audrain, Hélène, Landau, Anne M, Smith, Donald F, Bonaventure, Pascal, Shoblock, James R, Carruthers, Nicholas, Swanson, Devin, Bender, Dirk

“…Neuropeptide Y2 (NPY2) receptors are implicated in diverse brain disorders, but no suitable PET radiotracers are currently available for studying NPY2…”
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PET Brain Imaging of Neuropeptide Y2 Receptors Using N - 11 C-Methyl-JNJ-31020028 in Pigs by Winterdahl, Michael, Audrain, Hélène, Landau, Anne M., Smith, Donald F., Bonaventure, Pascal, Shoblock, James R., Carruthers, Nicholas, Swanson, Devin, Bender, Dirk

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PET Brain Imaging of Neuropeptide Y2 Receptors Using N- sigma up 11 not equal to -Methyl-JNJ-31020028 in Pigs by Winterdahl, Michael, Audrain, Helene, Landau, Anne M, Smith, Donald F, Bonaventure, Pascal, Shoblock, James R, Carruthers, Nicholas, Swanson, Devin, Bender, Dirk

“…Neuropeptide Y2 (NPY2) receptors are implicated in diverse brain disorders, but no suitable PET radiotracers are currently available for studying NPY2…”
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Constitutively active micro opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice by Shoblock, James R, Maidment, Nigel T

“…Naloxone administration produces a robust conditioned place aversion (CPA) in opiate-naive rodents by blocking the action of enkephalins at mu opioid…”
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JNJ-39220675, a novel selective histamine [H.sub.3] receptor antagonist, reduces the abuse-related effects of alcohol in rats by Galici, Ruggero, Rezvani, Amir H, Aluisio, Leah, Lord, Brian, Levin, Edward D, Fraser, Ian, Boggs, Jamin, Welty, Natalie, Shoblock, James R, Motley, S. Timothy, Letavic, Michael A, Carruthers, Nicholas I, Dugovic, Christine, Lovenberg, Timothy W, Bonaventure, Pascal

“…Rationale A few recent studies suggest that brain histamine levels and signaling via [H.sub.3] receptors play an important role in modulation of alcohol…”
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JNJ-39220675, a novel selective histamine H sub(3) receptor antagonist, reduces the abuse-related effects of alcohol in rats by Galici, Ruggero, Rezvani, Amir H, Aluisio, Leah, Lord, Brian, Levin, Edward D, Fraser, Ian, Boggs, Jamin, Welty, Natalie, Shoblock, James R, Motley, STimothy, Letavic, Michael A, Carruthers, Nicholas I, Dugovic, Christine, Lovenberg, Timothy W, Bonaventure, Pascal

“…Rationale: A few recent studies suggest that brain histamine levels and signaling via H sub(3) receptors play an important role in modulation of alcohol…”
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JNJ-39220675, a novel selective histamine H^sub 3^ receptor antagonist, reduces the abuse-related effects of alcohol in rats by Galici, Ruggero, Rezvani, Amir H, Aluisio, Leah, Lord, Brian, Levin, Edward D, Fraser, Ian, Boggs, Jamin, Welty, Natalie, Shoblock, James R, Motley, S Timothy, Letavic, Michael A, Carruthers, Nicholas I, Dugovic, Christine, Lovenberg, Timothy W, Bonaventure, Pascal

“…A few recent studies suggest that brain histamine levels and signaling via H^sub 3^ receptors play an important role in modulation of alcohol stimulation and…”
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